Effect of dietary oils on peripheral neuropathy-related endpoints in dietary obese rats

Lawrence Coppey,1 Eric Davidson,1 Hanna Shevalye,1 Michael E Torres,1 Mark A Yorek1–4 1Department of Internal Medicine, University of Iowa, Iowa City, IA, USA; 2Department of Veterans Affairs Iowa City Health Care System, Iowa City, IA, USA; 3Department of Veterans Affairs, Veterans Affair...

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Autores principales:	Coppey L, Davidson E, Shevalye H, Torres ME, Yorek MA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	peripheral neuropathy fish oil omego-3 polyunsaturated fatty acids vascular reactivity nerve conduction velocity Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/eeaaf90622914f40bf16d14b7d28d147
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spelling	oai:doaj.org-article:eeaaf90622914f40bf16d14b7d28d1472021-12-02T02:35:13ZEffect of dietary oils on peripheral neuropathy-related endpoints in dietary obese rats1178-7007https://doaj.org/article/eeaaf90622914f40bf16d14b7d28d1472018-04-01T00:00:00Zhttps://www.dovepress.com/effect-of-dietary-oils-on-peripheral-neuropathy-related-endpoints-in-d-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Lawrence Coppey,1 Eric Davidson,1 Hanna Shevalye,1 Michael E Torres,1 Mark A Yorek1–4 1Department of Internal Medicine, University of Iowa, Iowa City, IA, USA; 2Department of Veterans Affairs Iowa City Health Care System, Iowa City, IA, USA; 3Department of Veterans Affairs, Veterans Affairs Center for the Prevention and Treatment of Visual Loss, Iowa City, IA, USA; 4Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, IA, USA Purpose: This study aimed to determine the effect of dietary oils (olive, safflower, evening primrose, flaxseed, or menhaden) enriched in different mono unsaturated fatty acids or polyunsaturated fatty acids on peripheral neuropathies in diet-induced obese Sprague-Dawley rats.Materials and methods: Rats at 12 weeks of age were fed a high-fat diet (45% kcal) for 16 weeks. Afterward, the rats were fed diets with 50% of the kilocalories of fat derived from lard replaced by the different dietary oils. In addition, a control group fed a standard diet (4% kcal fat) and a high fat fed group (45% kcal) were maintained. The treatment period was 32 weeks. The endpoints evaluated included motor and sensory nerve conduction velocity, thermal sensitivity, innervation of sensory nerves in the cornea and skin, and vascular relaxation by epineurial arterioles.Results: Menhaden oil provided the greatest benefit for improving peripheral nerve damage caused by dietary obesity. Similar results were obtained when we examined acetylcholine-mediated vascular relaxation of epineurial arterioles of the sciatic nerve. Enriching the diets with fatty acids derived from the other oils provided minimal to partial improvements.Conclusion: These studies suggest that omega-3 polyunsaturated fatty acids derived from fish oil could be an effective treatment for neural and vascular complications associated with obesity. Keywords: peripheral neuropathy, fish oil, omega-3 polyunsaturated fatty acids, omega-6 polyunsaturated fatty acids, vascular reactivity, nerve conduction velocityCoppey LDavidson EShevalye HTorres MEYorek MADove Medical Pressarticleperipheral neuropathyfish oilomego-3 polyunsaturated fatty acidsvascular reactivitynerve conduction velocitySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 11, Pp 117-127 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	peripheral neuropathy fish oil omego-3 polyunsaturated fatty acids vascular reactivity nerve conduction velocity Specialties of internal medicine RC581-951
spellingShingle	peripheral neuropathy fish oil omego-3 polyunsaturated fatty acids vascular reactivity nerve conduction velocity Specialties of internal medicine RC581-951 Coppey L Davidson E Shevalye H Torres ME Yorek MA Effect of dietary oils on peripheral neuropathy-related endpoints in dietary obese rats
description	Lawrence Coppey,1 Eric Davidson,1 Hanna Shevalye,1 Michael E Torres,1 Mark A Yorek1–4 1Department of Internal Medicine, University of Iowa, Iowa City, IA, USA; 2Department of Veterans Affairs Iowa City Health Care System, Iowa City, IA, USA; 3Department of Veterans Affairs, Veterans Affairs Center for the Prevention and Treatment of Visual Loss, Iowa City, IA, USA; 4Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, IA, USA Purpose: This study aimed to determine the effect of dietary oils (olive, safflower, evening primrose, flaxseed, or menhaden) enriched in different mono unsaturated fatty acids or polyunsaturated fatty acids on peripheral neuropathies in diet-induced obese Sprague-Dawley rats.Materials and methods: Rats at 12 weeks of age were fed a high-fat diet (45% kcal) for 16 weeks. Afterward, the rats were fed diets with 50% of the kilocalories of fat derived from lard replaced by the different dietary oils. In addition, a control group fed a standard diet (4% kcal fat) and a high fat fed group (45% kcal) were maintained. The treatment period was 32 weeks. The endpoints evaluated included motor and sensory nerve conduction velocity, thermal sensitivity, innervation of sensory nerves in the cornea and skin, and vascular relaxation by epineurial arterioles.Results: Menhaden oil provided the greatest benefit for improving peripheral nerve damage caused by dietary obesity. Similar results were obtained when we examined acetylcholine-mediated vascular relaxation of epineurial arterioles of the sciatic nerve. Enriching the diets with fatty acids derived from the other oils provided minimal to partial improvements.Conclusion: These studies suggest that omega-3 polyunsaturated fatty acids derived from fish oil could be an effective treatment for neural and vascular complications associated with obesity. Keywords: peripheral neuropathy, fish oil, omega-3 polyunsaturated fatty acids, omega-6 polyunsaturated fatty acids, vascular reactivity, nerve conduction velocity
format	article
author	Coppey L Davidson E Shevalye H Torres ME Yorek MA
author_facet	Coppey L Davidson E Shevalye H Torres ME Yorek MA
author_sort	Coppey L
title	Effect of dietary oils on peripheral neuropathy-related endpoints in dietary obese rats
title_short	Effect of dietary oils on peripheral neuropathy-related endpoints in dietary obese rats
title_full	Effect of dietary oils on peripheral neuropathy-related endpoints in dietary obese rats
title_fullStr	Effect of dietary oils on peripheral neuropathy-related endpoints in dietary obese rats
title_full_unstemmed	Effect of dietary oils on peripheral neuropathy-related endpoints in dietary obese rats
title_sort	effect of dietary oils on peripheral neuropathy-related endpoints in dietary obese rats
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/eeaaf90622914f40bf16d14b7d28d147
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Effect of dietary oils on peripheral neuropathy-related endpoints in dietary obese rats

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