Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease

ARPC1B is a component of the actin-related protein 2/3 complex (Arp2/3), which is required for actin filament branching. Kahret al. show that ARPC1B deficiency in humans is associated with severe multisystem disease that includes platelet abnormalities, eosinophilia, eczema and other indicators of i...

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Autores principales:	Walter H. A. Kahr, Fred G. Pluthero, Abdul Elkadri, Neil Warner, Marko Drobac, Chang Hua Chen, Richard W. Lo, Ling Li, Ren Li, Qi Li, Cornelia Thoeni, Jie Pan, Gabriella Leung, Irene Lara-Corrales, Ryan Murchie, Ernest Cutz, Ronald M. Laxer, Julia Upton, Chaim M. Roifman, Rae S. M. Yeung, John H Brumell, Aleixo M Muise
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eed6b90418cc417ea55ca5834ef97650
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spelling	oai:doaj.org-article:eed6b90418cc417ea55ca5834ef976502021-12-02T15:38:55ZLoss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease10.1038/ncomms148162041-1723https://doaj.org/article/eed6b90418cc417ea55ca5834ef976502017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14816https://doaj.org/toc/2041-1723ARPC1B is a component of the actin-related protein 2/3 complex (Arp2/3), which is required for actin filament branching. Kahret al. show that ARPC1B deficiency in humans is associated with severe multisystem disease that includes platelet abnormalities, eosinophilia, eczema and other indicators of immune disease.Walter H. A. KahrFred G. PlutheroAbdul ElkadriNeil WarnerMarko DrobacChang Hua ChenRichard W. LoLing LiRen LiQi LiCornelia ThoeniJie PanGabriella LeungIrene Lara-CorralesRyan MurchieErnest CutzRonald M. LaxerJulia UptonChaim M. RoifmanRae S. M. YeungJohn H BrumellAleixo M MuiseNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Walter H. A. Kahr Fred G. Pluthero Abdul Elkadri Neil Warner Marko Drobac Chang Hua Chen Richard W. Lo Ling Li Ren Li Qi Li Cornelia Thoeni Jie Pan Gabriella Leung Irene Lara-Corrales Ryan Murchie Ernest Cutz Ronald M. Laxer Julia Upton Chaim M. Roifman Rae S. M. Yeung John H Brumell Aleixo M Muise Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease
description	ARPC1B is a component of the actin-related protein 2/3 complex (Arp2/3), which is required for actin filament branching. Kahret al. show that ARPC1B deficiency in humans is associated with severe multisystem disease that includes platelet abnormalities, eosinophilia, eczema and other indicators of immune disease.
format	article
author	Walter H. A. Kahr Fred G. Pluthero Abdul Elkadri Neil Warner Marko Drobac Chang Hua Chen Richard W. Lo Ling Li Ren Li Qi Li Cornelia Thoeni Jie Pan Gabriella Leung Irene Lara-Corrales Ryan Murchie Ernest Cutz Ronald M. Laxer Julia Upton Chaim M. Roifman Rae S. M. Yeung John H Brumell Aleixo M Muise
author_facet	Walter H. A. Kahr Fred G. Pluthero Abdul Elkadri Neil Warner Marko Drobac Chang Hua Chen Richard W. Lo Ling Li Ren Li Qi Li Cornelia Thoeni Jie Pan Gabriella Leung Irene Lara-Corrales Ryan Murchie Ernest Cutz Ronald M. Laxer Julia Upton Chaim M. Roifman Rae S. M. Yeung John H Brumell Aleixo M Muise
author_sort	Walter H. A. Kahr
title	Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease
title_short	Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease
title_full	Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease
title_fullStr	Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease
title_full_unstemmed	Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease
title_sort	loss of the arp2/3 complex component arpc1b causes platelet abnormalities and predisposes to inflammatory disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/eed6b90418cc417ea55ca5834ef97650
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Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease

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