Are the Derived Indexes of Peripheral Whole Blood Cell Counts (NLR, PLR, LMR/MLR) Clinically Significant Prognostic Biomarkers in Multiple Myeloma? A Systematic Review And Meta-Analysis

BackgroundMultiple myeloma (MM) is an incurable malignant plasma cell tumor. Whole blood cell count (WBCC) derived indexes are widely used as a predictive biomarker for various types of solid and hematological malignant tumors. Our study is to evaluate its effectiveness in MM by meta-analysis.Method...

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Autores principales:	Xinwen Zhang, Jialin Duan, Zhenyu Wen, Hao Xiong, Xiaomin Chen, Yang Liu, Kunyu Liao, Chunlan Huang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	multiple myeloma (MM) neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte ratio (PLR) lymphocyte-to-monocyte ratio (LMR) monocyte-to-lymphocyte ratio (MLR) prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/eec690c52bbb4f60b59c45289f1ae5ee
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spelling	oai:doaj.org-article:eec690c52bbb4f60b59c45289f1ae5ee2021-11-30T13:03:01ZAre the Derived Indexes of Peripheral Whole Blood Cell Counts (NLR, PLR, LMR/MLR) Clinically Significant Prognostic Biomarkers in Multiple Myeloma? A Systematic Review And Meta-Analysis2234-943X10.3389/fonc.2021.766672https://doaj.org/article/eec690c52bbb4f60b59c45289f1ae5ee2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.766672/fullhttps://doaj.org/toc/2234-943XBackgroundMultiple myeloma (MM) is an incurable malignant plasma cell tumor. Whole blood cell count (WBCC) derived indexes are widely used as a predictive biomarker for various types of solid and hematological malignant tumors. Our study is to evaluate its effectiveness in MM by meta-analysis.MethodsRelevant literatures were retrieved from PubMed, Embase and Web of Science databases according to PRISMA guideline. All relevant parameters were extracted and combined for statistical analysis.ResultsNineteen studies incorporating 3818 MM patients were eventually included in this meta-analysis. 13 studies evaluated that elevated NLR was significantly associated with poor survival outcomes (OS: HR=2.04, P<0.001; PFS: HR=1.96, P=0.003). Elevated NLR was revealed to correlate with ISS stage (ISS III VS I-II, OR=2.23, P=0.003). A total of 7 studies have shown that elevated LMR predicts a better prognosis in MM patients (OS: HR=0.57, P<0.001; PFS: HR=0.49, P<0.05), and two other studies demonstrated that increased MLR was related to poor OS/PFS (OS: HR=1.58, P<0.05; PFS: HR=1.60, P<0.05). However, in the other 6 studies including 1560 patients, the prognostic value of PLR had not been confirmed (OS: HR=0.89, P>0.05; PFS: HR=0.87, P>0.05).ConclusionsThe indexes NLR and LMR/MLR derived from WBCC were validated to be useful biomarkers to predict the prognosis in MM patients, but the evidence of PLR was insufficient.Xinwen ZhangXinwen ZhangJialin DuanJialin DuanZhenyu WenHao XiongHao XiongXiaomin ChenXiaomin ChenYang LiuYang LiuKunyu LiaoKunyu LiaoChunlan HuangChunlan HuangFrontiers Media S.A.articlemultiple myeloma (MM)neutrophil-to-lymphocyte ratio (NLR)platelet-to-lymphocyte ratio (PLR)lymphocyte-to-monocyte ratio (LMR)monocyte-to-lymphocyte ratio (MLR)prognosisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	multiple myeloma (MM) neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte ratio (PLR) lymphocyte-to-monocyte ratio (LMR) monocyte-to-lymphocyte ratio (MLR) prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	multiple myeloma (MM) neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte ratio (PLR) lymphocyte-to-monocyte ratio (LMR) monocyte-to-lymphocyte ratio (MLR) prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Xinwen Zhang Xinwen Zhang Jialin Duan Jialin Duan Zhenyu Wen Hao Xiong Hao Xiong Xiaomin Chen Xiaomin Chen Yang Liu Yang Liu Kunyu Liao Kunyu Liao Chunlan Huang Chunlan Huang Are the Derived Indexes of Peripheral Whole Blood Cell Counts (NLR, PLR, LMR/MLR) Clinically Significant Prognostic Biomarkers in Multiple Myeloma? A Systematic Review And Meta-Analysis
