Diffusion Tensor Imaging Along the Perivascular Space Index in Different Stages of Parkinson’s Disease

Background: The aim of this study was to evaluate the glymphatic system activity in patients with Parkinson’s disease (PD) using the diffusion tensor image analysis along the perivascular space (DTI-ALPS) methods.Methods: In total, 71 patients with idiopathic PD and 36 age- and sex-matched normal co...

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Autores principales:	Xinxin Ma, Shuhua Li, Chunmei Li, Rui Wang, Min Chen, Haibo Chen, Wen Su
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Parkinson’s disease glymphatic system magnetic resonance imaging diffusion tensor imaging enlarged perivascular spaces Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/eec690106ab3403cb53c41dbe4b63e78
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spelling	oai:doaj.org-article:eec690106ab3403cb53c41dbe4b63e782021-11-15T06:59:55ZDiffusion Tensor Imaging Along the Perivascular Space Index in Different Stages of Parkinson’s Disease1663-436510.3389/fnagi.2021.773951https://doaj.org/article/eec690106ab3403cb53c41dbe4b63e782021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.773951/fullhttps://doaj.org/toc/1663-4365Background: The aim of this study was to evaluate the glymphatic system activity in patients with Parkinson’s disease (PD) using the diffusion tensor image analysis along the perivascular space (DTI-ALPS) methods.Methods: In total, 71 patients with idiopathic PD and 36 age- and sex-matched normal controls (NCs) were involved. Patients with PD were divided into early (n = 35) and late (n = 36) subgroups, based on Hoehn and Yahr (HY) stages. We calculated the diffusivity along the perivascular spaces (ALPS), as well as projection fibers and association fibers separately, to acquire the ALPS index. Enlarged perivascular spaces (EPVS) and periventricular white matter hyperintensities were also rated. Differences in ALPS index between the PD group and NCs and between two PD subgroups and NCs were compared. In addition, a multivariate logistic regression analysis was conducted to investigate the association between ALPS index and clinical variables.Results: Patients with PD revealed lower ALPS index than NCs (p = 0.010). The late PD group exhibited significantly lower ALPS index than NCs (p = 0.006). However, there were no marked differences noticed in ALPS index between NCs and early PD group and between the two PD subgroups. In the early PD group, there was a significantly positive correlation between ALPS index and Mini-Mental State Examination (MMSE) score (β = 0.021, p = 0.029) and a negative correlation between ALPS index and EPVS score (β = −0.050, p = 0.034), after controlling for multiple variables. In the late PD group, ALPS index was inversely associated with age (β = −0.012, p = 0.004).Conclusion: Impairment of the glymphatic system is involved in PD. DTI-ALPS index could be a promising biomarker of glymphatic system in PD.Xinxin MaShuhua LiChunmei LiRui WangMin ChenHaibo ChenWen SuFrontiers Media S.A.articleParkinson’s diseaseglymphatic systemmagnetic resonance imagingdiffusion tensor imagingenlarged perivascular spacesNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Parkinson’s disease glymphatic system magnetic resonance imaging diffusion tensor imaging enlarged perivascular spaces Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Parkinson’s disease glymphatic system magnetic resonance imaging diffusion tensor imaging enlarged perivascular spaces Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Xinxin Ma Shuhua Li Chunmei Li Rui Wang Min Chen Haibo Chen Wen Su Diffusion Tensor Imaging Along the Perivascular Space Index in Different Stages of Parkinson’s Disease
description	Background: The aim of this study was to evaluate the glymphatic system activity in patients with Parkinson’s disease (PD) using the diffusion tensor image analysis along the perivascular space (DTI-ALPS) methods.Methods: In total, 71 patients with idiopathic PD and 36 age- and sex-matched normal controls (NCs) were involved. Patients with PD were divided into early (n = 35) and late (n = 36) subgroups, based on Hoehn and Yahr (HY) stages. We calculated the diffusivity along the perivascular spaces (ALPS), as well as projection fibers and association fibers separately, to acquire the ALPS index. Enlarged perivascular spaces (EPVS) and periventricular white matter hyperintensities were also rated. Differences in ALPS index between the PD group and NCs and between two PD subgroups and NCs were compared. In addition, a multivariate logistic regression analysis was conducted to investigate the association between ALPS index and clinical variables.Results: Patients with PD revealed lower ALPS index than NCs (p = 0.010). The late PD group exhibited significantly lower ALPS index than NCs (p = 0.006). However, there were no marked differences noticed in ALPS index between NCs and early PD group and between the two PD subgroups. In the early PD group, there was a significantly positive correlation between ALPS index and Mini-Mental State Examination (MMSE) score (β = 0.021, p = 0.029) and a negative correlation between ALPS index and EPVS score (β = −0.050, p = 0.034), after controlling for multiple variables. In the late PD group, ALPS index was inversely associated with age (β = −0.012, p = 0.004).Conclusion: Impairment of the glymphatic system is involved in PD. DTI-ALPS index could be a promising biomarker of glymphatic system in PD.
format	article
author	Xinxin Ma Shuhua Li Chunmei Li Rui Wang Min Chen Haibo Chen Wen Su
author_facet	Xinxin Ma Shuhua Li Chunmei Li Rui Wang Min Chen Haibo Chen Wen Su
author_sort	Xinxin Ma
title	Diffusion Tensor Imaging Along the Perivascular Space Index in Different Stages of Parkinson’s Disease
title_short	Diffusion Tensor Imaging Along the Perivascular Space Index in Different Stages of Parkinson’s Disease
title_full	Diffusion Tensor Imaging Along the Perivascular Space Index in Different Stages of Parkinson’s Disease
title_fullStr	Diffusion Tensor Imaging Along the Perivascular Space Index in Different Stages of Parkinson’s Disease
title_full_unstemmed	Diffusion Tensor Imaging Along the Perivascular Space Index in Different Stages of Parkinson’s Disease
title_sort	diffusion tensor imaging along the perivascular space index in different stages of parkinson’s disease
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/eec690106ab3403cb53c41dbe4b63e78
work_keys_str_mv	AT xinxinma diffusiontensorimagingalongtheperivascularspaceindexindifferentstagesofparkinsonsdisease AT shuhuali diffusiontensorimagingalongtheperivascularspaceindexindifferentstagesofparkinsonsdisease AT chunmeili diffusiontensorimagingalongtheperivascularspaceindexindifferentstagesofparkinsonsdisease AT ruiwang diffusiontensorimagingalongtheperivascularspaceindexindifferentstagesofparkinsonsdisease AT minchen diffusiontensorimagingalongtheperivascularspaceindexindifferentstagesofparkinsonsdisease AT haibochen diffusiontensorimagingalongtheperivascularspaceindexindifferentstagesofparkinsonsdisease AT wensu diffusiontensorimagingalongtheperivascularspaceindexindifferentstagesofparkinsonsdisease
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Diffusion Tensor Imaging Along the Perivascular Space Index in Different Stages of Parkinson’s Disease

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