Hormone Therapy and Factors Affecting Fertility of Women Under 50-Year-Old with Breast Cancer

Mehdi Moradinazar,1 Behjat Marzbani,2 Karoon Shahebrahimi,3 Sara Shahabadi,2 Behnaz Marzbani,4 Zeinab Moradinazar5 1Research Center for Environmental Determinants of Health, School of Public Health, Kermanshah University of Medical Sciences, Kermanshah, Iran; 2Health Education and Promotion Group, V...

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Autores principales:	Moradinazar M, Marzbani B, Shahebrahimi K, Shahabadi S, Moradinazar Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	fertility contraception hormones hormone therapy breast cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/eeda374bd15446679a920c24451a3532
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spelling	oai:doaj.org-article:eeda374bd15446679a920c24451a35322021-12-02T06:24:13ZHormone Therapy and Factors Affecting Fertility of Women Under 50-Year-Old with Breast Cancer1179-1314https://doaj.org/article/eeda374bd15446679a920c24451a35322019-12-01T00:00:00Zhttps://www.dovepress.com/hormone-therapy-and-factors-affecting-fertility-of-women-under-50-year-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Mehdi Moradinazar,1 Behjat Marzbani,2 Karoon Shahebrahimi,3 Sara Shahabadi,2 Behnaz Marzbani,4 Zeinab Moradinazar5 1Research Center for Environmental Determinants of Health, School of Public Health, Kermanshah University of Medical Sciences, Kermanshah, Iran; 2Health Education and Promotion Group, Vice Chancellor for Health Affairs, Kermanshah University of Medical Sciences, Kermanshah, Iran; 3Department of Internal Medicine, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran; 4Health Education and Promotion Group, Health Network of Kermanshah, Vice Chancellor for Health Affairs, Kermanshah University of Medical Sciences, Kermanshah, Iran; 5School of Health, Kermanshah University of Medical Sciences, Kermanshah, IranCorrespondence: Behjat MarzbaniHealth Education and Promotion Group, Vice Chancellor for Health Affairs, Kermanshah University of Medical Sciences, Kermanshah, IranTel +98 9183575503Email marzbanibehjat@gmail.comBackground: Although the use of contraceptive hormones is a risk factor for development of breast cancer, level of risk is unknown; thus the current research was conducted to investigate the effect of factors related to fertility and hormone use on risk of breast cancer in women aged under 50 years old in the west of Iran.Methods: In this case-control study, all incidence cases of breast cancer aged between 25–49 years old (n=212) were selected. Twice as many as the case group, the individuals referred to other outpatient sections of the same hospital at the time of study and up to 2 years after the follow-up not diagnosed with breast or other cancers were selected as a control group. The data were collected using healthy fertility program and middle-aged periodical care forms developed by Iran’s Ministry of Health (MOH).Results: After controlling for confounding variables, history of hormonal use for contraception (OR=2.02, 95% CI=1.2–3.3) and hormone therapies (OR=1.9, 95% CI=1.2–3.04) were identified as factors increasing the risk of breast cancer. Dose-response relationships between breast cancer and the use of hormones for contraception and hormone therapy indicated that these factors increased the risk of breast cancer. The risk was found to be higher in women who had been under hormone therapy for more than 120 months. With an increase in the age of the first menstruation, risk of breast cancer increased linearly, but with an increase in the age of the first pregnancy, risk of breast cancer increased exponentially. After 20 years of age, the risk increased with a steeper slope.Conclusion: Considering the effect of hormone therapy and fertility factors on breast cancer and changeability of listed risk factors, the researchers suggest planning for sensitizing, increasing the awareness, and educating women and professionals regarding the influence of fertility and hormonal factors including pregnancy at lower ages, minimizing the use of hormones for contraception, and hormone therapy.Keywords: fertility, contraception hormones, hormone therapy, breast cancerMoradinazar MMarzbani BShahebrahimi KShahabadi SMarzbani BMoradinazar ZDove Medical Pressarticlefertilitycontraception hormoneshormone therapybreast cancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 11, Pp 309-319 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	fertility contraception hormones hormone therapy breast cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	fertility contraception hormones hormone therapy breast cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Moradinazar M Marzbani B Shahebrahimi K Shahabadi S Marzbani B Moradinazar Z Hormone Therapy and Factors Affecting Fertility of Women Under 50-Year-Old with Breast Cancer
