Investigation of the Possible Correlation between Idiopathic Parkinson’s Disease and Diabetes Mellitus in Egyptian Patients: A Pilot Study

Objectives. To study the diabetes-Parkinson's disease (PD) linkage. Methods. The investigators recorded the rapid eye movement sleep behavior disorder screening questionnaire (RBDSQ) score for 60 diabetic patients: 30 patients were treated with metformin-inclusive sulfonylurea and 30 patients w...

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Autores principales:	Afnan AwadAllah Elgnainy, Mohammad Ismail Hamed, Wael Osman Mohamed, Nagwa Ali Sabri
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/eec2931688524da2ad065450c5fdfc16
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spelling	oai:doaj.org-article:eec2931688524da2ad065450c5fdfc162021-11-22T01:10:41ZInvestigation of the Possible Correlation between Idiopathic Parkinson’s Disease and Diabetes Mellitus in Egyptian Patients: A Pilot Study2090-186010.1155/2021/2838669https://doaj.org/article/eec2931688524da2ad065450c5fdfc162021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/2838669https://doaj.org/toc/2090-1860Objectives. To study the diabetes-Parkinson's disease (PD) linkage. Methods. The investigators recorded the rapid eye movement sleep behavior disorder screening questionnaire (RBDSQ) score for 60 diabetic patients: 30 patients were treated with metformin-inclusive sulfonylurea and 30 patients were treated with sulphonylurea(s) monotherapy and matched with 30 controls. We evaluated blood glucose kinetics during a 75 g oral glucose tolerance test for (22) nondiabetic parkinsonian patients and (10) controls. The motor complications scores were recorded for all parkinsonian patients using the relevant parts of the Unified Parkinson’s Disease Rating Scale (UPDRS) part IV. Results. Diabetics recorded higher scores of RBDSQ than controls (p<0.001), with no differences related to antidiabetic therapy. In nondiabetic PD patients, after oral glucose, blood glucose was significantly higher at T1 (p<0.001) than controls. Moreover, the total area under the time curve for blood glucose levels was significantly higher in PD compared to controls (281.22 ± 52.25 vs. 245.65 ± 48.63 mg.hr./dL; p=0.013). Higher blood glucose levels were associated with motor abnormalities. Diabetic PD patients recorded higher scores of UPDRS (p<0.001). Conclusion. Diabetes mellitus and Parkinson’s disease are linked, which raises concerns about either of them, probably increasing the risk of the other. This trial is registered with NCT03685357.Afnan AwadAllah ElgnainyMohammad Ismail HamedWael Osman MohamedNagwa Ali SabriHindawi LimitedarticleNeurology. Diseases of the nervous systemRC346-429ENNeurology Research International, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Afnan AwadAllah Elgnainy Mohammad Ismail Hamed Wael Osman Mohamed Nagwa Ali Sabri Investigation of the Possible Correlation between Idiopathic Parkinson’s Disease and Diabetes Mellitus in Egyptian Patients: A Pilot Study
description	Objectives. To study the diabetes-Parkinson's disease (PD) linkage. Methods. The investigators recorded the rapid eye movement sleep behavior disorder screening questionnaire (RBDSQ) score for 60 diabetic patients: 30 patients were treated with metformin-inclusive sulfonylurea and 30 patients were treated with sulphonylurea(s) monotherapy and matched with 30 controls. We evaluated blood glucose kinetics during a 75 g oral glucose tolerance test for (22) nondiabetic parkinsonian patients and (10) controls. The motor complications scores were recorded for all parkinsonian patients using the relevant parts of the Unified Parkinson’s Disease Rating Scale (UPDRS) part IV. Results. Diabetics recorded higher scores of RBDSQ than controls (p<0.001), with no differences related to antidiabetic therapy. In nondiabetic PD patients, after oral glucose, blood glucose was significantly higher at T1 (p<0.001) than controls. Moreover, the total area under the time curve for blood glucose levels was significantly higher in PD compared to controls (281.22 ± 52.25 vs. 245.65 ± 48.63 mg.hr./dL; p=0.013). Higher blood glucose levels were associated with motor abnormalities. Diabetic PD patients recorded higher scores of UPDRS (p<0.001). Conclusion. Diabetes mellitus and Parkinson’s disease are linked, which raises concerns about either of them, probably increasing the risk of the other. This trial is registered with NCT03685357.
format	article
author	Afnan AwadAllah Elgnainy Mohammad Ismail Hamed Wael Osman Mohamed Nagwa Ali Sabri
author_facet	Afnan AwadAllah Elgnainy Mohammad Ismail Hamed Wael Osman Mohamed Nagwa Ali Sabri
author_sort	Afnan AwadAllah Elgnainy
title	Investigation of the Possible Correlation between Idiopathic Parkinson’s Disease and Diabetes Mellitus in Egyptian Patients: A Pilot Study
title_short	Investigation of the Possible Correlation between Idiopathic Parkinson’s Disease and Diabetes Mellitus in Egyptian Patients: A Pilot Study
title_full	Investigation of the Possible Correlation between Idiopathic Parkinson’s Disease and Diabetes Mellitus in Egyptian Patients: A Pilot Study
title_fullStr	Investigation of the Possible Correlation between Idiopathic Parkinson’s Disease and Diabetes Mellitus in Egyptian Patients: A Pilot Study
title_full_unstemmed	Investigation of the Possible Correlation between Idiopathic Parkinson’s Disease and Diabetes Mellitus in Egyptian Patients: A Pilot Study
title_sort	investigation of the possible correlation between idiopathic parkinson’s disease and diabetes mellitus in egyptian patients: a pilot study
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/eec2931688524da2ad065450c5fdfc16
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Investigation of the Possible Correlation between Idiopathic Parkinson’s Disease and Diabetes Mellitus in Egyptian Patients: A Pilot Study

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