Impact of acute ethanol intake on cardiac autonomic regulation

Abstract Acute alcohol consumption may facilitate cardiac arrhythmias underlying the ‘Holiday Heart Syndrome’. Autonomic imbalance is promoting atrial arrhythmias. We analyzed the effects of alcohol on measures of the cardiac autonomic nervous system and their relation to arrhythmias. In 15 healthy...

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Autores principales:	Stefan Brunner, Raphaela Winter, Christina Werzer, Lukas von Stülpnagel, Ina Clasen, Annika Hameder, Andreas Stöver, Matthias Graw, Axel Bauer, Moritz F. Sinner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/eea84573012a4042b020b7cb04f12586
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spelling	oai:doaj.org-article:eea84573012a4042b020b7cb04f125862021-12-02T16:05:54ZImpact of acute ethanol intake on cardiac autonomic regulation10.1038/s41598-021-92767-y2045-2322https://doaj.org/article/eea84573012a4042b020b7cb04f125862021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92767-yhttps://doaj.org/toc/2045-2322Abstract Acute alcohol consumption may facilitate cardiac arrhythmias underlying the ‘Holiday Heart Syndrome’. Autonomic imbalance is promoting atrial arrhythmias. We analyzed the effects of alcohol on measures of the cardiac autonomic nervous system and their relation to arrhythmias. In 15 healthy individuals, alcohol was administered parenterally until a breath alcohol concentration of 0.50 mg/l. High-resolution digital 30-min ECGs were recorded at baseline, at the time of maximum alcohol concentration, and after alcohol concentration returned to near baseline. Using customized software, we assessed periodic repolarization dynamics (PRD), deceleration capacity (DC), standard measures of heart rate variability (SDNN; RMSSD; LF; HF), and standard ECG parameters (mean heart rate; PQ; QRS; QTc interval). At the maximum alcohol concentration, PRD levels were significantly increased compared to baseline [1.92 (IQR 1.14–3.33) deg2 vs. 0.85 (0.69–1.48) deg2; p = 0.001]. PRD levels remained slightly increased when alcohol concentrations returned to baseline. DC levels were significantly decreased at the maximum alcohol concentration compared to baseline [7.79 (5.89–9.62) ms vs. 9.97 (8.20–10.99) ms; p = 0.030], and returned to baseline levels upon reaching baseline levels of alcohol. Standard HRV measures were reduced at maximum alcohol concentration. The mean heart rate increased significantly during alcohol administration. QRS and QTc duration were significantly prolonged, whereas PQ interval showed no change. Our findings revealed an increase of sympathetic activity and a reduction of parasympathetic activity under the influence of alcohol administration, resulting in autonomic imbalance. This imbalance might ultimately trigger arrhythmias underlying the ‘Holiday Heart Syndrome’.Stefan BrunnerRaphaela WinterChristina WerzerLukas von StülpnagelIna ClasenAnnika HamederAndreas StöverMatthias GrawAxel BauerMoritz F. SinnerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stefan Brunner Raphaela Winter Christina Werzer Lukas von Stülpnagel Ina Clasen Annika Hameder Andreas Stöver Matthias Graw Axel Bauer Moritz F. Sinner Impact of acute ethanol intake on cardiac autonomic regulation
description	Abstract Acute alcohol consumption may facilitate cardiac arrhythmias underlying the ‘Holiday Heart Syndrome’. Autonomic imbalance is promoting atrial arrhythmias. We analyzed the effects of alcohol on measures of the cardiac autonomic nervous system and their relation to arrhythmias. In 15 healthy individuals, alcohol was administered parenterally until a breath alcohol concentration of 0.50 mg/l. High-resolution digital 30-min ECGs were recorded at baseline, at the time of maximum alcohol concentration, and after alcohol concentration returned to near baseline. Using customized software, we assessed periodic repolarization dynamics (PRD), deceleration capacity (DC), standard measures of heart rate variability (SDNN; RMSSD; LF; HF), and standard ECG parameters (mean heart rate; PQ; QRS; QTc interval). At the maximum alcohol concentration, PRD levels were significantly increased compared to baseline [1.92 (IQR 1.14–3.33) deg2 vs. 0.85 (0.69–1.48) deg2; p = 0.001]. PRD levels remained slightly increased when alcohol concentrations returned to baseline. DC levels were significantly decreased at the maximum alcohol concentration compared to baseline [7.79 (5.89–9.62) ms vs. 9.97 (8.20–10.99) ms; p = 0.030], and returned to baseline levels upon reaching baseline levels of alcohol. Standard HRV measures were reduced at maximum alcohol concentration. The mean heart rate increased significantly during alcohol administration. QRS and QTc duration were significantly prolonged, whereas PQ interval showed no change. Our findings revealed an increase of sympathetic activity and a reduction of parasympathetic activity under the influence of alcohol administration, resulting in autonomic imbalance. This imbalance might ultimately trigger arrhythmias underlying the ‘Holiday Heart Syndrome’.
format	article
author	Stefan Brunner Raphaela Winter Christina Werzer Lukas von Stülpnagel Ina Clasen Annika Hameder Andreas Stöver Matthias Graw Axel Bauer Moritz F. Sinner
author_facet	Stefan Brunner Raphaela Winter Christina Werzer Lukas von Stülpnagel Ina Clasen Annika Hameder Andreas Stöver Matthias Graw Axel Bauer Moritz F. Sinner
author_sort	Stefan Brunner
title	Impact of acute ethanol intake on cardiac autonomic regulation
title_short	Impact of acute ethanol intake on cardiac autonomic regulation
title_full	Impact of acute ethanol intake on cardiac autonomic regulation
title_fullStr	Impact of acute ethanol intake on cardiac autonomic regulation
title_full_unstemmed	Impact of acute ethanol intake on cardiac autonomic regulation
title_sort	impact of acute ethanol intake on cardiac autonomic regulation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/eea84573012a4042b020b7cb04f12586
work_keys_str_mv	AT stefanbrunner impactofacuteethanolintakeoncardiacautonomicregulation AT raphaelawinter impactofacuteethanolintakeoncardiacautonomicregulation AT christinawerzer impactofacuteethanolintakeoncardiacautonomicregulation AT lukasvonstulpnagel impactofacuteethanolintakeoncardiacautonomicregulation AT inaclasen impactofacuteethanolintakeoncardiacautonomicregulation AT annikahameder impactofacuteethanolintakeoncardiacautonomicregulation AT andreasstover impactofacuteethanolintakeoncardiacautonomicregulation AT matthiasgraw impactofacuteethanolintakeoncardiacautonomicregulation AT axelbauer impactofacuteethanolintakeoncardiacautonomicregulation AT moritzfsinner impactofacuteethanolintakeoncardiacautonomicregulation
_version_	1718385183887982592

Impact of acute ethanol intake on cardiac autonomic regulation

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