«DIARISK» — the first national prediabetes and diabetes mellitus type 2 risk calculator

BACKGRAUND: The need to create a national questionnaire for screening the population for disorders of carbohydrate metabolism.AIMS: Develop a highly specific and sensitive questionnaire-calculator of the risk of prediabetes (PreD) and diabetes mellitus type 2 (DM2T) based on depersonalized data of i...

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Autores principales: Marina V. Shestakova, Alexey S. Kolbin, Gagik R. Galstyan, Maria A. Arepeva, Ekaterina L. Zaitseva, Alexander Y. Mayorov, Oleg I. Karpov, Maxim A. Proskurin, Aleksey A. Kurylev, Ivan I. Dedov
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RU
Publicado: Endocrinology Research Centre 2021
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Acceso en línea:https://doaj.org/article/eeb2a27bf65d4751ac308bf0878f96cb
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spelling oai:doaj.org-article:eeb2a27bf65d4751ac308bf0878f96cb2021-11-14T09:00:23Z«DIARISK» — the first national prediabetes and diabetes mellitus type 2 risk calculator2072-03512072-037810.14341/DM12570https://doaj.org/article/eeb2a27bf65d4751ac308bf0878f96cb2021-01-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/12570https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378BACKGRAUND: The need to create a national questionnaire for screening the population for disorders of carbohydrate metabolism.AIMS: Develop a highly specific and sensitive questionnaire-calculator of the risk of prediabetes (PreD) and diabetes mellitus type 2 (DM2T) based on depersonalized data of individuals who have these diagnoses confirmed in the national epidemiological study NATION.METHODS: The express method of prediabetes (PreD) and diabetes mellitus type 2 (DM2T) risks has been created, validated and proposed for clinical usage for the first time in the Russian Federation, it was based of NATION epidemiologic study database (more than 26 000 participants). The following mathematical instruments have been used: mathematic modelling, main components methodology, binary variables, correlation analysis and single-factor analysis of variance.RESULTS: Highest coefficients of logistic regression for PreD (p<0.05) were identified for age — ≥52 years old for women and ≥59 years old for men (1,48); body mass index ≥31 (0.75); waist circumference ≥100 сm for women and ≥112 cm for men (0.90). In the same time coefficients for DM2T were for for age — ≥52 years old for women and ≥59 years old for men (1,24); body mass index ≥31 (1,19), high blood fasting glucose analysis in the past (1,37); waist circumference / hip circumference ratio ≥0.85 for women and ≥0.92 for men (1,05), high blood pressure (0.69). Correlation coefficients were taken into account and score has been used for specialized questionnaire creation. Sensitivity and specificity for PreD were 83,8% and 59,3% accordingly, for DM2T — 85,4% and 73,6% accordingly. DM2T may be suspected when total score of questionnaire is 11 and higher, and PreD — when total score will be ≥7 and <11.CONCLUSIONS: The calculator based on questionnaire (DIARISK) allows to separate of potential patient for PreD and DM2T confirmation during first examination or dispanserization. A patent for innovation has been issued.Marina V. ShestakovaAlexey S. KolbinGagik R. GalstyanMaria A. ArepevaEkaterina L. ZaitsevaAlexander Y. MayorovOleg I. KarpovMaxim A. ProskurinAleksey A. KurylevIvan I. DedovEndocrinology Research Centrearticlediabetes mellitus type 2, epidemiology, diagnosisNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 23, Iss 5, Pp 404-411 (2021)
institution DOAJ
collection DOAJ
language EN
RU
topic diabetes mellitus type 2, epidemiology, diagnosis
Nutritional diseases. Deficiency diseases
RC620-627
spellingShingle diabetes mellitus type 2, epidemiology, diagnosis
Nutritional diseases. Deficiency diseases
RC620-627
Marina V. Shestakova
Alexey S. Kolbin
Gagik R. Galstyan
Maria A. Arepeva
Ekaterina L. Zaitseva
Alexander Y. Mayorov
Oleg I. Karpov
Maxim A. Proskurin
Aleksey A. Kurylev
Ivan I. Dedov
«DIARISK» — the first national prediabetes and diabetes mellitus type 2 risk calculator
description BACKGRAUND: The need to create a national questionnaire for screening the population for disorders of carbohydrate metabolism.AIMS: Develop a highly specific and sensitive questionnaire-calculator of the risk of prediabetes (PreD) and diabetes mellitus type 2 (DM2T) based on depersonalized data of individuals who have these diagnoses confirmed in the national epidemiological study NATION.METHODS: The express method of prediabetes (PreD) and diabetes mellitus type 2 (DM2T) risks has been created, validated and proposed for clinical usage for the first time in the Russian Federation, it was based of NATION epidemiologic study database (more than 26 000 participants). The following mathematical instruments have been used: mathematic modelling, main components methodology, binary variables, correlation analysis and single-factor analysis of variance.RESULTS: Highest coefficients of logistic regression for PreD (p<0.05) were identified for age — ≥52 years old for women and ≥59 years old for men (1,48); body mass index ≥31 (0.75); waist circumference ≥100 сm for women and ≥112 cm for men (0.90). In the same time coefficients for DM2T were for for age — ≥52 years old for women and ≥59 years old for men (1,24); body mass index ≥31 (1,19), high blood fasting glucose analysis in the past (1,37); waist circumference / hip circumference ratio ≥0.85 for women and ≥0.92 for men (1,05), high blood pressure (0.69). Correlation coefficients were taken into account and score has been used for specialized questionnaire creation. Sensitivity and specificity for PreD were 83,8% and 59,3% accordingly, for DM2T — 85,4% and 73,6% accordingly. DM2T may be suspected when total score of questionnaire is 11 and higher, and PreD — when total score will be ≥7 and <11.CONCLUSIONS: The calculator based on questionnaire (DIARISK) allows to separate of potential patient for PreD and DM2T confirmation during first examination or dispanserization. A patent for innovation has been issued.
format article
author Marina V. Shestakova
Alexey S. Kolbin
Gagik R. Galstyan
Maria A. Arepeva
Ekaterina L. Zaitseva
Alexander Y. Mayorov
Oleg I. Karpov
Maxim A. Proskurin
Aleksey A. Kurylev
Ivan I. Dedov
author_facet Marina V. Shestakova
Alexey S. Kolbin
Gagik R. Galstyan
Maria A. Arepeva
Ekaterina L. Zaitseva
Alexander Y. Mayorov
Oleg I. Karpov
Maxim A. Proskurin
Aleksey A. Kurylev
Ivan I. Dedov
author_sort Marina V. Shestakova
title «DIARISK» — the first national prediabetes and diabetes mellitus type 2 risk calculator
title_short «DIARISK» — the first national prediabetes and diabetes mellitus type 2 risk calculator
title_full «DIARISK» — the first national prediabetes and diabetes mellitus type 2 risk calculator
title_fullStr «DIARISK» — the first national prediabetes and diabetes mellitus type 2 risk calculator
title_full_unstemmed «DIARISK» — the first national prediabetes and diabetes mellitus type 2 risk calculator
title_sort «diarisk» — the first national prediabetes and diabetes mellitus type 2 risk calculator
publisher Endocrinology Research Centre
publishDate 2021
url https://doaj.org/article/eeb2a27bf65d4751ac308bf0878f96cb
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