Decrease of SYNGAP1 in GABAergic cells impairs inhibitory synapse connectivity, synaptic inhibition and cognitive function

Decrease of SYNGAP1 in GABAergic cells impairs inhibitory synapse connectivity, synaptic inhibition and cognitive function

Glutamatergic signalling regulation by Syngap1 has been linked to intellectual disabilities. Here, the authors find Syngap1 also regulates cortical GABAergic synaptic signalling development and that this reduced inhibitory signalling contributes to cognitive deficits in a mouse model.

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Autores principales: Martin H. Berryer, Bidisha Chattopadhyaya, Paul Xing, Ilse Riebe, Ciprian Bosoi, Nathalie Sanon, Judith Antoine-Bertrand, Maxime Lévesque, Massimo Avoli, Fadi F. Hamdan, Lionel Carmant, Nathalie Lamarche-Vane, Jean-Claude Lacaille, Jacques L. Michaud, Graziella Di Cristo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/eeb13416b0ae4f06aee639606c693a20
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spelling oai:doaj.org-article:eeb13416b0ae4f06aee639606c693a202021-12-02T17:32:04ZDecrease of SYNGAP1 in GABAergic cells impairs inhibitory synapse connectivity, synaptic inhibition and cognitive function10.1038/ncomms133402041-1723https://doaj.org/article/eeb13416b0ae4f06aee639606c693a202016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13340https://doaj.org/toc/2041-1723Glutamatergic signalling regulation by Syngap1 has been linked to intellectual disabilities. Here, the authors find Syngap1 also regulates cortical GABAergic synaptic signalling development and that this reduced inhibitory signalling contributes to cognitive deficits in a mouse model.Martin H. BerryerBidisha ChattopadhyayaPaul XingIlse RiebeCiprian BosoiNathalie SanonJudith Antoine-BertrandMaxime LévesqueMassimo AvoliFadi F. HamdanLionel CarmantNathalie Lamarche-VaneJean-Claude LacailleJacques L. MichaudGraziella Di CristoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Martin H. Berryer
Bidisha Chattopadhyaya
Paul Xing
Ilse Riebe
Ciprian Bosoi
Nathalie Sanon
Judith Antoine-Bertrand
Maxime Lévesque
Massimo Avoli
Fadi F. Hamdan
Lionel Carmant
Nathalie Lamarche-Vane
Jean-Claude Lacaille
Jacques L. Michaud
Graziella Di Cristo
Decrease of SYNGAP1 in GABAergic cells impairs inhibitory synapse connectivity, synaptic inhibition and cognitive function
description Glutamatergic signalling regulation by Syngap1 has been linked to intellectual disabilities. Here, the authors find Syngap1 also regulates cortical GABAergic synaptic signalling development and that this reduced inhibitory signalling contributes to cognitive deficits in a mouse model.
format article
author Martin H. Berryer
Bidisha Chattopadhyaya
Paul Xing
Ilse Riebe
Ciprian Bosoi
Nathalie Sanon
Judith Antoine-Bertrand
Maxime Lévesque
Massimo Avoli
Fadi F. Hamdan
Lionel Carmant
Nathalie Lamarche-Vane
Jean-Claude Lacaille
Jacques L. Michaud
Graziella Di Cristo
author_facet Martin H. Berryer
Bidisha Chattopadhyaya
Paul Xing
Ilse Riebe
Ciprian Bosoi
Nathalie Sanon
Judith Antoine-Bertrand
Maxime Lévesque
Massimo Avoli
Fadi F. Hamdan
Lionel Carmant
Nathalie Lamarche-Vane
Jean-Claude Lacaille
Jacques L. Michaud
Graziella Di Cristo
author_sort Martin H. Berryer
title Decrease of SYNGAP1 in GABAergic cells impairs inhibitory synapse connectivity, synaptic inhibition and cognitive function
title_short Decrease of SYNGAP1 in GABAergic cells impairs inhibitory synapse connectivity, synaptic inhibition and cognitive function
title_full Decrease of SYNGAP1 in GABAergic cells impairs inhibitory synapse connectivity, synaptic inhibition and cognitive function
title_fullStr Decrease of SYNGAP1 in GABAergic cells impairs inhibitory synapse connectivity, synaptic inhibition and cognitive function
title_full_unstemmed Decrease of SYNGAP1 in GABAergic cells impairs inhibitory synapse connectivity, synaptic inhibition and cognitive function
title_sort decrease of syngap1 in gabaergic cells impairs inhibitory synapse connectivity, synaptic inhibition and cognitive function
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/eeb13416b0ae4f06aee639606c693a20
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