Conjugation Of EGCG And Chitosan NPs As A Novel Nano-Drug Delivery System

Abdel-Majeed Safer,1 Stefano Leporatti,2 Jacquilion Jose,3 Mahmoud S Soliman4 1Department of Biological Sciences, Faculty of Science, Kuwait University, Kuwait City, Kuwait; 2CNR Nanotec, Istituto di Nanotecnologia, Lecce 73100, Italy; 3Nanoscopy Science Center, Faculty of Science, Kuwait University...

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Autores principales:	Safer AM, Leporatti S, Jose J, Soliman MS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Chitosan EGCG Conjugation Nano Drug Delivery Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/eea7ae0db65c4ffcbab365357521e9bf
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spelling	oai:doaj.org-article:eea7ae0db65c4ffcbab365357521e9bf2021-12-02T09:22:47ZConjugation Of EGCG And Chitosan NPs As A Novel Nano-Drug Delivery System1178-2013https://doaj.org/article/eea7ae0db65c4ffcbab365357521e9bf2019-10-01T00:00:00Zhttps://www.dovepress.com/conjugation-of-egcg-and-chitosan-nps-as-a-novel-nano-drug-delivery-sys-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Abdel-Majeed Safer,1 Stefano Leporatti,2 Jacquilion Jose,3 Mahmoud S Soliman4 1Department of Biological Sciences, Faculty of Science, Kuwait University, Kuwait City, Kuwait; 2CNR Nanotec, Istituto di Nanotecnologia, Lecce 73100, Italy; 3Nanoscopy Science Center, Faculty of Science, Kuwait University, Kuwait City, Kuwait; 4Nanotechnology Research Facility, Faculty of Engineering and Petroleum, College of Engineering and Petroleum, Kuwait University, Kuwait City, KuwaitCorrespondence: Abdel-Majeed SaferDepartment of Biological Sciences, Faculty of Science, Kuwait University, Kuwait City, KuwaitTel +965 2 498 5909Email saferam52@gmail.com Stefano LeporattiCNR Nanotec, Istituto di Nanotecnologia, Lecce, ItalyTel +39 0832 319 829Email stefano.leporatti@nanotec.cnr.itPurpose: Chitosan nanoparticles (CS NPs) have been used as a good vehicle for nano-drug delivery due to their good physicochemical properties. Epigallocatechin-3-gallate (EGCG), one of the major active ingredients of green tea, is a natural antioxidant that helps in reducing and preventing cell damage and fighting cancer, plus providing other benefits. The aim of this study is to optimise the preparation parameters in terms of the physical characteristics and stability in CS/EGCG NPs conjugation.Results: The conjugation of CS/EGCGNPs was obtained by means of Poloxamer 188. The average CS/EGCG NPs complex was of size 117.8±38.71nm with a surface charge of +67.8±4.38mV and isoelectric point at pH 7.61.Conclusion: In conclusion, NPs produced were stable at 4°C with nanometric size, good polydispersity, good loading and efficiency, envisaging to be a possible candidate for nano-therapeutic delivery system against hepatic fibrosis.Keywords: chitosan, EGCG, conjugation, nano-drug deliverySafer AMLeporatti SJose JSoliman MSDove Medical PressarticleChitosanEGCGConjugationNano Drug DeliveryMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 8033-8046 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chitosan EGCG Conjugation Nano Drug Delivery Medicine (General) R5-920
spellingShingle	Chitosan EGCG Conjugation Nano Drug Delivery Medicine (General) R5-920 Safer AM Leporatti S Jose J Soliman MS Conjugation Of EGCG And Chitosan NPs As A Novel Nano-Drug Delivery System
description	Abdel-Majeed Safer,1 Stefano Leporatti,2 Jacquilion Jose,3 Mahmoud S Soliman4 1Department of Biological Sciences, Faculty of Science, Kuwait University, Kuwait City, Kuwait; 2CNR Nanotec, Istituto di Nanotecnologia, Lecce 73100, Italy; 3Nanoscopy Science Center, Faculty of Science, Kuwait University, Kuwait City, Kuwait; 4Nanotechnology Research Facility, Faculty of Engineering and Petroleum, College of Engineering and Petroleum, Kuwait University, Kuwait City, KuwaitCorrespondence: Abdel-Majeed SaferDepartment of Biological Sciences, Faculty of Science, Kuwait University, Kuwait City, KuwaitTel +965 2 498 5909Email saferam52@gmail.com Stefano LeporattiCNR Nanotec, Istituto di Nanotecnologia, Lecce, ItalyTel +39 0832 319 829Email stefano.leporatti@nanotec.cnr.itPurpose: Chitosan nanoparticles (CS NPs) have been used as a good vehicle for nano-drug delivery due to their good physicochemical properties. Epigallocatechin-3-gallate (EGCG), one of the major active ingredients of green tea, is a natural antioxidant that helps in reducing and preventing cell damage and fighting cancer, plus providing other benefits. The aim of this study is to optimise the preparation parameters in terms of the physical characteristics and stability in CS/EGCG NPs conjugation.Results: The conjugation of CS/EGCGNPs was obtained by means of Poloxamer 188. The average CS/EGCG NPs complex was of size 117.8±38.71nm with a surface charge of +67.8±4.38mV and isoelectric point at pH 7.61.Conclusion: In conclusion, NPs produced were stable at 4°C with nanometric size, good polydispersity, good loading and efficiency, envisaging to be a possible candidate for nano-therapeutic delivery system against hepatic fibrosis.Keywords: chitosan, EGCG, conjugation, nano-drug delivery
format	article
author	Safer AM Leporatti S Jose J Soliman MS
author_facet	Safer AM Leporatti S Jose J Soliman MS
author_sort	Safer AM
title	Conjugation Of EGCG And Chitosan NPs As A Novel Nano-Drug Delivery System
title_short	Conjugation Of EGCG And Chitosan NPs As A Novel Nano-Drug Delivery System
title_full	Conjugation Of EGCG And Chitosan NPs As A Novel Nano-Drug Delivery System
title_fullStr	Conjugation Of EGCG And Chitosan NPs As A Novel Nano-Drug Delivery System
title_full_unstemmed	Conjugation Of EGCG And Chitosan NPs As A Novel Nano-Drug Delivery System
title_sort	conjugation of egcg and chitosan nps as a novel nano-drug delivery system
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/eea7ae0db65c4ffcbab365357521e9bf
work_keys_str_mv	AT saferam conjugationofegcgandchitosannpsasanovelnanodrugdeliverysystem AT leporattis conjugationofegcgandchitosannpsasanovelnanodrugdeliverysystem AT josej conjugationofegcgandchitosannpsasanovelnanodrugdeliverysystem AT solimanms conjugationofegcgandchitosannpsasanovelnanodrugdeliverysystem
_version_	1718398157769932800

Conjugation Of EGCG And Chitosan NPs As A Novel Nano-Drug Delivery System

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