SIGNIFICANCE OF SINGLE-NUCLEOTIDE POLYMORPHISMS 2578C>A AND +936C>T IN THE VEGF GENE FOR EFFICIENCY EVALUAT ION OF ANTICANCER IMMUNOTHERAPY IN PAT IENTS WITH METASTAT IC SKIN MELANOMA

Abstract. Increased VEGF levels in cancer patients may be associated with decreased number of dendritic cells (DCs) and lower DC function. We investigated whether VEGF gene polymorphisms -2578C>A (rs699947) and +936C>T (rs3025039) are associated with efficacy of autologous DC-based imm...

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Autores principales:	Yu. A. Khochenkova, G. Z. Chkadua, I. V. Samoylenko, T. F. Malivanova, I. N. Mikhailova, L. V. Demidov, E. V. Stepanova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	vegf snps dendritic cells anticancer immunotherapy metastatic melanoma Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/eeb026a56774434f9e4bf5856688d7d3
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spelling	oai:doaj.org-article:eeb026a56774434f9e4bf5856688d7d32021-11-18T08:03:43ZSIGNIFICANCE OF SINGLE-NUCLEOTIDE POLYMORPHISMS 2578C>A AND +936C>T IN THE VEGF GENE FOR EFFICIENCY EVALUAT ION OF ANTICANCER IMMUNOTHERAPY IN PAT IENTS WITH METASTAT IC SKIN MELANOMA1563-06252313-741X10.15789/1563-0625-2013-6-563-570https://doaj.org/article/eeb026a56774434f9e4bf5856688d7d32014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/671https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Increased VEGF levels in cancer patients may be associated with decreased number of dendritic cells (DCs) and lower DC function. We investigated whether VEGF gene polymorphisms -2578C>A (rs699947) and +936C>T (rs3025039) are associated with efficacy of autologous DC-based immunotherapy in patients with malignant melanoma. Evaluation of VEGFR-1 and VEGFR-2 expression on mature monocyte-derived DC revealed a decreased VEGFR-1 level (18.9±0.7% on peripheral blood monocytes, as compared to 6.3±0.6% on mature DCs) and non-changed VEGFR-2 expression (13.1±0.4% and 15.9±0.4%, respectively). The АА genotype frequency of -2578C>A (rs699947) polymorphism of VEGF gene was 46.1%. АС heterozygous state was found in 38.5%, and СС, in 15.4% of cases. The VEGF -2578 AC and AA genotypes were directly associated with progression-free survival and efficacy of treatment. The median progression-free survival of patients with -2578 AA and AC genotypes was a significantly longer (8.4 months), as compared with that of patients with CC genotypes (2.7 months), p = 0.002. The established relationship between genotype and efficacy of immunotherapy can be used to develop modern methods for predicting melanoma progression and to personalize immunotherapy including a combination with antiangiogenic therapy.Yu. A. KhochenkovaG. Z. ChkaduaI. V. SamoylenkoT. F. MalivanovaI. N. MikhailovaL. V. DemidovE. V. StepanovaSPb RAACIarticlevegfsnpsdendritic cellsanticancer immunotherapymetastatic melanomaImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 15, Iss 6, Pp 563-570 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	vegf snps dendritic cells anticancer immunotherapy metastatic melanoma Immunologic diseases. Allergy RC581-607
spellingShingle	vegf snps dendritic cells anticancer immunotherapy metastatic melanoma Immunologic diseases. Allergy RC581-607 Yu. A. Khochenkova G. Z. Chkadua I. V. Samoylenko T. F. Malivanova I. N. Mikhailova L. V. Demidov E. V. Stepanova SIGNIFICANCE OF SINGLE-NUCLEOTIDE POLYMORPHISMS 2578C>A AND +936C>T IN THE VEGF GENE FOR EFFICIENCY EVALUAT ION OF ANTICANCER IMMUNOTHERAPY IN PAT IENTS WITH METASTAT IC SKIN MELANOMA
