Physical principles of retroviral integration in the human genome

Some retroviruses, including HIV, insert their DNA in a non-random manner in the host genome through a poorly understood selection mechanism. Here the authors develop a biophysical model of retroviral integration, identifying previously unnoticed universal principles that regulate this phenomenon.

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Autores principales:	D. Michieletto, M. Lusic, D. Marenduzzo, E. Orlandini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eee16ed719ac44e5aff0f7d03eec50d5
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spelling	oai:doaj.org-article:eee16ed719ac44e5aff0f7d03eec50d52021-12-02T15:35:58ZPhysical principles of retroviral integration in the human genome10.1038/s41467-019-08333-82041-1723https://doaj.org/article/eee16ed719ac44e5aff0f7d03eec50d52019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08333-8https://doaj.org/toc/2041-1723Some retroviruses, including HIV, insert their DNA in a non-random manner in the host genome through a poorly understood selection mechanism. Here the authors develop a biophysical model of retroviral integration, identifying previously unnoticed universal principles that regulate this phenomenon.D. MichielettoM. LusicD. MarenduzzoE. OrlandiniNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q D. Michieletto M. Lusic D. Marenduzzo E. Orlandini Physical principles of retroviral integration in the human genome
description	Some retroviruses, including HIV, insert their DNA in a non-random manner in the host genome through a poorly understood selection mechanism. Here the authors develop a biophysical model of retroviral integration, identifying previously unnoticed universal principles that regulate this phenomenon.
format	article
author	D. Michieletto M. Lusic D. Marenduzzo E. Orlandini
author_facet	D. Michieletto M. Lusic D. Marenduzzo E. Orlandini
author_sort	D. Michieletto
title	Physical principles of retroviral integration in the human genome
title_short	Physical principles of retroviral integration in the human genome
title_full	Physical principles of retroviral integration in the human genome
title_fullStr	Physical principles of retroviral integration in the human genome
title_full_unstemmed	Physical principles of retroviral integration in the human genome
title_sort	physical principles of retroviral integration in the human genome
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/eee16ed719ac44e5aff0f7d03eec50d5
work_keys_str_mv	AT dmichieletto physicalprinciplesofretroviralintegrationinthehumangenome AT mlusic physicalprinciplesofretroviralintegrationinthehumangenome AT dmarenduzzo physicalprinciplesofretroviralintegrationinthehumangenome AT eorlandini physicalprinciplesofretroviralintegrationinthehumangenome
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Physical principles of retroviral integration in the human genome

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