Diagnostic usefulness of the spot urine sodium/potassium ratio in cirrhotic patients with ascites.
<h4>Background and aims</h4>The low-salt diet is considered important for control of ascites in cirrhotic patients. To validate whether the spot urine sodium (Na)/potassium (K) ratio could replace 24-h urine Na (uNa) excretion in assessing low-salt diet compliance.<h4>Methods</h...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/eed3916e21284e79a1348de8a06ed651 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:eed3916e21284e79a1348de8a06ed651 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:eed3916e21284e79a1348de8a06ed6512021-12-02T20:10:05ZDiagnostic usefulness of the spot urine sodium/potassium ratio in cirrhotic patients with ascites.1932-620310.1371/journal.pone.0253886https://doaj.org/article/eed3916e21284e79a1348de8a06ed6512021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253886https://doaj.org/toc/1932-6203<h4>Background and aims</h4>The low-salt diet is considered important for control of ascites in cirrhotic patients. To validate whether the spot urine sodium (Na)/potassium (K) ratio could replace 24-h urine Na (uNa) excretion in assessing low-salt diet compliance.<h4>Methods</h4>We prospectively studied 175 patients. 24-h urine collection and spot urine collection were performed. Subsequently, 24-h uNa, urine creatinine (uCr), and spot urine Na and K were assessed. A complete urine collection was confirmed based on 24-h uCr excretion levels of 15mg/kg/day for men and 10mg/kg/day for women. The area under the receiver operating characteristic (AUROC) curve analysis was performed to evaluate the feasibility of spot urine Na/K ratio in predicting 24-h uNa greater than 78mmol/day.<h4>Results</h4>Out of 175 patients, 24-h urine samples were completely collected in 57 patients only. Moreover, urine samples were not completely collected in 118 patients because their 24-h uCr excretion level was less than the established criteria. In complete urine collection group, AUROC curve for spot urine Na/K ratio in predicting 24-h uNa greater than 78mmol/day was 0.874±0.051 (P<0.001). In the incomplete urine collection group, the AUROC was 0.832±0.039 (P<0.001). In complete urine collection group, the classical cutoff value greater than 1.0 of spot urine Na/K ratio showed 90.9% sensitivity and 56.0% specificity.<h4>Conclusions</h4>The spot urine Na/K ratio reflects 24-h uNa, but the AUROC value obtained in this study is lower than that of a previous study. Considered the large number of patients with incomplete urine collection, validating 24-h complete urine collection criteria is necessary.Jin Wook LeeJae Seok HwangWoo Jin ChungHeon Ju LeeJung Gil ParkChang Hyeong LeeByung Seok KimJeong Eun SongYoung Oh KweonWon Young TakSoo Young ParkSe Young JangJeong Ill SuhByoung Kuk JangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253886 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Jin Wook Lee Jae Seok Hwang Woo Jin Chung Heon Ju Lee Jung Gil Park Chang Hyeong Lee Byung Seok Kim Jeong Eun Song Young Oh Kweon Won Young Tak Soo Young Park Se Young Jang Jeong Ill Suh Byoung Kuk Jang Diagnostic usefulness of the spot urine sodium/potassium ratio in cirrhotic patients with ascites. |
| description |
<h4>Background and aims</h4>The low-salt diet is considered important for control of ascites in cirrhotic patients. To validate whether the spot urine sodium (Na)/potassium (K) ratio could replace 24-h urine Na (uNa) excretion in assessing low-salt diet compliance.<h4>Methods</h4>We prospectively studied 175 patients. 24-h urine collection and spot urine collection were performed. Subsequently, 24-h uNa, urine creatinine (uCr), and spot urine Na and K were assessed. A complete urine collection was confirmed based on 24-h uCr excretion levels of 15mg/kg/day for men and 10mg/kg/day for women. The area under the receiver operating characteristic (AUROC) curve analysis was performed to evaluate the feasibility of spot urine Na/K ratio in predicting 24-h uNa greater than 78mmol/day.