description	Mehdi Moradinazar,1 Behjat Marzbani,2 Karoon Shahebrahimi,3 Sara Shahabadi,2 Behnaz Marzbani,4 Zeinab Moradinazar5 1Research Center for Environmental Determinants of Health, School of Public Health, Kermanshah University of Medical Sciences, Kermanshah, Iran; 2Health Education and Promotion Group, Vice Chancellor for Health Affairs, Kermanshah University of Medical Sciences, Kermanshah, Iran; 3Department of Internal Medicine, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran; 4Health Education and Promotion Group, Health Network of Kermanshah, Vice Chancellor for Health Affairs, Kermanshah University of Medical Sciences, Kermanshah, Iran; 5School of Health, Kermanshah University of Medical Sciences, Kermanshah, IranCorrespondence: Behjat MarzbaniHealth Education and Promotion Group, Vice Chancellor for Health Affairs, Kermanshah University of Medical Sciences, Kermanshah, IranTel +98 9183575503Email marzbanibehjat@gmail.comBackground: Although the use of contraceptive hormones is a risk factor for development of breast cancer, level of risk is unknown; thus the current research was conducted to investigate the effect of factors related to fertility and hormone use on risk of breast cancer in women aged under 50 years old in the west of Iran.Methods: In this case-control study, all incidence cases of breast cancer aged between 25–49 years old (n=212) were selected. Twice as many as the case group, the individuals referred to other outpatient sections of the same hospital at the time of study and up to 2 years after the follow-up not diagnosed with breast or other cancers were selected as a control group. The data were collected using healthy fertility program and middle-aged periodical care forms developed by Iran’s Ministry of Health (MOH).Results: After controlling for confounding variables, history of hormonal use for contraception (OR=2.02, 95% CI=1.2–3.3) and hormone therapies (OR=1.9, 95% CI=1.2–3.04) were identified as factors increasing the risk of breast cancer. Dose-response relationships between breast cancer and the use of hormones for contraception and hormone therapy indicated that these factors increased the risk of breast cancer. The risk was found to be higher in women who had been under hormone therapy for more than 120 months. With an increase in the age of the first menstruation, risk of breast cancer increased linearly, but with an increase in the age of the first pregnancy, risk of breast cancer increased exponentially. After 20 years of age, the risk increased with a steeper slope.Conclusion: Considering the effect of hormone therapy and fertility factors on breast cancer and changeability of listed risk factors, the researchers suggest planning for sensitizing, increasing the awareness, and educating women and professionals regarding the influence of fertility and hormonal factors including pregnancy at lower ages, minimizing the use of hormones for contraception, and hormone therapy.Keywords: fertility, contraception hormones, hormone therapy, breast cancer
format	article
author	Moradinazar M Marzbani B Shahebrahimi K Shahabadi S Marzbani B Moradinazar Z
author_facet	Moradinazar M Marzbani B Shahebrahimi K Shahabadi S Marzbani B Moradinazar Z
author_sort	Moradinazar M
title	Hormone Therapy and Factors Affecting Fertility of Women Under 50-Year-Old with Breast Cancer
title_short	Hormone Therapy and Factors Affecting Fertility of Women Under 50-Year-Old with Breast Cancer
title_full	Hormone Therapy and Factors Affecting Fertility of Women Under 50-Year-Old with Breast Cancer
title_fullStr	Hormone Therapy and Factors Affecting Fertility of Women Under 50-Year-Old with Breast Cancer
title_full_unstemmed	Hormone Therapy and Factors Affecting Fertility of Women Under 50-Year-Old with Breast Cancer
title_sort	hormone therapy and factors affecting fertility of women under 50-year-old with breast cancer
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/eeda374bd15446679a920c24451a3532
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Hormone Therapy and Factors Affecting Fertility of Women Under 50-Year-Old with Breast Cancer

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