Logopenic and nonfluent variants of primary progressive aphasia are differentiated by acoustic measures of speech production.

Differentiation of logopenic (lvPPA) and nonfluent/agrammatic (nfvPPA) variants of Primary Progressive Aphasia is important yet remains challenging since it hinges on expert based evaluation of speech and language production. In this study acoustic measures of speech in conjunction with voxel-based...

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Autores principales:	Kirrie J Ballard, Sharon Savage, Cristian E Leyton, Adam P Vogel, Michael Hornberger, John R Hodges
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/eeb4aa0388b547feb1ed5dae60e89589
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spelling	oai:doaj.org-article:eeb4aa0388b547feb1ed5dae60e895892021-11-18T08:30:28ZLogopenic and nonfluent variants of primary progressive aphasia are differentiated by acoustic measures of speech production.1932-620310.1371/journal.pone.0089864https://doaj.org/article/eeb4aa0388b547feb1ed5dae60e895892014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24587083/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Differentiation of logopenic (lvPPA) and nonfluent/agrammatic (nfvPPA) variants of Primary Progressive Aphasia is important yet remains challenging since it hinges on expert based evaluation of speech and language production. In this study acoustic measures of speech in conjunction with voxel-based morphometry were used to determine the success of the measures as an adjunct to diagnosis and to explore the neural basis of apraxia of speech in nfvPPA. Forty-one patients (21 lvPPA, 20 nfvPPA) were recruited from a consecutive sample with suspected frontotemporal dementia. Patients were diagnosed using the current gold-standard of expert perceptual judgment, based on presence/absence of particular speech features during speaking tasks. Seventeen healthy age-matched adults served as controls. MRI scans were available for 11 control and 37 PPA cases; 23 of the PPA cases underwent amyloid ligand PET imaging. Measures, corresponding to perceptual features of apraxia of speech, were periods of silence during reading and relative vowel duration and intensity in polysyllable word repetition. Discriminant function analyses revealed that a measure of relative vowel duration differentiated nfvPPA cases from both control and lvPPA cases (r(2) = 0.47) with 88% agreement with expert judgment of presence of apraxia of speech in nfvPPA cases. VBM analysis showed that relative vowel duration covaried with grey matter intensity in areas critical for speech motor planning and programming: precentral gyrus, supplementary motor area and inferior frontal gyrus bilaterally, only affected in the nfvPPA group. This bilateral involvement of frontal speech networks in nfvPPA potentially affects access to compensatory mechanisms involving right hemisphere homologues. Measures of silences during reading also discriminated the PPA and control groups, but did not increase predictive accuracy. Findings suggest that a measure of relative vowel duration from of a polysyllable word repetition task may be sufficient for detecting most cases of apraxia of speech and distinguishing between nfvPPA and lvPPA.Kirrie J BallardSharon SavageCristian E LeytonAdam P VogelMichael HornbergerJohn R HodgesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e89864 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kirrie J Ballard Sharon Savage Cristian E Leyton Adam P Vogel Michael Hornberger John R Hodges Logopenic and nonfluent variants of primary progressive aphasia are differentiated by acoustic measures of speech production.
description	Differentiation of logopenic (lvPPA) and nonfluent/agrammatic (nfvPPA) variants of Primary Progressive Aphasia is important yet remains challenging since it hinges on expert based evaluation of speech and language production. In this study acoustic measures of speech in conjunction with voxel-based morphometry were used to determine the success of the measures as an adjunct to diagnosis and to explore the neural basis of apraxia of speech in nfvPPA. Forty-one patients (21 lvPPA, 20 nfvPPA) were recruited from a consecutive sample with suspected frontotemporal dementia. Patients were diagnosed using the current gold-standard of expert perceptual judgment, based on presence/absence of particular speech features during speaking tasks. Seventeen healthy age-matched adults served as controls. MRI scans were available for 11 control and 37 PPA cases; 23 of the PPA cases underwent amyloid ligand PET imaging. Measures, corresponding to perceptual features of apraxia of speech, were periods of silence during reading and relative vowel duration and intensity in polysyllable word repetition. Discriminant function analyses revealed that a measure of relative vowel duration differentiated nfvPPA cases from both control and lvPPA cases (r(2) = 0.47) with 88% agreement with expert judgment of presence of apraxia of speech in nfvPPA cases. VBM analysis showed that relative vowel duration covaried with grey matter intensity in areas critical for speech motor planning and programming: precentral gyrus, supplementary motor area and inferior frontal gyrus bilaterally, only affected in the nfvPPA group. This bilateral involvement of frontal speech networks in nfvPPA potentially affects access to compensatory mechanisms involving right hemisphere homologues. Measures of silences during reading also discriminated the PPA and control groups, but did not increase predictive accuracy. Findings suggest that a measure of relative vowel duration from of a polysyllable word repetition task may be sufficient for detecting most cases of apraxia of speech and distinguishing between nfvPPA and lvPPA.
format	article
author	Kirrie J Ballard Sharon Savage Cristian E Leyton Adam P Vogel Michael Hornberger John R Hodges
author_facet	Kirrie J Ballard Sharon Savage Cristian E Leyton Adam P Vogel Michael Hornberger John R Hodges
author_sort	Kirrie J Ballard
title	Logopenic and nonfluent variants of primary progressive aphasia are differentiated by acoustic measures of speech production.
title_short	Logopenic and nonfluent variants of primary progressive aphasia are differentiated by acoustic measures of speech production.
title_full	Logopenic and nonfluent variants of primary progressive aphasia are differentiated by acoustic measures of speech production.
title_fullStr	Logopenic and nonfluent variants of primary progressive aphasia are differentiated by acoustic measures of speech production.
title_full_unstemmed	Logopenic and nonfluent variants of primary progressive aphasia are differentiated by acoustic measures of speech production.
title_sort	logopenic and nonfluent variants of primary progressive aphasia are differentiated by acoustic measures of speech production.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/eeb4aa0388b547feb1ed5dae60e89589
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Logopenic and nonfluent variants of primary progressive aphasia are differentiated by acoustic measures of speech production.

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