A large population histology study showing the lack of association between ALT elevation and significant fibrosis in chronic hepatitis B.
<h4>Objective</h4>We determined the association between various clinical parameters and significant liver injury in both hepatitis B e antigen (HBeAg)-positive and HBeAg-negative patients.<h4>Methods</h4>From 1994 to 2008, liver biopsy was performed on 319 treatment-naïve CHB...
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2012
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oai:doaj.org-article:ee9d6451422b4cd2b7463c57663925ce2021-11-18T07:26:31ZA large population histology study showing the lack of association between ALT elevation and significant fibrosis in chronic hepatitis B.1932-620310.1371/journal.pone.0032622https://doaj.org/article/ee9d6451422b4cd2b7463c57663925ce2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22389715/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>We determined the association between various clinical parameters and significant liver injury in both hepatitis B e antigen (HBeAg)-positive and HBeAg-negative patients.<h4>Methods</h4>From 1994 to 2008, liver biopsy was performed on 319 treatment-naïve CHB patients. Histologic assessment was based on the Knodell histologic activity index for necroinflammation and the Ishak fibrosis staging for fibrosis.<h4>Results</h4>211 HBeAg-positive and 108 HBeAg-negative patients were recruited, with a median age of 31 and 46 years respectively. 9 out of 40 (22.5%) HBeAg-positive patients with normal ALT had significant histologic abnormalities (necroinflammation grading ≥ 7 or fibrosis score ≥ 3). There was a significant difference in fibrosis scores among HBeAg-positive patients with an ALT level within the Prati criteria (30 U/L for men, 19 U/L for women) and patients with a normal ALT but exceeding the Prati criteria (p = 0.024). Age, aspartate aminotransferase and platelet count were independent predictors of significant fibrosis in HBeAg-positive patients with an elevated ALT by multivariate analysis (p = 0.007, 0.047 and 0.045 respectively). HBV DNA and platelet count were predictors of significant fibrosis in HBeAg-negative disease (p = 0.020 and 0.015 respectively). An elevated ALT was not predictive of significant fibrosis for HBeAg-positive (p = 0.345) and -negative (p = 0.544) disease. There was no significant difference in fibrosis staging among ALT 1-2 × upper limit of normal (ULN) and > × 2 ULN for both HBeAg-positive (p = 0.098) and -negative (p = 0.838) disease.<h4>Conclusion</h4>An elevated ALT does not accurately predict significant liver injury. Decisions on commencing antiviral therapy should not be heavily based on a particular ALT threshold.Wai-Kay SetoChing-Lung LaiPhilip P C IpJames FungDanny Ka-Ho WongJohn Chi-Hang YuenIvan Fan-Ngai HungMan-Fung YuenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 2, p e32622 (2012) |
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Medicine R Science Q Wai-Kay Seto Ching-Lung Lai Philip P C Ip James Fung Danny Ka-Ho Wong John Chi-Hang Yuen Ivan Fan-Ngai Hung Man-Fung Yuen A large population histology study showing the lack of association between ALT elevation and significant fibrosis in chronic hepatitis B. |
| description |
<h4>Objective</h4>We determined the association between various clinical parameters and significant liver injury in both hepatitis B e antigen (HBeAg)-positive and HBeAg-negative patients.<h4>Methods</h4>From 1994 to 2008, liver biopsy was performed on 319 treatment-naïve CHB patients. Histologic assessment was based on the Knodell histologic activity index for necroinflammation and the Ishak fibrosis staging for fibrosis.<h4>Results</h4>211 HBeAg-positive and 108 HBeAg-negative patients were recruited, with a median age of 31 and 46 years respectively. 9 out of 40 (22.5%) HBeAg-positive patients with normal ALT had significant histologic abnormalities (necroinflammation grading ≥ 7 or fibrosis score ≥ 3). There was a significant difference in fibrosis scores among HBeAg-positive patients with an ALT level within the Prati criteria (30 U/L for men, 19 U/L for women) and patients with a normal ALT but exceeding the Prati criteria (p = 0.024). Age, aspartate aminotransferase and platelet count were independent predictors of significant fibrosis in HBeAg-positive patients with an elevated ALT by multivariate analysis (p = 0.007, 0.047 and 0.045 respectively). HBV DNA and platelet count were predictors of significant fibrosis in HBeAg-negative disease (p = 0.020 and 0.015 respectively). An elevated ALT was not predictive of significant fibrosis for HBeAg-positive (p = 0.345) and -negative (p = 0.544) disease. There was no significant difference in fibrosis staging among ALT 1-2 × upper limit of normal (ULN) and > × 2 ULN for both HBeAg-positive (p = 0.098) and -negative (p = 0.838) disease.<h4>Conclusion</h4>An elevated ALT does not accurately predict significant liver injury. Decisions on commencing antiviral therapy should not be heavily based on a particular ALT threshold. |
| format |
article |
| author |
Wai-Kay Seto Ching-Lung Lai Philip P C Ip James Fung Danny Ka-Ho Wong John Chi-Hang Yuen Ivan Fan-Ngai Hung Man-Fung Yuen |
| author_facet |
Wai-Kay Seto Ching-Lung Lai Philip P C Ip James Fung Danny Ka-Ho Wong John Chi-Hang Yuen Ivan Fan-Ngai Hung Man-Fung Yuen |
| author_sort |
Wai-Kay Seto |
| title |
A large population histology study showing the lack of association between ALT elevation and significant fibrosis in chronic hepatitis B. |
| title_short |
A large population histology study showing the lack of association between ALT elevation and significant fibrosis in chronic hepatitis B. |
| title_full |
A large population histology study showing the lack of association between ALT elevation and significant fibrosis in chronic hepatitis B. |
| title_fullStr |
A large population histology study showing the lack of association between ALT elevation and significant fibrosis in chronic hepatitis B. |
| title_full_unstemmed |
A large population histology study showing the lack of association between ALT elevation and significant fibrosis in chronic hepatitis B. |
| title_sort |
large population histology study showing the lack of association between alt elevation and significant fibrosis in chronic hepatitis b. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/ee9d6451422b4cd2b7463c57663925ce |
| work_keys_str_mv |
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