Pathophysiology of Cholestatic Liver Diseases: New Insights into the Mechanisms of Bile Infarct Formation

Cholestatic liver diseases can be induced for many reasons including obstructions, e.g. by stones or tumors. An early consequence of obstructive cholestasis is the formation of bile infarcts, which refer to clusters of dead hepatocytes due to bile salt accumulation. Although these infarcts were desc...

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Autores principales:	Reham Hassan, Abdel-latif Seddek, hmed Ghallab
Formato:	article
Lenguaje:	EN
Publicado:	South Valley University 2018
Materias:	Cholestasis intravital imaging bile canaliculi bile salt toxicity bile leakage bile duct ligation. Agriculture S Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/ee9c5c56d04746e386499522c7397023
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spelling	oai:doaj.org-article:ee9c5c56d04746e386499522c73970232021-12-02T09:54:34ZPathophysiology of Cholestatic Liver Diseases: New Insights into the Mechanisms of Bile Infarct Formation10.21608/svu.2018.221622535-18262535-1877https://doaj.org/article/ee9c5c56d04746e386499522c73970232018-12-01T00:00:00Zhttps://svu.journals.ekb.eg/article_22162.htmlhttps://doaj.org/toc/2535-1826https://doaj.org/toc/2535-1877Cholestatic liver diseases can be induced for many reasons including obstructions, e.g. by stones or tumors. An early consequence of obstructive cholestasis is the formation of bile infarcts, which refer to clusters of dead hepatocytes due to bile salt accumulation. Although these infarcts were described long time ago (in 1876 by Charcot and Gombault), the leading mechanism is still unclear. Some hypotheses suggested direct killing by accumulation of bile salts up to toxic levels. Others claim indirect cell death via immune cell infiltration and inflammatory cytokine release. However, the sequence of events leading to the formation bile infarcts are still unclear. In the recent issue of Hepatology, Ghallab and his colleagues have recorded in a time-resolved manner the key events leading to bile infarct formation and the subsequent systemic changes, using two-photon based intravital imaging. This mini-review highlights the results of this study and discuss the time-resolved events in acute and chronic cholestasis, as well as the link between biliary bile salts and hepatocyte death. Reham HassanAbdel-latif Seddekhmed GhallabSouth Valley UniversityarticleCholestasisintravital imagingbile canaliculibile salt toxicitybile leakagebile duct ligation.AgricultureSVeterinary medicineSF600-1100ENSVU-International Journal of Veterinary Sciences, Vol 1, Iss 2, Pp 95-105 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cholestasis intravital imaging bile canaliculi bile salt toxicity bile leakage bile duct ligation. Agriculture S Veterinary medicine SF600-1100
spellingShingle	Cholestasis intravital imaging bile canaliculi bile salt toxicity bile leakage bile duct ligation. Agriculture S Veterinary medicine SF600-1100 Reham Hassan Abdel-latif Seddek hmed Ghallab Pathophysiology of Cholestatic Liver Diseases: New Insights into the Mechanisms of Bile Infarct Formation
description	Cholestatic liver diseases can be induced for many reasons including obstructions, e.g. by stones or tumors. An early consequence of obstructive cholestasis is the formation of bile infarcts, which refer to clusters of dead hepatocytes due to bile salt accumulation. Although these infarcts were described long time ago (in 1876 by Charcot and Gombault), the leading mechanism is still unclear. Some hypotheses suggested direct killing by accumulation of bile salts up to toxic levels. Others claim indirect cell death via immune cell infiltration and inflammatory cytokine release. However, the sequence of events leading to the formation bile infarcts are still unclear. In the recent issue of Hepatology, Ghallab and his colleagues have recorded in a time-resolved manner the key events leading to bile infarct formation and the subsequent systemic changes, using two-photon based intravital imaging. This mini-review highlights the results of this study and discuss the time-resolved events in acute and chronic cholestasis, as well as the link between biliary bile salts and hepatocyte death.
format	article
author	Reham Hassan Abdel-latif Seddek hmed Ghallab
author_facet	Reham Hassan Abdel-latif Seddek hmed Ghallab
author_sort	Reham Hassan
title	Pathophysiology of Cholestatic Liver Diseases: New Insights into the Mechanisms of Bile Infarct Formation
title_short	Pathophysiology of Cholestatic Liver Diseases: New Insights into the Mechanisms of Bile Infarct Formation
title_full	Pathophysiology of Cholestatic Liver Diseases: New Insights into the Mechanisms of Bile Infarct Formation
title_fullStr	Pathophysiology of Cholestatic Liver Diseases: New Insights into the Mechanisms of Bile Infarct Formation
title_full_unstemmed	Pathophysiology of Cholestatic Liver Diseases: New Insights into the Mechanisms of Bile Infarct Formation
title_sort	pathophysiology of cholestatic liver diseases: new insights into the mechanisms of bile infarct formation
publisher	South Valley University
publishDate	2018
url	https://doaj.org/article/ee9c5c56d04746e386499522c7397023
work_keys_str_mv	AT rehamhassan pathophysiologyofcholestaticliverdiseasesnewinsightsintothemechanismsofbileinfarctformation AT abdellatifseddek pathophysiologyofcholestaticliverdiseasesnewinsightsintothemechanismsofbileinfarctformation AT hmedghallab pathophysiologyofcholestaticliverdiseasesnewinsightsintothemechanismsofbileinfarctformation
_version_	1718397981261037568

Pathophysiology of Cholestatic Liver Diseases: New Insights into the Mechanisms of Bile Infarct Formation

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