Influence of Telomere Length on the Achievement of Deep Molecular Response With Imatinib in Chronic Myeloid Leukemia Patients
Tyrosine kinase inhibitors have dramatically changed the outcome of chronic myeloid leukemia (CML), and nowadays, one of the main treatment goals is the achievement of deep molecular responses (DMRs), which can eventually lead to therapy discontinuation approaches. Few biological factors at diagnosi...
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Wolters Kluwer
2021
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oai:doaj.org-article:eed0d7528f1d408cb71f85ec9f0948612021-11-25T07:58:36ZInfluence of Telomere Length on the Achievement of Deep Molecular Response With Imatinib in Chronic Myeloid Leukemia Patients2572-924110.1097/HS9.0000000000000657https://doaj.org/article/eed0d7528f1d408cb71f85ec9f0948612021-12-01T00:00:00Zhttp://journals.lww.com/10.1097/HS9.0000000000000657https://doaj.org/toc/2572-9241Tyrosine kinase inhibitors have dramatically changed the outcome of chronic myeloid leukemia (CML), and nowadays, one of the main treatment goals is the achievement of deep molecular responses (DMRs), which can eventually lead to therapy discontinuation approaches. Few biological factors at diagnosis have been associated with this level of response. Telomere length (TL) in peripheral blood cells of patients with CML has been related to disease stage, response to therapy and disease progression, but little is known about its role on DMR. In this study, we analyzed if age-adjusted TL (referred as “delta-TL”) at diagnosis of chronic phase (CP)-CML might correlate with the achievement of DMR under first-line imatinib treatment. TL from 96 CP-CML patients had been retrospectively analyzed at diagnosis by monochrome multiplex quantitative PCR. We observed that patients with longer age-adjusted telomeres at diagnosis had higher probabilities to achieve DMR with imatinib than those with shortened telomeres (P = 0.035 when delta-TL was studied as a continuous variable and P = 0.047 when categorized by the median). Moreover, patients carrying long telomeres also achieved major molecular response significantly earlier (P = 0.012). This study provides proof of concept that TL has a role in CML biology and when measured at diagnosis of CP-CML could help to identify patients likely to achieve DMR to first-line imatinib treatment.Natalia EstradaBlanca XicoyFabian BeierOlga GarciaCristian MoralesConcepción BoquéMiguel SagüésMónica S. Ventura FerreiraRolando VallansotSílvia MarcéMarta CabezónTim H. BrümmendorfLurdes ZamoraWolters KluwerarticleDiseases of the blood and blood-forming organsRC633-647.5ENHemaSphere, Vol 5, Iss 12, p e657 (2021) |
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Diseases of the blood and blood-forming organs RC633-647.5 |
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Diseases of the blood and blood-forming organs RC633-647.5 Natalia Estrada Blanca Xicoy Fabian Beier Olga Garcia Cristian Morales Concepción Boqué Miguel Sagüés Mónica S. Ventura Ferreira Rolando Vallansot Sílvia Marcé Marta Cabezón Tim H. Brümmendorf Lurdes Zamora Influence of Telomere Length on the Achievement of Deep Molecular Response With Imatinib in Chronic Myeloid Leukemia Patients |
| description |
Tyrosine kinase inhibitors have dramatically changed the outcome of chronic myeloid leukemia (CML), and nowadays, one of the main treatment goals is the achievement of deep molecular responses (DMRs), which can eventually lead to therapy discontinuation approaches. Few biological factors at diagnosis have been associated with this level of response. Telomere length (TL) in peripheral blood cells of patients with CML has been related to disease stage, response to therapy and disease progression, but little is known about its role on DMR. In this study, we analyzed if age-adjusted TL (referred as “delta-TL”) at diagnosis of chronic phase (CP)-CML might correlate with the achievement of DMR under first-line imatinib treatment. TL from 96 CP-CML patients had been retrospectively analyzed at diagnosis by monochrome multiplex quantitative PCR. We observed that patients with longer age-adjusted telomeres at diagnosis had higher probabilities to achieve DMR with imatinib than those with shortened telomeres (P = 0.035 when delta-TL was studied as a continuous variable and P = 0.047 when categorized by the median). Moreover, patients carrying long telomeres also achieved major molecular response significantly earlier (P = 0.012). This study provides proof of concept that TL has a role in CML biology and when measured at diagnosis of CP-CML could help to identify patients likely to achieve DMR to first-line imatinib treatment. |
| format |
article |
| author |
Natalia Estrada Blanca Xicoy Fabian Beier Olga Garcia Cristian Morales Concepción Boqué Miguel Sagüés Mónica S. Ventura Ferreira Rolando Vallansot Sílvia Marcé Marta Cabezón Tim H. Brümmendorf Lurdes Zamora |
| author_facet |
Natalia Estrada Blanca Xicoy Fabian Beier Olga Garcia Cristian Morales Concepción Boqué Miguel Sagüés Mónica S. Ventura Ferreira Rolando Vallansot Sílvia Marcé Marta Cabezón Tim H. Brümmendorf Lurdes Zamora |
| author_sort |
Natalia Estrada |
| title |
Influence of Telomere Length on the Achievement of Deep Molecular Response With Imatinib in Chronic Myeloid Leukemia Patients |
| title_short |
Influence of Telomere Length on the Achievement of Deep Molecular Response With Imatinib in Chronic Myeloid Leukemia Patients |
| title_full |
Influence of Telomere Length on the Achievement of Deep Molecular Response With Imatinib in Chronic Myeloid Leukemia Patients |
| title_fullStr |
Influence of Telomere Length on the Achievement of Deep Molecular Response With Imatinib in Chronic Myeloid Leukemia Patients |
| title_full_unstemmed |
Influence of Telomere Length on the Achievement of Deep Molecular Response With Imatinib in Chronic Myeloid Leukemia Patients |
| title_sort |
influence of telomere length on the achievement of deep molecular response with imatinib in chronic myeloid leukemia patients |
| publisher |
Wolters Kluwer |
| publishDate |
2021 |
| url |
https://doaj.org/article/eed0d7528f1d408cb71f85ec9f094861 |
| work_keys_str_mv |
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