Adverse events of extracorporeal ultrasound-guided high intensity focused ultrasound therapy.

<h4>Background</h4>High-intensity focused ultrasound (HIFU) is considered to be an alternative to surgery. Extracorporeal ultrasound-guided HIFU (USgFU) has been clinically used to treat solid tumors. Preliminary trials in a small sample of a Western population suggested that this modali...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tinghe Yu, Jun Luo
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/eeb9cd3e00aa4cdcbc30d497496bfcab
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:eeb9cd3e00aa4cdcbc30d497496bfcab
record_format	dspace
spelling	oai:doaj.org-article:eeb9cd3e00aa4cdcbc30d497496bfcab2021-11-18T07:32:24ZAdverse events of extracorporeal ultrasound-guided high intensity focused ultrasound therapy.1932-620310.1371/journal.pone.0026110https://doaj.org/article/eeb9cd3e00aa4cdcbc30d497496bfcab2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22194777/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>High-intensity focused ultrasound (HIFU) is considered to be an alternative to surgery. Extracorporeal ultrasound-guided HIFU (USgFU) has been clinically used to treat solid tumors. Preliminary trials in a small sample of a Western population suggested that this modality was safe. Most trials are performed in China thereby providing comprehensive data for understanding the safety profile. The aim of this study was to evaluate adverse events of USgFU therapy.<h4>Methods and findings</h4>Clinical data were searched in 2 Chinese databases. Adverse events of USgFU were summarized and compared with those of magnetic resonance-guided HIFU (MRgFU; for uterine, bone or breast tumor) and transrectal ultrasound-guided HIFU (for prostate cancer or benign prostate hyperplasia). USgFU treatment was performed using 7 types of device. Side effects were evaluated in 13262 cases. There were fewer adverse events in benign lesions than in malignant lesions (11.81% vs. 21.65%, p<0.0001). Rates of adverse events greatly varied between the disease types (0-280%, p<0.0001) and between the applied HIFU devices in both malignant (10.58-44.38%, p<0.0001) and benign lesions (1.67-17.57%, p<0.0001). Chronological analysis did not demonstrate a decrease in the rate of adverse events. Based upon evaluable adverse events, incidences in USgFU were consistent with those in MRgFU or transrectal HIFU. Some side effects frequently occurred following transrectal HIFU were not reported in USgFU. Several events including intrahepatic metastasis, intraoperative high fever, and occlusions of the superior mesenteric artery should be of particular concern because they have not been previously noted. The types of adverse events suggested that they were ultrasonic lesions.<h4>Conclusion</h4>The frequency of adverse events depended on the location of the lesion and the type of HIFU device; however, side effects of USgFU were not yet understood. USgFU did not decrease the incidence of adverse events compared with MRgFU.Tinghe YuJun LuoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 12, p e26110 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tinghe Yu Jun Luo Adverse events of extracorporeal ultrasound-guided high intensity focused ultrasound therapy.
description	<h4>Background</h4>High-intensity focused ultrasound (HIFU) is considered to be an alternative to surgery. Extracorporeal ultrasound-guided HIFU (USgFU) has been clinically used to treat solid tumors. Preliminary trials in a small sample of a Western population suggested that this modality was safe. Most trials are performed in China thereby providing comprehensive data for understanding the safety profile. The aim of this study was to evaluate adverse events of USgFU therapy.<h4>Methods and findings</h4>Clinical data were searched in 2 Chinese databases. Adverse events of USgFU were summarized and compared with those of magnetic resonance-guided HIFU (MRgFU; for uterine, bone or breast tumor) and transrectal ultrasound-guided HIFU (for prostate cancer or benign prostate hyperplasia). USgFU treatment was performed using 7 types of device. Side effects were evaluated in 13262 cases. There were fewer adverse events in benign lesions than in malignant lesions (11.81% vs. 21.65%, p<0.0001). Rates of adverse events greatly varied between the disease types (0-280%, p<0.0001) and between the applied HIFU devices in both malignant (10.58-44.38%, p<0.0001) and benign lesions (1.67-17.57%, p<0.0001). Chronological analysis did not demonstrate a decrease in the rate of adverse events. Based upon evaluable adverse events, incidences in USgFU were consistent with those in MRgFU or transrectal HIFU. Some side effects frequently occurred following transrectal HIFU were not reported in USgFU. Several events including intrahepatic metastasis, intraoperative high fever, and occlusions of the superior mesenteric artery should be of particular concern because they have not been previously noted. The types of adverse events suggested that they were ultrasonic lesions.<h4>Conclusion</h4>The frequency of adverse events depended on the location of the lesion and the type of HIFU device; however, side effects of USgFU were not yet understood. USgFU did not decrease the incidence of adverse events compared with MRgFU.
format	article
author	Tinghe Yu Jun Luo
author_facet	Tinghe Yu Jun Luo
author_sort	Tinghe Yu
title	Adverse events of extracorporeal ultrasound-guided high intensity focused ultrasound therapy.
title_short	Adverse events of extracorporeal ultrasound-guided high intensity focused ultrasound therapy.
title_full	Adverse events of extracorporeal ultrasound-guided high intensity focused ultrasound therapy.
title_fullStr	Adverse events of extracorporeal ultrasound-guided high intensity focused ultrasound therapy.
title_full_unstemmed	Adverse events of extracorporeal ultrasound-guided high intensity focused ultrasound therapy.
title_sort	adverse events of extracorporeal ultrasound-guided high intensity focused ultrasound therapy.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/eeb9cd3e00aa4cdcbc30d497496bfcab
work_keys_str_mv	AT tingheyu adverseeventsofextracorporealultrasoundguidedhighintensityfocusedultrasoundtherapy AT junluo adverseeventsofextracorporealultrasoundguidedhighintensityfocusedultrasoundtherapy
_version_	1718423322734100480

Adverse events of extracorporeal ultrasound-guided high intensity focused ultrasound therapy.

Ejemplares similares