Clinical characteristics of Egyptian male patients with COVID-19 acute respiratory distress syndrome.

<h4>Background</h4>Coronavirus disease 2019 (COVID-19) is a serious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and in severe cases associated with acute respiratory distress syndrome (ARDS).<h4>Objective</h4>To describe the clinical charact...

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Autores principales:	Ahmed S Doghish, Walid F Elkhatib, Essam A Hassan, Ahmed F Elkhateeb, Eman E Mahmoud, Mona I Ahmed, Mahmoud A F Khalil
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/eebc2e9ea2b74452bcc5abeb84a6df7d
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spelling	oai:doaj.org-article:eebc2e9ea2b74452bcc5abeb84a6df7d2021-12-02T20:04:08ZClinical characteristics of Egyptian male patients with COVID-19 acute respiratory distress syndrome.1932-620310.1371/journal.pone.0249346https://doaj.org/article/eebc2e9ea2b74452bcc5abeb84a6df7d2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0249346https://doaj.org/toc/1932-6203<h4>Background</h4>Coronavirus disease 2019 (COVID-19) is a serious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and in severe cases associated with acute respiratory distress syndrome (ARDS).<h4>Objective</h4>To describe the clinical characteristics of patients with ARDS-COVID-19.<h4>Materials and methods</h4>This study involved 197 male Egyptian participants, among them111 COVID-19 patients presented with ARDS, 60 COVID-19 patients presented with non-ARDS, and 26 Non-COVID-19 patients. We reported the analysis results of clinical and laboratory information, including blood routine tests, blood biochemistry parameters [aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine and C-reactive protein (CRP)], thrombotic activity (D-dimer) and serum ferritin and lactate dehydrogenase (LDH).<h4>Results</h4>The levels of hemoglobin, AST, creatinine, monocyte count, monocyte %, RBC count, TLC, and platelet count were not significantly different among the groups. The lymphopenia and increased CRP, ALT, D-dimer, ferritin, and LDH were observed in patients with ARDS-COVID-19.<h4>Conclusion</h4>COVID-19 patients with ARDS presented with lymphopenia, increased thrombotic activity, increased CRP, LDH, and ferritin levels. The results revealed that CRP, D-dimer, LDH levels, and lymphopenia have a significant association with the COVID-19 severity and can be used as biomarkers to predict the disease severity.Ahmed S DoghishWalid F ElkhatibEssam A HassanAhmed F ElkhateebEman E MahmoudMona I AhmedMahmoud A F KhalilPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 4, p e0249346 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ahmed S Doghish Walid F Elkhatib Essam A Hassan Ahmed F Elkhateeb Eman E Mahmoud Mona I Ahmed Mahmoud A F Khalil Clinical characteristics of Egyptian male patients with COVID-19 acute respiratory distress syndrome.
description	<h4>Background</h4>Coronavirus disease 2019 (COVID-19) is a serious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and in severe cases associated with acute respiratory distress syndrome (ARDS).<h4>Objective</h4>To describe the clinical characteristics of patients with ARDS-COVID-19.<h4>Materials and methods</h4>This study involved 197 male Egyptian participants, among them111 COVID-19 patients presented with ARDS, 60 COVID-19 patients presented with non-ARDS, and 26 Non-COVID-19 patients. We reported the analysis results of clinical and laboratory information, including blood routine tests, blood biochemistry parameters [aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine and C-reactive protein (CRP)], thrombotic activity (D-dimer) and serum ferritin and lactate dehydrogenase (LDH).<h4>Results</h4>The levels of hemoglobin, AST, creatinine, monocyte count, monocyte %, RBC count, TLC, and platelet count were not significantly different among the groups. The lymphopenia and increased CRP, ALT, D-dimer, ferritin, and LDH were observed in patients with ARDS-COVID-19.<h4>Conclusion</h4>COVID-19 patients with ARDS presented with lymphopenia, increased thrombotic activity, increased CRP, LDH, and ferritin levels. The results revealed that CRP, D-dimer, LDH levels, and lymphopenia have a significant association with the COVID-19 severity and can be used as biomarkers to predict the disease severity.
format	article
author	Ahmed S Doghish Walid F Elkhatib Essam A Hassan Ahmed F Elkhateeb Eman E Mahmoud Mona I Ahmed Mahmoud A F Khalil
author_facet	Ahmed S Doghish Walid F Elkhatib Essam A Hassan Ahmed F Elkhateeb Eman E Mahmoud Mona I Ahmed Mahmoud A F Khalil
author_sort	Ahmed S Doghish
title	Clinical characteristics of Egyptian male patients with COVID-19 acute respiratory distress syndrome.
title_short	Clinical characteristics of Egyptian male patients with COVID-19 acute respiratory distress syndrome.
title_full	Clinical characteristics of Egyptian male patients with COVID-19 acute respiratory distress syndrome.
title_fullStr	Clinical characteristics of Egyptian male patients with COVID-19 acute respiratory distress syndrome.
title_full_unstemmed	Clinical characteristics of Egyptian male patients with COVID-19 acute respiratory distress syndrome.
title_sort	clinical characteristics of egyptian male patients with covid-19 acute respiratory distress syndrome.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/eebc2e9ea2b74452bcc5abeb84a6df7d
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Clinical characteristics of Egyptian male patients with COVID-19 acute respiratory distress syndrome.

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