GABAergic interneurons form transient layer-specific circuits in early postnatal neocortex

GABAergic interneurons form transient layer-specific circuits in early postnatal neocortex

GABAergic interneurons are key components of cortical circuits, yet their early connectivity is unknown. Here the authors show that during early postnatal development,Nkx2-1-derived interneurons engage in layer-specific and dynamic circuits, which are distinct from those in the mature neocortex.

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Autores principales: Paul G. Anastasiades, Andre Marques-Smith, Daniel Lyngholm, Tom Lickiss, Sayda Raffiq, Dennis Kätzel, Gero Miesenböck, Simon J. B. Butt
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/eecafeca6fe24e208afc545e3bdbe8ed
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spelling oai:doaj.org-article:eecafeca6fe24e208afc545e3bdbe8ed2021-12-02T14:38:33ZGABAergic interneurons form transient layer-specific circuits in early postnatal neocortex10.1038/ncomms105842041-1723https://doaj.org/article/eecafeca6fe24e208afc545e3bdbe8ed2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10584https://doaj.org/toc/2041-1723GABAergic interneurons are key components of cortical circuits, yet their early connectivity is unknown. Here the authors show that during early postnatal development,Nkx2-1-derived interneurons engage in layer-specific and dynamic circuits, which are distinct from those in the mature neocortex.Paul G. AnastasiadesAndre Marques-SmithDaniel LyngholmTom LickissSayda RaffiqDennis KätzelGero MiesenböckSimon J. B. ButtNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Paul G. Anastasiades
Andre Marques-Smith
Daniel Lyngholm
Tom Lickiss
Sayda Raffiq
Dennis Kätzel
Gero Miesenböck
Simon J. B. Butt
GABAergic interneurons form transient layer-specific circuits in early postnatal neocortex
description GABAergic interneurons are key components of cortical circuits, yet their early connectivity is unknown. Here the authors show that during early postnatal development,Nkx2-1-derived interneurons engage in layer-specific and dynamic circuits, which are distinct from those in the mature neocortex.
format article
author Paul G. Anastasiades
Andre Marques-Smith
Daniel Lyngholm
Tom Lickiss
Sayda Raffiq
Dennis Kätzel
Gero Miesenböck
Simon J. B. Butt
author_facet Paul G. Anastasiades
Andre Marques-Smith
Daniel Lyngholm
Tom Lickiss
Sayda Raffiq
Dennis Kätzel
Gero Miesenböck
Simon J. B. Butt
author_sort Paul G. Anastasiades
title GABAergic interneurons form transient layer-specific circuits in early postnatal neocortex
title_short GABAergic interneurons form transient layer-specific circuits in early postnatal neocortex
title_full GABAergic interneurons form transient layer-specific circuits in early postnatal neocortex
title_fullStr GABAergic interneurons form transient layer-specific circuits in early postnatal neocortex
title_full_unstemmed GABAergic interneurons form transient layer-specific circuits in early postnatal neocortex
title_sort gabaergic interneurons form transient layer-specific circuits in early postnatal neocortex
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/eecafeca6fe24e208afc545e3bdbe8ed
work_keys_str_mv AT paulganastasiades gabaergicinterneuronsformtransientlayerspecificcircuitsinearlypostnatalneocortex
AT andremarquessmith gabaergicinterneuronsformtransientlayerspecificcircuitsinearlypostnatalneocortex
AT daniellyngholm gabaergicinterneuronsformtransientlayerspecificcircuitsinearlypostnatalneocortex
AT tomlickiss gabaergicinterneuronsformtransientlayerspecificcircuitsinearlypostnatalneocortex
AT saydaraffiq gabaergicinterneuronsformtransientlayerspecificcircuitsinearlypostnatalneocortex
AT denniskatzel gabaergicinterneuronsformtransientlayerspecificcircuitsinearlypostnatalneocortex
AT geromiesenbock gabaergicinterneuronsformtransientlayerspecificcircuitsinearlypostnatalneocortex
AT simonjbbutt gabaergicinterneuronsformtransientlayerspecificcircuitsinearlypostnatalneocortex
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