Inhibition of the mevalonate pathway enhances cancer cell oncolysis mediated by M1 virus

Oncolytic viruses selectively kill tumour cells and induce anti-tumour immunity. Here, the AUs demonstrate the anti-viral effect of the mevalonate pathway on oncolytic virus M1 in refractory cancer cells and provide evidence for a combination strategy of targeting the mevalonate pathway for potentia...

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Autores principales:	Jiankai Liang, Li Guo, Kai Li, Xiao Xiao, Wenbo Zhu, Xiaoke Zheng, Jun Hu, Haipeng Zhang, Jing Cai, Yaya Yu, Yaqian Tan, Chuntao Li, Xincheng Liu, Cheng Hu, Ying Liu, Pengxin Qiu, Xingwen Su, Songmin He, Yuan Lin, Guangmei Yan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eedd8026eda94f72a09d4f75de768ad5
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spelling	oai:doaj.org-article:eedd8026eda94f72a09d4f75de768ad52021-12-02T17:32:48ZInhibition of the mevalonate pathway enhances cancer cell oncolysis mediated by M1 virus10.1038/s41467-018-03913-62041-1723https://doaj.org/article/eedd8026eda94f72a09d4f75de768ad52018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03913-6https://doaj.org/toc/2041-1723Oncolytic viruses selectively kill tumour cells and induce anti-tumour immunity. Here, the AUs demonstrate the anti-viral effect of the mevalonate pathway on oncolytic virus M1 in refractory cancer cells and provide evidence for a combination strategy of targeting the mevalonate pathway for potentiating oncolytic virus therapy.Jiankai LiangLi GuoKai LiXiao XiaoWenbo ZhuXiaoke ZhengJun HuHaipeng ZhangJing CaiYaya YuYaqian TanChuntao LiXincheng LiuCheng HuYing LiuPengxin QiuXingwen SuSongmin HeYuan LinGuangmei YanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiankai Liang Li Guo Kai Li Xiao Xiao Wenbo Zhu Xiaoke Zheng Jun Hu Haipeng Zhang Jing Cai Yaya Yu Yaqian Tan Chuntao Li Xincheng Liu Cheng Hu Ying Liu Pengxin Qiu Xingwen Su Songmin He Yuan Lin Guangmei Yan Inhibition of the mevalonate pathway enhances cancer cell oncolysis mediated by M1 virus
description	Oncolytic viruses selectively kill tumour cells and induce anti-tumour immunity. Here, the AUs demonstrate the anti-viral effect of the mevalonate pathway on oncolytic virus M1 in refractory cancer cells and provide evidence for a combination strategy of targeting the mevalonate pathway for potentiating oncolytic virus therapy.
format	article
author	Jiankai Liang Li Guo Kai Li Xiao Xiao Wenbo Zhu Xiaoke Zheng Jun Hu Haipeng Zhang Jing Cai Yaya Yu Yaqian Tan Chuntao Li Xincheng Liu Cheng Hu Ying Liu Pengxin Qiu Xingwen Su Songmin He Yuan Lin Guangmei Yan
author_facet	Jiankai Liang Li Guo Kai Li Xiao Xiao Wenbo Zhu Xiaoke Zheng Jun Hu Haipeng Zhang Jing Cai Yaya Yu Yaqian Tan Chuntao Li Xincheng Liu Cheng Hu Ying Liu Pengxin Qiu Xingwen Su Songmin He Yuan Lin Guangmei Yan
author_sort	Jiankai Liang
title	Inhibition of the mevalonate pathway enhances cancer cell oncolysis mediated by M1 virus
title_short	Inhibition of the mevalonate pathway enhances cancer cell oncolysis mediated by M1 virus
title_full	Inhibition of the mevalonate pathway enhances cancer cell oncolysis mediated by M1 virus
title_fullStr	Inhibition of the mevalonate pathway enhances cancer cell oncolysis mediated by M1 virus
title_full_unstemmed	Inhibition of the mevalonate pathway enhances cancer cell oncolysis mediated by M1 virus
title_sort	inhibition of the mevalonate pathway enhances cancer cell oncolysis mediated by m1 virus
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/eedd8026eda94f72a09d4f75de768ad5
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Inhibition of the mevalonate pathway enhances cancer cell oncolysis mediated by M1 virus

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