description	Abstract. Increased VEGF levels in cancer patients may be associated with decreased number of dendritic cells (DCs) and lower DC function. We investigated whether VEGF gene polymorphisms -2578C>A (rs699947) and +936C>T (rs3025039) are associated with efficacy of autologous DC-based immunotherapy in patients with malignant melanoma. Evaluation of VEGFR-1 and VEGFR-2 expression on mature monocyte-derived DC revealed a decreased VEGFR-1 level (18.9±0.7% on peripheral blood monocytes, as compared to 6.3±0.6% on mature DCs) and non-changed VEGFR-2 expression (13.1±0.4% and 15.9±0.4%, respectively). The АА genotype frequency of -2578C>A (rs699947) polymorphism of VEGF gene was 46.1%. АС heterozygous state was found in 38.5%, and СС, in 15.4% of cases. The VEGF -2578 AC and AA genotypes were directly associated with progression-free survival and efficacy of treatment. The median progression-free survival of patients with -2578 AA and AC genotypes was a significantly longer (8.4 months), as compared with that of patients with CC genotypes (2.7 months), p = 0.002. The established relationship between genotype and efficacy of immunotherapy can be used to develop modern methods for predicting melanoma progression and to personalize immunotherapy including a combination with antiangiogenic therapy.
format	article
author	Yu. A. Khochenkova G. Z. Chkadua I. V. Samoylenko T. F. Malivanova I. N. Mikhailova L. V. Demidov E. V. Stepanova
author_facet	Yu. A. Khochenkova G. Z. Chkadua I. V. Samoylenko T. F. Malivanova I. N. Mikhailova L. V. Demidov E. V. Stepanova
author_sort	Yu. A. Khochenkova
title	SIGNIFICANCE OF SINGLE-NUCLEOTIDE POLYMORPHISMS 2578C>A AND +936C>T IN THE VEGF GENE FOR EFFICIENCY EVALUAT ION OF ANTICANCER IMMUNOTHERAPY IN PAT IENTS WITH METASTAT IC SKIN MELANOMA
title_short	SIGNIFICANCE OF SINGLE-NUCLEOTIDE POLYMORPHISMS 2578C>A AND +936C>T IN THE VEGF GENE FOR EFFICIENCY EVALUAT ION OF ANTICANCER IMMUNOTHERAPY IN PAT IENTS WITH METASTAT IC SKIN MELANOMA
title_full	SIGNIFICANCE OF SINGLE-NUCLEOTIDE POLYMORPHISMS 2578C>A AND +936C>T IN THE VEGF GENE FOR EFFICIENCY EVALUAT ION OF ANTICANCER IMMUNOTHERAPY IN PAT IENTS WITH METASTAT IC SKIN MELANOMA
title_fullStr	SIGNIFICANCE OF SINGLE-NUCLEOTIDE POLYMORPHISMS 2578C>A AND +936C>T IN THE VEGF GENE FOR EFFICIENCY EVALUAT ION OF ANTICANCER IMMUNOTHERAPY IN PAT IENTS WITH METASTAT IC SKIN MELANOMA
title_full_unstemmed	SIGNIFICANCE OF SINGLE-NUCLEOTIDE POLYMORPHISMS 2578C>A AND +936C>T IN THE VEGF GENE FOR EFFICIENCY EVALUAT ION OF ANTICANCER IMMUNOTHERAPY IN PAT IENTS WITH METASTAT IC SKIN MELANOMA
title_sort	significance of single-nucleotide polymorphisms 2578c>a and +936c>t in the vegf gene for efficiency evaluat ion of anticancer immunotherapy in pat ients with metastat ic skin melanoma
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/eeb026a56774434f9e4bf5856688d7d3
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_version_	1718422455142318080

SIGNIFICANCE OF SINGLE-NUCLEOTIDE POLYMORPHISMS 2578C>A AND +936C>T IN THE VEGF GENE FOR EFFICIENCY EVALUAT ION OF ANTICANCER IMMUNOTHERAPY IN PAT IENTS WITH METASTAT IC SKIN MELANOMA

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