ApoCIII enrichment in HDL impairs HDL-mediated cholesterol efflux capacity

Abstract Apolipoprotein CIII (apoCIII) has been reported to be tightly associated with triglyceride metabolism and the susceptibility to coronary artery disease (CAD). Besides, apoCIII has also been found to affect the anti-apoptotic effects of HDL. However, the effect of apoCIII on HDL-mediated cho...

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Autores principales:	Mengdie Luo, Aiying Liu, Shuai Wang, Tianle Wang, Die Hu, Sha Wu, Daoquan Peng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/eeb2a44dbea143e8b008f8f207707678
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spelling	oai:doaj.org-article:eeb2a44dbea143e8b008f8f2077076782021-12-02T12:32:18ZApoCIII enrichment in HDL impairs HDL-mediated cholesterol efflux capacity10.1038/s41598-017-02601-72045-2322https://doaj.org/article/eeb2a44dbea143e8b008f8f2077076782017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02601-7https://doaj.org/toc/2045-2322Abstract Apolipoprotein CIII (apoCIII) has been reported to be tightly associated with triglyceride metabolism and the susceptibility to coronary artery disease (CAD). Besides, apoCIII has also been found to affect the anti-apoptotic effects of HDL. However, the effect of apoCIII on HDL-mediated cholesterol efflux, the crucial function of HDL, has not been reported. A hospital-based case-control study was conducted to compare the apoCIII distribution in lipoproteins between CAD patients and nonCAD controls and to explore the relationship between HDL-associated apoCIII (apoCIIIHDL) and HDL-mediated cholesterol efflux. One hundred forty CAD patients and nighty nine nonCAD controls were included. Plasma apoCIII, apoCIIIHDL and cholesterol efflux capacity was measured. The apoCIIIHDL ratio (apoCIIIHDL over plasma apoCIII) was significantly higher in CAD patients than that in control group (0.52 ± 0.24 vs. 0.43 ± 0.22, P = 0.004). Both apoCIIIHDL and apoCIIIHDL ratio were inversely correlated with cholesterol efflux capacity (r = −0.241, P = 0.0002; r = −0.318, P < 0.0001, respectively). Stepwise multiple regression analysis revealed that the apoCIIIHDL ratio was an independent contributor to HDL-mediated cholesterol efflux capacity (standardized β = −0.325, P < 0.001). This study indicates that the presence of apoCIII in HDL may affect HDL-mediated cholesterol efflux capacity, implying the alternative role of apoCIII in the atherogenesis.Mengdie LuoAiying LiuShuai WangTianle WangDie HuSha WuDaoquan PengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mengdie Luo Aiying Liu Shuai Wang Tianle Wang Die Hu Sha Wu Daoquan Peng ApoCIII enrichment in HDL impairs HDL-mediated cholesterol efflux capacity
description	Abstract Apolipoprotein CIII (apoCIII) has been reported to be tightly associated with triglyceride metabolism and the susceptibility to coronary artery disease (CAD). Besides, apoCIII has also been found to affect the anti-apoptotic effects of HDL. However, the effect of apoCIII on HDL-mediated cholesterol efflux, the crucial function of HDL, has not been reported. A hospital-based case-control study was conducted to compare the apoCIII distribution in lipoproteins between CAD patients and nonCAD controls and to explore the relationship between HDL-associated apoCIII (apoCIIIHDL) and HDL-mediated cholesterol efflux. One hundred forty CAD patients and nighty nine nonCAD controls were included. Plasma apoCIII, apoCIIIHDL and cholesterol efflux capacity was measured. The apoCIIIHDL ratio (apoCIIIHDL over plasma apoCIII) was significantly higher in CAD patients than that in control group (0.52 ± 0.24 vs. 0.43 ± 0.22, P = 0.004). Both apoCIIIHDL and apoCIIIHDL ratio were inversely correlated with cholesterol efflux capacity (r = −0.241, P = 0.0002; r = −0.318, P < 0.0001, respectively). Stepwise multiple regression analysis revealed that the apoCIIIHDL ratio was an independent contributor to HDL-mediated cholesterol efflux capacity (standardized β = −0.325, P < 0.001). This study indicates that the presence of apoCIII in HDL may affect HDL-mediated cholesterol efflux capacity, implying the alternative role of apoCIII in the atherogenesis.
format	article
author	Mengdie Luo Aiying Liu Shuai Wang Tianle Wang Die Hu Sha Wu Daoquan Peng
author_facet	Mengdie Luo Aiying Liu Shuai Wang Tianle Wang Die Hu Sha Wu Daoquan Peng
author_sort	Mengdie Luo
title	ApoCIII enrichment in HDL impairs HDL-mediated cholesterol efflux capacity
title_short	ApoCIII enrichment in HDL impairs HDL-mediated cholesterol efflux capacity
title_full	ApoCIII enrichment in HDL impairs HDL-mediated cholesterol efflux capacity
title_fullStr	ApoCIII enrichment in HDL impairs HDL-mediated cholesterol efflux capacity
title_full_unstemmed	ApoCIII enrichment in HDL impairs HDL-mediated cholesterol efflux capacity
title_sort	apociii enrichment in hdl impairs hdl-mediated cholesterol efflux capacity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/eeb2a44dbea143e8b008f8f207707678
work_keys_str_mv	AT mengdieluo apociiienrichmentinhdlimpairshdlmediatedcholesteroleffluxcapacity AT aiyingliu apociiienrichmentinhdlimpairshdlmediatedcholesteroleffluxcapacity AT shuaiwang apociiienrichmentinhdlimpairshdlmediatedcholesteroleffluxcapacity AT tianlewang apociiienrichmentinhdlimpairshdlmediatedcholesteroleffluxcapacity AT diehu apociiienrichmentinhdlimpairshdlmediatedcholesteroleffluxcapacity AT shawu apociiienrichmentinhdlimpairshdlmediatedcholesteroleffluxcapacity AT daoquanpeng apociiienrichmentinhdlimpairshdlmediatedcholesteroleffluxcapacity
_version_	1718394130619432960

ApoCIII enrichment in HDL impairs HDL-mediated cholesterol efflux capacity

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