Ethanolamine: A Signal to Commence a Host-Associated Lifestyle?

ABSTRACT Ethanolamine (EA) is a compound prevalent in the gastrointestinal (GI) environment. The ability to catabolize this compound has been associated with important GI pathogens, including enterohemorrhagic Escherichia coli O157:H7 (EHEC). It has been hypothesized that the ability of EHEC to util...

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Autor principal: Danielle A. Garsin
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Publicado: American Society for Microbiology 2012
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spelling oai:doaj.org-article:eed40efd1b05473eb561ce5e535ba60c2021-11-15T15:39:10ZEthanolamine: A Signal to Commence a Host-Associated Lifestyle?10.1128/mBio.00172-122150-7511https://doaj.org/article/eed40efd1b05473eb561ce5e535ba60c2012-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00172-12https://doaj.org/toc/2150-7511ABSTRACT Ethanolamine (EA) is a compound prevalent in the gastrointestinal (GI) environment. The ability to catabolize this compound has been associated with important GI pathogens, including enterohemorrhagic Escherichia coli O157:H7 (EHEC). It has been hypothesized that the ability of EHEC to utilize EA as a source of nitrogen provides EHEC with an important competitive advantage in the gut. However, new work by Kendall et al. (mBio 3:e00050-12, 2012) suggests that the role of EA in EHEC pathogenesis may be more fundamental; EA appears to be a signal for EHEC to commence its virulence program. In this commentary, I review the previously described connections of EA to bacterial pathogenesis in the GI tract, highlight the important findings of this new study, and note areas where further research is needed to fully comprehend the connection of EA utilization to bacterial pathogenesis.Danielle A. GarsinAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 3, Iss 4 (2012)
institution DOAJ
collection DOAJ
language EN
topic Microbiology
QR1-502
spellingShingle Microbiology
QR1-502
Danielle A. Garsin
Ethanolamine: A Signal to Commence a Host-Associated Lifestyle?
description ABSTRACT Ethanolamine (EA) is a compound prevalent in the gastrointestinal (GI) environment. The ability to catabolize this compound has been associated with important GI pathogens, including enterohemorrhagic Escherichia coli O157:H7 (EHEC). It has been hypothesized that the ability of EHEC to utilize EA as a source of nitrogen provides EHEC with an important competitive advantage in the gut. However, new work by Kendall et al. (mBio 3:e00050-12, 2012) suggests that the role of EA in EHEC pathogenesis may be more fundamental; EA appears to be a signal for EHEC to commence its virulence program. In this commentary, I review the previously described connections of EA to bacterial pathogenesis in the GI tract, highlight the important findings of this new study, and note areas where further research is needed to fully comprehend the connection of EA utilization to bacterial pathogenesis.
format article
author Danielle A. Garsin
author_facet Danielle A. Garsin
author_sort Danielle A. Garsin
title Ethanolamine: A Signal to Commence a Host-Associated Lifestyle?
title_short Ethanolamine: A Signal to Commence a Host-Associated Lifestyle?
title_full Ethanolamine: A Signal to Commence a Host-Associated Lifestyle?
title_fullStr Ethanolamine: A Signal to Commence a Host-Associated Lifestyle?
title_full_unstemmed Ethanolamine: A Signal to Commence a Host-Associated Lifestyle?
title_sort ethanolamine: a signal to commence a host-associated lifestyle?
publisher American Society for Microbiology
publishDate 2012
url https://doaj.org/article/eed40efd1b05473eb561ce5e535ba60c
work_keys_str_mv AT danielleagarsin ethanolamineasignaltocommenceahostassociatedlifestyle
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