Statins and Peripheral Arterial Disease: A Narrative Review

Peripheral arterial disease (PAD) is a highly prevalent atherosclerotic condition. In patients with PAD, the presence of intermittent claudication leads to a deterioration in quality of life. In addition, even in asymptomatic cases, patients with PAD are at high risk of cardiac or cerebrovascular ev...

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Autores principales:	Sergio Jansen-Chaparro, María D. López-Carmona, Lidia Cobos-Palacios, Jaime Sanz-Cánovas, M. Rosa Bernal-López, Ricardo Gómez-Huelgas
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	statins peripheral arterial disease cardiovascular risk amputation critical limb ischemia Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/eedbdd44b7164bd286186756619f2d22
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spelling	oai:doaj.org-article:eedbdd44b7164bd286186756619f2d222021-11-22T06:05:30ZStatins and Peripheral Arterial Disease: A Narrative Review2297-055X10.3389/fcvm.2021.777016https://doaj.org/article/eedbdd44b7164bd286186756619f2d222021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.777016/fullhttps://doaj.org/toc/2297-055XPeripheral arterial disease (PAD) is a highly prevalent atherosclerotic condition. In patients with PAD, the presence of intermittent claudication leads to a deterioration in quality of life. In addition, even in asymptomatic cases, patients with PAD are at high risk of cardiac or cerebrovascular events. Treatment of PAD is based on lifestyle modifications; regular exercise; smoking cessation; and control of cardiovascular risk factors, including hypercholesterolemia. A growing number of studies have shown that statins reduce cardiovascular risk and improve symptoms associated with PAD. Current guidelines recommend the use of statins in all patients with PAD in order to decrease cardiovascular events and mortality. However, the prescribing of statins in patients with PAD is lower than in those with coronary heart disease. This review provides relevant information from the literature that supports the use of statins in patients with PAD and shows their potential benefit in decreasing lower limb complications as well as cardiovascular morbidity and mortality.Sergio Jansen-ChaparroMaría D. López-CarmonaLidia Cobos-PalaciosJaime Sanz-CánovasM. Rosa Bernal-LópezM. Rosa Bernal-LópezRicardo Gómez-HuelgasRicardo Gómez-HuelgasFrontiers Media S.A.articlestatinsperipheral arterial diseasecardiovascular riskamputationcritical limb ischemiaDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	statins peripheral arterial disease cardiovascular risk amputation critical limb ischemia Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	statins peripheral arterial disease cardiovascular risk amputation critical limb ischemia Diseases of the circulatory (Cardiovascular) system RC666-701 Sergio Jansen-Chaparro María D. López-Carmona Lidia Cobos-Palacios Jaime Sanz-Cánovas M. Rosa Bernal-López M. Rosa Bernal-López Ricardo Gómez-Huelgas Ricardo Gómez-Huelgas Statins and Peripheral Arterial Disease: A Narrative Review
description	Peripheral arterial disease (PAD) is a highly prevalent atherosclerotic condition. In patients with PAD, the presence of intermittent claudication leads to a deterioration in quality of life. In addition, even in asymptomatic cases, patients with PAD are at high risk of cardiac or cerebrovascular events. Treatment of PAD is based on lifestyle modifications; regular exercise; smoking cessation; and control of cardiovascular risk factors, including hypercholesterolemia. A growing number of studies have shown that statins reduce cardiovascular risk and improve symptoms associated with PAD. Current guidelines recommend the use of statins in all patients with PAD in order to decrease cardiovascular events and mortality. However, the prescribing of statins in patients with PAD is lower than in those with coronary heart disease. This review provides relevant information from the literature that supports the use of statins in patients with PAD and shows their potential benefit in decreasing lower limb complications as well as cardiovascular morbidity and mortality.
format	article
author	Sergio Jansen-Chaparro María D. López-Carmona Lidia Cobos-Palacios Jaime Sanz-Cánovas M. Rosa Bernal-López M. Rosa Bernal-López Ricardo Gómez-Huelgas Ricardo Gómez-Huelgas
author_facet	Sergio Jansen-Chaparro María D. López-Carmona Lidia Cobos-Palacios Jaime Sanz-Cánovas M. Rosa Bernal-López M. Rosa Bernal-López Ricardo Gómez-Huelgas Ricardo Gómez-Huelgas
author_sort	Sergio Jansen-Chaparro
title	Statins and Peripheral Arterial Disease: A Narrative Review
title_short	Statins and Peripheral Arterial Disease: A Narrative Review
title_full	Statins and Peripheral Arterial Disease: A Narrative Review
title_fullStr	Statins and Peripheral Arterial Disease: A Narrative Review
title_full_unstemmed	Statins and Peripheral Arterial Disease: A Narrative Review
title_sort	statins and peripheral arterial disease: a narrative review
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/eedbdd44b7164bd286186756619f2d22
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Statins and Peripheral Arterial Disease: A Narrative Review

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