Role of Oxytocin and Vasopressin in Neuropsychiatric Disorders: Therapeutic Potential of Agonists and Antagonists

Oxytocin (OT) and vasopressin (AVP) are hypothalamic neuropeptides classically associated with their regulatory role in reproduction, water homeostasis, and social behaviors. Interestingly, this role has expanded in recent years and has positioned these neuropeptides as therapeutic targets for vario...

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Autores principales:	Valeska Cid-Jofré, Macarena Moreno, Miguel Reyes-Parada, Georgina M. Renard
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	neuropeptides oxytocin vasopressin pharmacology antagonists agonists Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/ee95e86c18c64c92a92ba166ea994673
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spelling	oai:doaj.org-article:ee95e86c18c64c92a92ba166ea9946732021-11-11T17:27:55ZRole of Oxytocin and Vasopressin in Neuropsychiatric Disorders: Therapeutic Potential of Agonists and Antagonists10.3390/ijms2221120771422-00671661-6596https://doaj.org/article/ee95e86c18c64c92a92ba166ea9946732021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/12077https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Oxytocin (OT) and vasopressin (AVP) are hypothalamic neuropeptides classically associated with their regulatory role in reproduction, water homeostasis, and social behaviors. Interestingly, this role has expanded in recent years and has positioned these neuropeptides as therapeutic targets for various neuropsychiatric diseases such as autism, addiction, schizophrenia, depression, and anxiety disorders. Due to the chemical-physical characteristics of these neuropeptides including short half-life, poor blood-brain barrier penetration, promiscuity for AVP and OT receptors (AVP-R, OT-R), novel ligands have been developed in recent decades. This review summarizes the role of OT and AVP in neuropsychiatric conditions, as well as the findings of different OT-R and AVP-R agonists and antagonists, used both at the preclinical and clinical level. Furthermore, we discuss their possible therapeutic potential for central nervous system (CNS) disorders.Valeska Cid-JofréMacarena MorenoMiguel Reyes-ParadaGeorgina M. RenardMDPI AGarticleneuropeptidesoxytocinvasopressinpharmacologyantagonistsagonistsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12077, p 12077 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neuropeptides oxytocin vasopressin pharmacology antagonists agonists Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	neuropeptides oxytocin vasopressin pharmacology antagonists agonists Biology (General) QH301-705.5 Chemistry QD1-999 Valeska Cid-Jofré Macarena Moreno Miguel Reyes-Parada Georgina M. Renard Role of Oxytocin and Vasopressin in Neuropsychiatric Disorders: Therapeutic Potential of Agonists and Antagonists
description	Oxytocin (OT) and vasopressin (AVP) are hypothalamic neuropeptides classically associated with their regulatory role in reproduction, water homeostasis, and social behaviors. Interestingly, this role has expanded in recent years and has positioned these neuropeptides as therapeutic targets for various neuropsychiatric diseases such as autism, addiction, schizophrenia, depression, and anxiety disorders. Due to the chemical-physical characteristics of these neuropeptides including short half-life, poor blood-brain barrier penetration, promiscuity for AVP and OT receptors (AVP-R, OT-R), novel ligands have been developed in recent decades. This review summarizes the role of OT and AVP in neuropsychiatric conditions, as well as the findings of different OT-R and AVP-R agonists and antagonists, used both at the preclinical and clinical level. Furthermore, we discuss their possible therapeutic potential for central nervous system (CNS) disorders.
format	article
author	Valeska Cid-Jofré Macarena Moreno Miguel Reyes-Parada Georgina M. Renard
author_facet	Valeska Cid-Jofré Macarena Moreno Miguel Reyes-Parada Georgina M. Renard
author_sort	Valeska Cid-Jofré
title	Role of Oxytocin and Vasopressin in Neuropsychiatric Disorders: Therapeutic Potential of Agonists and Antagonists
title_short	Role of Oxytocin and Vasopressin in Neuropsychiatric Disorders: Therapeutic Potential of Agonists and Antagonists
title_full	Role of Oxytocin and Vasopressin in Neuropsychiatric Disorders: Therapeutic Potential of Agonists and Antagonists
title_fullStr	Role of Oxytocin and Vasopressin in Neuropsychiatric Disorders: Therapeutic Potential of Agonists and Antagonists
title_full_unstemmed	Role of Oxytocin and Vasopressin in Neuropsychiatric Disorders: Therapeutic Potential of Agonists and Antagonists
title_sort	role of oxytocin and vasopressin in neuropsychiatric disorders: therapeutic potential of agonists and antagonists
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ee95e86c18c64c92a92ba166ea994673
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Role of Oxytocin and Vasopressin in Neuropsychiatric Disorders: Therapeutic Potential of Agonists and Antagonists

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