Fabrication of antibiotic-loaded dissolvable calcium sulfate beads: an in vitro mixing lab utilizing various antibiotic mixing formulas

Chronic periprosthetic joint infection (PJI) is a devastating complication that requires an aggressive eradication protocol. Local antimicrobial delivery via dissolvable calcium sulfate (CaSO4) using small-size...

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Autores principales:	E. J. McPherson, M. V. Dipane, M. Chowdhry, A. J. Wassef
Formato:	article
Lenguaje:	EN
Publicado:	Copernicus Publications 2021
Materias:	Orthopedic surgery RD701-811
Acceso en línea:	https://doaj.org/article/eed5099131924127bab9db90fc420a6b
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spelling	oai:doaj.org-article:eed5099131924127bab9db90fc420a6b2021-11-10T06:55:42ZFabrication of antibiotic-loaded dissolvable calcium sulfate beads: an in vitro mixing lab utilizing various antibiotic mixing formulas10.5194/jbji-6-405-20212206-3552https://doaj.org/article/eed5099131924127bab9db90fc420a6b2021-11-01T00:00:00Zhttps://jbji.copernicus.org/articles/6/405/2021/jbji-6-405-2021.pdfhttps://doaj.org/toc/2206-3552<p>Chronic periprosthetic joint infection (PJI) is a devastating complication that requires an aggressive eradication protocol. Local antimicrobial delivery via dissolvable calcium sulfate (CaSO<span class="inline-formula"><sub>4</sub></span>) using small-sized beads (3–8 mm) has been utilized as an adjunctive treatment combined with implant exchange, radical debridement, and antimicrobial loaded acrylic spacers. The non-exothermic setting of CaSO<span class="inline-formula"><sub>4</sub></span> theoretically allows for any antimicrobial agent to be used, so long as mixing methods provide a consistent fabrication within a reasonable set time. This study performed the first in vitro mixing study, in which various antimicrobial agents, used singularly and in combination, were mixed with a synthetic CaSO<span class="inline-formula"><sub>4</sub></span> product to observe and document their interactions. The study was performed in a simulated operating room environment. We report a standard mix formula with set times, testing 22 different antimicrobial agents, combinations, and doses. For some antimicrobials and combinations, set times using the standard formula were either too fast or exceedingly slow. For these 14 antimicrobial agents and combinations, we were able to arrive at individualized mixing methods. We present all mixing formulas and set times. In all, we were able to establish mixing methods that incorporate all antimicrobial agents and combinations that we have seen utilized via surgeon-directed use.</p>E. J. McPhersonM. V. DipaneM. ChowdhryA. J. WassefCopernicus PublicationsarticleOrthopedic surgeryRD701-811ENJournal of Bone and Joint Infection, Vol 6, Pp 405-412 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Orthopedic surgery RD701-811
spellingShingle	Orthopedic surgery RD701-811 E. J. McPherson M. V. Dipane M. Chowdhry A. J. Wassef Fabrication of antibiotic-loaded dissolvable calcium sulfate beads: an in vitro mixing lab utilizing various antibiotic mixing formulas
description	<p>Chronic periprosthetic joint infection (PJI) is a devastating complication that requires an aggressive eradication protocol. Local antimicrobial delivery via dissolvable calcium sulfate (CaSO<span class="inline-formula"><sub>4</sub></span>) using small-sized beads (3–8 mm) has been utilized as an adjunctive treatment combined with implant exchange, radical debridement, and antimicrobial loaded acrylic spacers. The non-exothermic setting of CaSO<span class="inline-formula"><sub>4</sub></span> theoretically allows for any antimicrobial agent to be used, so long as mixing methods provide a consistent fabrication within a reasonable set time. This study performed the first in vitro mixing study, in which various antimicrobial agents, used singularly and in combination, were mixed with a synthetic CaSO<span class="inline-formula"><sub>4</sub></span> product to observe and document their interactions. The study was performed in a simulated operating room environment. We report a standard mix formula with set times, testing 22 different antimicrobial agents, combinations, and doses. For some antimicrobials and combinations, set times using the standard formula were either too fast or exceedingly slow. For these 14 antimicrobial agents and combinations, we were able to arrive at individualized mixing methods. We present all mixing formulas and set times. In all, we were able to establish mixing methods that incorporate all antimicrobial agents and combinations that we have seen utilized via surgeon-directed use.</p>
format	article
author	E. J. McPherson M. V. Dipane M. Chowdhry A. J. Wassef
author_facet	E. J. McPherson M. V. Dipane M. Chowdhry A. J. Wassef
author_sort	E. J. McPherson
title	Fabrication of antibiotic-loaded dissolvable calcium sulfate beads: an in vitro mixing lab utilizing various antibiotic mixing formulas
title_short	Fabrication of antibiotic-loaded dissolvable calcium sulfate beads: an in vitro mixing lab utilizing various antibiotic mixing formulas
title_full	Fabrication of antibiotic-loaded dissolvable calcium sulfate beads: an in vitro mixing lab utilizing various antibiotic mixing formulas
title_fullStr	Fabrication of antibiotic-loaded dissolvable calcium sulfate beads: an in vitro mixing lab utilizing various antibiotic mixing formulas
title_full_unstemmed	Fabrication of antibiotic-loaded dissolvable calcium sulfate beads: an in vitro mixing lab utilizing various antibiotic mixing formulas
title_sort	fabrication of antibiotic-loaded dissolvable calcium sulfate beads: an in vitro mixing lab utilizing various antibiotic mixing formulas
publisher	Copernicus Publications
publishDate	2021
url	https://doaj.org/article/eed5099131924127bab9db90fc420a6b
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Fabrication of antibiotic-loaded dissolvable calcium sulfate beads: an in vitro mixing lab utilizing various antibiotic mixing formulas

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