description	BackgroundMultiple myeloma (MM) is an incurable malignant plasma cell tumor. Whole blood cell count (WBCC) derived indexes are widely used as a predictive biomarker for various types of solid and hematological malignant tumors. Our study is to evaluate its effectiveness in MM by meta-analysis.MethodsRelevant literatures were retrieved from PubMed, Embase and Web of Science databases according to PRISMA guideline. All relevant parameters were extracted and combined for statistical analysis.ResultsNineteen studies incorporating 3818 MM patients were eventually included in this meta-analysis. 13 studies evaluated that elevated NLR was significantly associated with poor survival outcomes (OS: HR=2.04, P<0.001; PFS: HR=1.96, P=0.003). Elevated NLR was revealed to correlate with ISS stage (ISS III VS I-II, OR=2.23, P=0.003). A total of 7 studies have shown that elevated LMR predicts a better prognosis in MM patients (OS: HR=0.57, P<0.001; PFS: HR=0.49, P<0.05), and two other studies demonstrated that increased MLR was related to poor OS/PFS (OS: HR=1.58, P<0.05; PFS: HR=1.60, P<0.05). However, in the other 6 studies including 1560 patients, the prognostic value of PLR had not been confirmed (OS: HR=0.89, P>0.05; PFS: HR=0.87, P>0.05).ConclusionsThe indexes NLR and LMR/MLR derived from WBCC were validated to be useful biomarkers to predict the prognosis in MM patients, but the evidence of PLR was insufficient.
format	article
author	Xinwen Zhang Xinwen Zhang Jialin Duan Jialin Duan Zhenyu Wen Hao Xiong Hao Xiong Xiaomin Chen Xiaomin Chen Yang Liu Yang Liu Kunyu Liao Kunyu Liao Chunlan Huang Chunlan Huang
author_facet	Xinwen Zhang Xinwen Zhang Jialin Duan Jialin Duan Zhenyu Wen Hao Xiong Hao Xiong Xiaomin Chen Xiaomin Chen Yang Liu Yang Liu Kunyu Liao Kunyu Liao Chunlan Huang Chunlan Huang
author_sort	Xinwen Zhang
title	Are the Derived Indexes of Peripheral Whole Blood Cell Counts (NLR, PLR, LMR/MLR) Clinically Significant Prognostic Biomarkers in Multiple Myeloma? A Systematic Review And Meta-Analysis
title_short	Are the Derived Indexes of Peripheral Whole Blood Cell Counts (NLR, PLR, LMR/MLR) Clinically Significant Prognostic Biomarkers in Multiple Myeloma? A Systematic Review And Meta-Analysis
title_full	Are the Derived Indexes of Peripheral Whole Blood Cell Counts (NLR, PLR, LMR/MLR) Clinically Significant Prognostic Biomarkers in Multiple Myeloma? A Systematic Review And Meta-Analysis
title_fullStr	Are the Derived Indexes of Peripheral Whole Blood Cell Counts (NLR, PLR, LMR/MLR) Clinically Significant Prognostic Biomarkers in Multiple Myeloma? A Systematic Review And Meta-Analysis
title_full_unstemmed	Are the Derived Indexes of Peripheral Whole Blood Cell Counts (NLR, PLR, LMR/MLR) Clinically Significant Prognostic Biomarkers in Multiple Myeloma? A Systematic Review And Meta-Analysis
title_sort	are the derived indexes of peripheral whole blood cell counts (nlr, plr, lmr/mlr) clinically significant prognostic biomarkers in multiple myeloma? a systematic review and meta-analysis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/eec690c52bbb4f60b59c45289f1ae5ee
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Are the Derived Indexes of Peripheral Whole Blood Cell Counts (NLR, PLR, LMR/MLR) Clinically Significant Prognostic Biomarkers in Multiple Myeloma? A Systematic Review And Meta-Analysis

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