K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression

Hypoxia-induced transcriptional responses mediated by HIF-1a are regulated through the ubiquitin-dependent pathway to control HIF-1a stability. Here the authors show that the deubiquitinase HAUSP modulates the stability of HIF-1a and K63-polyubiquitinated HAUSP serves as an anchor for HIF-1a-induced...

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Autores principales:	Han-Tsang Wu, Yi-Chih Kuo, Jung-Jyh Hung, Chi-Hung Huang, Wei-Yi Chen, Teh-Ying Chou, Yeh Chen, Yi-Ju Chen, Yu-Ju Chen, Wei-Chung Cheng, Shu-Chun Teng, Kou-Juey Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eeab853bf97f403e830ddd4b444d9412
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spelling	oai:doaj.org-article:eeab853bf97f403e830ddd4b444d94122021-12-02T17:32:20ZK63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression10.1038/ncomms136442041-1723https://doaj.org/article/eeab853bf97f403e830ddd4b444d94122016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13644https://doaj.org/toc/2041-1723Hypoxia-induced transcriptional responses mediated by HIF-1a are regulated through the ubiquitin-dependent pathway to control HIF-1a stability. Here the authors show that the deubiquitinase HAUSP modulates the stability of HIF-1a and K63-polyubiquitinated HAUSP serves as an anchor for HIF-1a-induced gene transcription.Han-Tsang WuYi-Chih KuoJung-Jyh HungChi-Hung HuangWei-Yi ChenTeh-Ying ChouYeh ChenYi-Ju ChenYu-Ju ChenWei-Chung ChengShu-Chun TengKou-Juey WuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Han-Tsang Wu Yi-Chih Kuo Jung-Jyh Hung Chi-Hung Huang Wei-Yi Chen Teh-Ying Chou Yeh Chen Yi-Ju Chen Yu-Ju Chen Wei-Chung Cheng Shu-Chun Teng Kou-Juey Wu K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression
description	Hypoxia-induced transcriptional responses mediated by HIF-1a are regulated through the ubiquitin-dependent pathway to control HIF-1a stability. Here the authors show that the deubiquitinase HAUSP modulates the stability of HIF-1a and K63-polyubiquitinated HAUSP serves as an anchor for HIF-1a-induced gene transcription.
format	article
author	Han-Tsang Wu Yi-Chih Kuo Jung-Jyh Hung Chi-Hung Huang Wei-Yi Chen Teh-Ying Chou Yeh Chen Yi-Ju Chen Yu-Ju Chen Wei-Chung Cheng Shu-Chun Teng Kou-Juey Wu
author_facet	Han-Tsang Wu Yi-Chih Kuo Jung-Jyh Hung Chi-Hung Huang Wei-Yi Chen Teh-Ying Chou Yeh Chen Yi-Ju Chen Yu-Ju Chen Wei-Chung Cheng Shu-Chun Teng Kou-Juey Wu
author_sort	Han-Tsang Wu
title	K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression
title_short	K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression
title_full	K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression
title_fullStr	K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression
title_full_unstemmed	K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression
title_sort	k63-polyubiquitinated hausp deubiquitinates hif-1α and dictates h3k56 acetylation promoting hypoxia-induced tumour progression
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/eeab853bf97f403e830ddd4b444d9412
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K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression

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