Increased Serum Cystatin C Levels Were Associated with Depressive Symptoms in Patients with Type 2 Diabetes

Yue Huang,1,* Wenxun Huang,2,* Jing Wei,3 Zubin Yin,1 Hanjing Liu4 1Department of Psychosomatic Medicine, Chongqing University Three Gorges Hospital, Chongqing, 404000, People’s Republic of China; 2Department of Infectious Disease, Chongqing University Three Gorges Hospital, Chongqing, 404...

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Autores principales:	Huang Y, Huang W, Wei J, Yin Z, Liu H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	cystatin c dm depressive symptoms prognostic value Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/eea7a1dd354f4d91b4f4d9f0ae161d1f
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spelling	oai:doaj.org-article:eea7a1dd354f4d91b4f4d9f0ae161d1f2021-12-02T16:22:18ZIncreased Serum Cystatin C Levels Were Associated with Depressive Symptoms in Patients with Type 2 Diabetes1178-7007https://doaj.org/article/eea7a1dd354f4d91b4f4d9f0ae161d1f2021-02-01T00:00:00Zhttps://www.dovepress.com/increased-serum-cystatin-c-levels-were-associated-with-depressive-symp-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Yue Huang,1,* Wenxun Huang,2,* Jing Wei,3 Zubin Yin,1 Hanjing Liu4 1Department of Psychosomatic Medicine, Chongqing University Three Gorges Hospital, Chongqing, 404000, People’s Republic of China; 2Department of Infectious Disease, Chongqing University Three Gorges Hospital, Chongqing, 404000, People’s Republic of China; 3Department of Endocrinology, Chongqing Municipality Wanzhou District People’s Hospital, Chongqing, 404000, People’s Republic of China; 4Department of Clinical Psychology, The Chinese People’s Armed Police Force Zhejiang Corps Hospital, Hangzhou, 310051, Zhejiang Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hanjing LiuDepartment of Clinical Psychology, The Chinese People’s Armed Police Force Zhejiang Corps Hospital, No. 86, Jiangnan Avenue, Hangzhou, 310051, Zhejiang Province, People’s Republic of ChinaTel +86 13874451742Email liuhanjing666@126.comBackground: Existing studies have reported that patients with diabetes mellitus (DM) have an increased risk of depressive symptoms. We aimed to evaluate the association between serum cystatin C levels and depressive symptoms in DM patients.Methods: Serum levels of cystatin C were measured in 254 patients with DM at baseline. Cox proportional hazard analysis was used to evaluate the value of serum cystatin C in predicting depressive symptoms in patients with DM.Results: Multivariate linear regression analysis showed that serum cystatin C levels were independently associated with Centre for Epidemiological Studies Depression (CES-D) scores after adjusting for age, sex, body mass index (BMI), current smoking status, current drinking, admission systolic and diastolic blood pressure (BP), cardiovascular disease (CVD) history and laboratory measurements in patients with DM at baseline (Sβ= − 0.127; 95% CI, - 0.185– - 0.083; P=0.002). The multivariate Cox proportional hazard analysis revealed that serum cystatin C (HR=2.360, 95% CI 1.500– 3.891, P-trend < 0.001) was an independent prognostic factor for cognitive decline in these patients with DM during the follow-up period.Conclusion: Our results showed that increased serum cystatin C levels were significantly and independently associated with depressive symptoms and had independent predictive value for depressive symptoms in patients with DM. Serum cystatin C might enable early recognition of depressive symptoms among DM patients.Keywords: cystatin C, DM, depressive symptoms, prognostic valueHuang YHuang WWei JYin ZLiu HDove Medical Pressarticlecystatin cdmdepressive symptomsprognostic valueSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 857-863 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cystatin c dm depressive symptoms prognostic value Specialties of internal medicine RC581-951
spellingShingle	cystatin c dm depressive symptoms prognostic value Specialties of internal medicine RC581-951 Huang Y Huang W Wei J Yin Z Liu H Increased Serum Cystatin C Levels Were Associated with Depressive Symptoms in Patients with Type 2 Diabetes
description	Yue Huang,1,* Wenxun Huang,2,* Jing Wei,3 Zubin Yin,1 Hanjing Liu4 1Department of Psychosomatic Medicine, Chongqing University Three Gorges Hospital, Chongqing, 404000, People’s Republic of China; 2Department of Infectious Disease, Chongqing University Three Gorges Hospital, Chongqing, 404000, People’s Republic of China; 3Department of Endocrinology, Chongqing Municipality Wanzhou District People’s Hospital, Chongqing, 404000, People’s Republic of China; 4Department of Clinical Psychology, The Chinese People’s Armed Police Force Zhejiang Corps Hospital, Hangzhou, 310051, Zhejiang Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hanjing LiuDepartment of Clinical Psychology, The Chinese People’s Armed Police Force Zhejiang Corps Hospital, No. 86, Jiangnan Avenue, Hangzhou, 310051, Zhejiang Province, People’s Republic of ChinaTel +86 13874451742Email liuhanjing666@126.comBackground: Existing studies have reported that patients with diabetes mellitus (DM) have an increased risk of depressive symptoms. We aimed to evaluate the association between serum cystatin C levels and depressive symptoms in DM patients.Methods: Serum levels of cystatin C were measured in 254 patients with DM at baseline. Cox proportional hazard analysis was used to evaluate the value of serum cystatin C in predicting depressive symptoms in patients with DM.Results: Multivariate linear regression analysis showed that serum cystatin C levels were independently associated with Centre for Epidemiological Studies Depression (CES-D) scores after adjusting for age, sex, body mass index (BMI), current smoking status, current drinking, admission systolic and diastolic blood pressure (BP), cardiovascular disease (CVD) history and laboratory measurements in patients with DM at baseline (Sβ= − 0.127; 95% CI, - 0.185– - 0.083; P=0.002). The multivariate Cox proportional hazard analysis revealed that serum cystatin C (HR=2.360, 95% CI 1.500– 3.891, P-trend < 0.001) was an independent prognostic factor for cognitive decline in these patients with DM during the follow-up period.Conclusion: Our results showed that increased serum cystatin C levels were significantly and independently associated with depressive symptoms and had independent predictive value for depressive symptoms in patients with DM. Serum cystatin C might enable early recognition of depressive symptoms among DM patients.Keywords: cystatin C, DM, depressive symptoms, prognostic value
format	article
author	Huang Y Huang W Wei J Yin Z Liu H
author_facet	Huang Y Huang W Wei J Yin Z Liu H
author_sort	Huang Y
title	Increased Serum Cystatin C Levels Were Associated with Depressive Symptoms in Patients with Type 2 Diabetes
title_short	Increased Serum Cystatin C Levels Were Associated with Depressive Symptoms in Patients with Type 2 Diabetes
title_full	Increased Serum Cystatin C Levels Were Associated with Depressive Symptoms in Patients with Type 2 Diabetes
title_fullStr	Increased Serum Cystatin C Levels Were Associated with Depressive Symptoms in Patients with Type 2 Diabetes
title_full_unstemmed	Increased Serum Cystatin C Levels Were Associated with Depressive Symptoms in Patients with Type 2 Diabetes
title_sort	increased serum cystatin c levels were associated with depressive symptoms in patients with type 2 diabetes
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/eea7a1dd354f4d91b4f4d9f0ae161d1f
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_version_	1718384206603616256

Increased Serum Cystatin C Levels Were Associated with Depressive Symptoms in Patients with Type 2 Diabetes

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