<h4>Results</h4>Out of 175 patients, 24-h urine samples were completely collected in 57 patients only. Moreover, urine samples were not completely collected in 118 patients because their 24-h uCr excretion level was less than the established criteria. In complete urine collection group, AUROC curve for spot urine Na/K ratio in predicting 24-h uNa greater than 78mmol/day was 0.874±0.051 (P<0.001). In the incomplete urine collection group, the AUROC was 0.832±0.039 (P<0.001). In complete urine collection group, the classical cutoff value greater than 1.0 of spot urine Na/K ratio showed 90.9% sensitivity and 56.0% specificity.<h4>Conclusions</h4>The spot urine Na/K ratio reflects 24-h uNa, but the AUROC value obtained in this study is lower than that of a previous study. Considered the large number of patients with incomplete urine collection, validating 24-h complete urine collection criteria is necessary. |
| format |
article |
| author |
Jin Wook Lee Jae Seok Hwang Woo Jin Chung Heon Ju Lee Jung Gil Park Chang Hyeong Lee Byung Seok Kim Jeong Eun Song Young Oh Kweon Won Young Tak Soo Young Park Se Young Jang Jeong Ill Suh Byoung Kuk Jang |
| author_facet |
Jin Wook Lee Jae Seok Hwang Woo Jin Chung Heon Ju Lee Jung Gil Park Chang Hyeong Lee Byung Seok Kim Jeong Eun Song Young Oh Kweon Won Young Tak Soo Young Park Se Young Jang Jeong Ill Suh Byoung Kuk Jang |
| author_sort |
Jin Wook Lee |
| title |
Diagnostic usefulness of the spot urine sodium/potassium ratio in cirrhotic patients with ascites. |
| title_short |
Diagnostic usefulness of the spot urine sodium/potassium ratio in cirrhotic patients with ascites. |
| title_full |
Diagnostic usefulness of the spot urine sodium/potassium ratio in cirrhotic patients with ascites. |
| title_fullStr |
Diagnostic usefulness of the spot urine sodium/potassium ratio in cirrhotic patients with ascites. |
| title_full_unstemmed |
Diagnostic usefulness of the spot urine sodium/potassium ratio in cirrhotic patients with ascites. |
| title_sort |
diagnostic usefulness of the spot urine sodium/potassium ratio in cirrhotic patients with ascites. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2021 |
| url |
https://doaj.org/article/eed3916e21284e79a1348de8a06ed651 |
| work_keys_str_mv |
AT jinwooklee diagnosticusefulnessofthespoturinesodiumpotassiumratioincirrhoticpatientswithascites AT jaeseokhwang diagnosticusefulnessofthespoturinesodiumpotassiumratioincirrhoticpatientswithascites AT woojinchung diagnosticusefulnessofthespoturinesodiumpotassiumratioincirrhoticpatientswithascites AT heonjulee diagnosticusefulnessofthespoturinesodiumpotassiumratioincirrhoticpatientswithascites AT junggilpark diagnosticusefulnessofthespoturinesodiumpotassiumratioincirrhoticpatientswithascites AT changhyeonglee diagnosticusefulnessofthespoturinesodiumpotassiumratioincirrhoticpatientswithascites AT byungseokkim diagnosticusefulnessofthespoturinesodiumpotassiumratioincirrhoticpatientswithascites AT jeongeunsong diagnosticusefulnessofthespoturinesodiumpotassiumratioincirrhoticpatientswithascites AT youngohkweon diagnosticusefulnessofthespoturinesodiumpotassiumratioincirrhoticpatientswithascites AT wonyoungtak diagnosticusefulnessofthespoturinesodiumpotassiumratioincirrhoticpatientswithascites AT sooyoungpark diagnosticusefulnessofthespoturinesodiumpotassiumratioincirrhoticpatientswithascites AT seyoungjang diagnosticusefulnessofthespoturinesodiumpotassiumratioincirrhoticpatientswithascites AT jeongillsuh diagnosticusefulnessofthespoturinesodiumpotassiumratioincirrhoticpatientswithascites AT byoungkukjang diagnosticusefulnessofthespoturinesodiumpotassiumratioincirrhoticpatientswithascites |
| _version_ |
1718375036260188160 |