Early life stress during the neonatal period alters social play and Line1 during the juvenile stage of development

Abstract Early life stress (ELS) has been shown to have a significant impact on typical brain development and the manifestation of psychological disorders through epigenetic modifications that alter gene expression. Line1, a retrotransposon associated with genetic diversity, has been linked with var...

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Autores principales:	Amelia Cuarenta, Stacey L. Kigar, Ian C. Henion, Liza Chang, Vaishali P. Bakshi, Anthony P. Auger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/eecf0c0e195d4483a497e45686335aba
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spelling	oai:doaj.org-article:eecf0c0e195d4483a497e45686335aba2021-12-02T14:27:02ZEarly life stress during the neonatal period alters social play and Line1 during the juvenile stage of development10.1038/s41598-021-82953-32045-2322https://doaj.org/article/eecf0c0e195d4483a497e45686335aba2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82953-3https://doaj.org/toc/2045-2322Abstract Early life stress (ELS) has been shown to have a significant impact on typical brain development and the manifestation of psychological disorders through epigenetic modifications that alter gene expression. Line1, a retrotransposon associated with genetic diversity, has been linked with various psychological disorders that are associated with ELS. Our previous work demonstrated altered Line1 DNA copy number in the neonatal period following stressful experiences; we therefore chose to investigate whether early life stress altered Line1 retrotransposition persists into the juvenile period of development. Our study uses a neonatal predator odor exposure (POE) paradigm to model ELS in rats. We examined Line1 using qPCR to assess Line1 expression levels and DNA copy number in the male and female juvenile amygdala, hippocampus and prefrontal cortex—areas chosen for their association with affective disorders and stress. We report a sex difference in Line1 levels within the juvenile amygdala. We also find that ELS significantly increases Line1 DNA copy number within the juvenile amygdala which correlates with reduced juvenile social play levels, suggesting the possibility that Line1 may influence juvenile social development.Amelia CuarentaStacey L. KigarIan C. HenionLiza ChangVaishali P. BakshiAnthony P. AugerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Amelia Cuarenta Stacey L. Kigar Ian C. Henion Liza Chang Vaishali P. Bakshi Anthony P. Auger Early life stress during the neonatal period alters social play and Line1 during the juvenile stage of development
description	Abstract Early life stress (ELS) has been shown to have a significant impact on typical brain development and the manifestation of psychological disorders through epigenetic modifications that alter gene expression. Line1, a retrotransposon associated with genetic diversity, has been linked with various psychological disorders that are associated with ELS. Our previous work demonstrated altered Line1 DNA copy number in the neonatal period following stressful experiences; we therefore chose to investigate whether early life stress altered Line1 retrotransposition persists into the juvenile period of development. Our study uses a neonatal predator odor exposure (POE) paradigm to model ELS in rats. We examined Line1 using qPCR to assess Line1 expression levels and DNA copy number in the male and female juvenile amygdala, hippocampus and prefrontal cortex—areas chosen for their association with affective disorders and stress. We report a sex difference in Line1 levels within the juvenile amygdala. We also find that ELS significantly increases Line1 DNA copy number within the juvenile amygdala which correlates with reduced juvenile social play levels, suggesting the possibility that Line1 may influence juvenile social development.
format	article
author	Amelia Cuarenta Stacey L. Kigar Ian C. Henion Liza Chang Vaishali P. Bakshi Anthony P. Auger
author_facet	Amelia Cuarenta Stacey L. Kigar Ian C. Henion Liza Chang Vaishali P. Bakshi Anthony P. Auger
author_sort	Amelia Cuarenta
title	Early life stress during the neonatal period alters social play and Line1 during the juvenile stage of development
title_short	Early life stress during the neonatal period alters social play and Line1 during the juvenile stage of development
title_full	Early life stress during the neonatal period alters social play and Line1 during the juvenile stage of development
title_fullStr	Early life stress during the neonatal period alters social play and Line1 during the juvenile stage of development
title_full_unstemmed	Early life stress during the neonatal period alters social play and Line1 during the juvenile stage of development
title_sort	early life stress during the neonatal period alters social play and line1 during the juvenile stage of development
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/eecf0c0e195d4483a497e45686335aba
work_keys_str_mv	AT ameliacuarenta earlylifestressduringtheneonatalperiodalterssocialplayandline1duringthejuvenilestageofdevelopment AT staceylkigar earlylifestressduringtheneonatalperiodalterssocialplayandline1duringthejuvenilestageofdevelopment AT ianchenion earlylifestressduringtheneonatalperiodalterssocialplayandline1duringthejuvenilestageofdevelopment AT lizachang earlylifestressduringtheneonatalperiodalterssocialplayandline1duringthejuvenilestageofdevelopment AT vaishalipbakshi earlylifestressduringtheneonatalperiodalterssocialplayandline1duringthejuvenilestageofdevelopment AT anthonypauger earlylifestressduringtheneonatalperiodalterssocialplayandline1duringthejuvenilestageofdevelopment
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Early life stress during the neonatal period alters social play and Line1 during the juvenile stage of development

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