Keap1âNrf2 pathway: A promising target towards lung cancer prevention and therapeutics

Objectives: Drugs for targeted therapy have become a new strategy of adjuvant therapy for treatment of lung cancer. The Keap1 (kelch-like ECH-associated protein 1)âNrf2 (nuclear factor erythroid 2-related factor 2) pathway is recognized to be critical in regulating genes related to the cellular prot...

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Autores principales:	Ying-Hui Tong, Bo Zhang, Yun Fan, Neng-Ming Lin
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/eeda3216f74f4415abf1daac22219248
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spelling	oai:doaj.org-article:eeda3216f74f4415abf1daac222192482021-12-02T13:28:50ZKeap1âNrf2 pathway: A promising target towards lung cancer prevention and therapeutics2095-882X10.1016/j.cdtm.2015.09.002https://doaj.org/article/eeda3216f74f4415abf1daac222192482015-09-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X15000535https://doaj.org/toc/2095-882XObjectives: Drugs for targeted therapy have become a new strategy of adjuvant therapy for treatment of lung cancer. The Keap1 (kelch-like ECH-associated protein 1)âNrf2 (nuclear factor erythroid 2-related factor 2) pathway is recognized to be critical in regulating genes related to the cellular protective response and protecting cells from oxidative damages and toxic insult. Methods: Pubmed, Embase, OVID, and the Cochrane Library databases were searched from the beginning of each database without any limitations to the date of publication. Search terms were âNrf2â or âKeap1â and âLung cancerâ. Results: The upregulation of Nrf2 had been closely related to tumor protection and drug resistance. The aberrant state of Keap1 or Nrf2 that were frequently found in lung cancer conferred a poor prognosis. Nrf2 could prevent cells from undergoing oncogenesis as a tumor suppressor, while it could also promote cancer progression and resistance to chemotherapeutic drugs as an oncogene, depending on the different stages of tumor progression. Target Nrf2 signaling by specific chemicals showed it could prevent tumor growth or combat chemoresistance. Conclusions: Increasing evidence has demonstrated the dual roles of the Keap1âNrf2 pathway in tumor initiation and progression. In this paper, we provide a comprehensive overview of the potency of the Keap1âNrf2 pathway as an antitumor target, and the current status of Nrf2 activators or inhibitors for therapeutic approaches. Further studies are required to clarify the role of Nrf2 in lung cancer at different tumor stages, in order to maximize the efficacy of Keap1âNrf2 targeting agents. Keywords: Cancer prevention, Keap1, Lung cancer, Nrf2Ying-Hui TongBo ZhangYun FanNeng-Ming LinKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 1, Iss 3, Pp 175-186 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Ying-Hui Tong Bo Zhang Yun Fan Neng-Ming Lin Keap1âNrf2 pathway: A promising target towards lung cancer prevention and therapeutics
description	Objectives: Drugs for targeted therapy have become a new strategy of adjuvant therapy for treatment of lung cancer. The Keap1 (kelch-like ECH-associated protein 1)âNrf2 (nuclear factor erythroid 2-related factor 2) pathway is recognized to be critical in regulating genes related to the cellular protective response and protecting cells from oxidative damages and toxic insult. Methods: Pubmed, Embase, OVID, and the Cochrane Library databases were searched from the beginning of each database without any limitations to the date of publication. Search terms were âNrf2â or âKeap1â and âLung cancerâ. Results: The upregulation of Nrf2 had been closely related to tumor protection and drug resistance. The aberrant state of Keap1 or Nrf2 that were frequently found in lung cancer conferred a poor prognosis. Nrf2 could prevent cells from undergoing oncogenesis as a tumor suppressor, while it could also promote cancer progression and resistance to chemotherapeutic drugs as an oncogene, depending on the different stages of tumor progression. Target Nrf2 signaling by specific chemicals showed it could prevent tumor growth or combat chemoresistance. Conclusions: Increasing evidence has demonstrated the dual roles of the Keap1âNrf2 pathway in tumor initiation and progression. In this paper, we provide a comprehensive overview of the potency of the Keap1âNrf2 pathway as an antitumor target, and the current status of Nrf2 activators or inhibitors for therapeutic approaches. Further studies are required to clarify the role of Nrf2 in lung cancer at different tumor stages, in order to maximize the efficacy of Keap1âNrf2 targeting agents. Keywords: Cancer prevention, Keap1, Lung cancer, Nrf2
format	article
author	Ying-Hui Tong Bo Zhang Yun Fan Neng-Ming Lin
author_facet	Ying-Hui Tong Bo Zhang Yun Fan Neng-Ming Lin
author_sort	Ying-Hui Tong
title	Keap1âNrf2 pathway: A promising target towards lung cancer prevention and therapeutics
title_short	Keap1âNrf2 pathway: A promising target towards lung cancer prevention and therapeutics
title_full	Keap1âNrf2 pathway: A promising target towards lung cancer prevention and therapeutics
title_fullStr	Keap1âNrf2 pathway: A promising target towards lung cancer prevention and therapeutics
title_full_unstemmed	Keap1âNrf2 pathway: A promising target towards lung cancer prevention and therapeutics
title_sort	keap1ânrf2 pathway: a promising target towards lung cancer prevention and therapeutics
publisher	KeAi Communications Co., Ltd.
publishDate	2015
url	https://doaj.org/article/eeda3216f74f4415abf1daac22219248
work_keys_str_mv	AT yinghuitong keap1anrf2pathwayapromisingtargettowardslungcancerpreventionandtherapeutics AT bozhang keap1anrf2pathwayapromisingtargettowardslungcancerpreventionandtherapeutics AT yunfan keap1anrf2pathwayapromisingtargettowardslungcancerpreventionandtherapeutics AT nengminglin keap1anrf2pathwayapromisingtargettowardslungcancerpreventionandtherapeutics
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Keap1âNrf2 pathway: A promising target towards lung cancer prevention and therapeutics

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