Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity

Professional antigen presenting cells (APCs) are deterred from phagocytosing cancer cells that express CD47. Here, the authors show that in glioblastoma mouse models, temozolomide improves the phagocytosis effect of CD47 blockade in APCs and results in the activation of adaptive anti-tumour response...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Christina A. von Roemeling, Yifan Wang, Yaqing Qie, Hengfeng Yuan, Hai Zhao, Xiujie Liu, Zhaogang Yang, Mingming Yang, Weiye Deng, Katelyn A. Bruno, Charles K. Chan, Andrew S. Lee, Stephen S. Rosenfeld, Kyuson Yun, Aaron J. Johnson, Duane A. Mitchell, Wen Jiang, Betty Y. S. Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eee195d796b64fada2ef877b68da61fb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:eee195d796b64fada2ef877b68da61fb
record_format	dspace
spelling	oai:doaj.org-article:eee195d796b64fada2ef877b68da61fb2021-12-02T16:56:34ZTherapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity10.1038/s41467-020-15129-82041-1723https://doaj.org/article/eee195d796b64fada2ef877b68da61fb2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15129-8https://doaj.org/toc/2041-1723Professional antigen presenting cells (APCs) are deterred from phagocytosing cancer cells that express CD47. Here, the authors show that in glioblastoma mouse models, temozolomide improves the phagocytosis effect of CD47 blockade in APCs and results in the activation of adaptive anti-tumour responses.Christina A. von RoemelingYifan WangYaqing QieHengfeng YuanHai ZhaoXiujie LiuZhaogang YangMingming YangWeiye DengKatelyn A. BrunoCharles K. ChanAndrew S. LeeStephen S. RosenfeldKyuson YunAaron J. JohnsonDuane A. MitchellWen JiangBetty Y. S. KimNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christina A. von Roemeling Yifan Wang Yaqing Qie Hengfeng Yuan Hai Zhao Xiujie Liu Zhaogang Yang Mingming Yang Weiye Deng Katelyn A. Bruno Charles K. Chan Andrew S. Lee Stephen S. Rosenfeld Kyuson Yun Aaron J. Johnson Duane A. Mitchell Wen Jiang Betty Y. S. Kim Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity
description	Professional antigen presenting cells (APCs) are deterred from phagocytosing cancer cells that express CD47. Here, the authors show that in glioblastoma mouse models, temozolomide improves the phagocytosis effect of CD47 blockade in APCs and results in the activation of adaptive anti-tumour responses.
format	article
author	Christina A. von Roemeling Yifan Wang Yaqing Qie Hengfeng Yuan Hai Zhao Xiujie Liu Zhaogang Yang Mingming Yang Weiye Deng Katelyn A. Bruno Charles K. Chan Andrew S. Lee Stephen S. Rosenfeld Kyuson Yun Aaron J. Johnson Duane A. Mitchell Wen Jiang Betty Y. S. Kim
author_facet	Christina A. von Roemeling Yifan Wang Yaqing Qie Hengfeng Yuan Hai Zhao Xiujie Liu Zhaogang Yang Mingming Yang Weiye Deng Katelyn A. Bruno Charles K. Chan Andrew S. Lee Stephen S. Rosenfeld Kyuson Yun Aaron J. Johnson Duane A. Mitchell Wen Jiang Betty Y. S. Kim
author_sort	Christina A. von Roemeling
title	Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity
title_short	Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity
title_full	Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity
title_fullStr	Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity
title_full_unstemmed	Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity
title_sort	therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/eee195d796b64fada2ef877b68da61fb
work_keys_str_mv	AT christinaavonroemeling therapeuticmodulationofphagocytosisinglioblastomacanactivatebothinnateandadaptiveantitumourimmunity AT yifanwang therapeuticmodulationofphagocytosisinglioblastomacanactivatebothinnateandadaptiveantitumourimmunity AT yaqingqie therapeuticmodulationofphagocytosisinglioblastomacanactivatebothinnateandadaptiveantitumourimmunity AT hengfengyuan therapeuticmodulationofphagocytosisinglioblastomacanactivatebothinnateandadaptiveantitumourimmunity AT haizhao therapeuticmodulationofphagocytosisinglioblastomacanactivatebothinnateandadaptiveantitumourimmunity AT xiujieliu therapeuticmodulationofphagocytosisinglioblastomacanactivatebothinnateandadaptiveantitumourimmunity AT zhaogangyang therapeuticmodulationofphagocytosisinglioblastomacanactivatebothinnateandadaptiveantitumourimmunity AT mingmingyang therapeuticmodulationofphagocytosisinglioblastomacanactivatebothinnateandadaptiveantitumourimmunity AT weiyedeng therapeuticmodulationofphagocytosisinglioblastomacanactivatebothinnateandadaptiveantitumourimmunity AT katelynabruno therapeuticmodulationofphagocytosisinglioblastomacanactivatebothinnateandadaptiveantitumourimmunity AT charleskchan therapeuticmodulationofphagocytosisinglioblastomacanactivatebothinnateandadaptiveantitumourimmunity AT andrewslee therapeuticmodulationofphagocytosisinglioblastomacanactivatebothinnateandadaptiveantitumourimmunity AT stephensrosenfeld therapeuticmodulationofphagocytosisinglioblastomacanactivatebothinnateandadaptiveantitumourimmunity AT kyusonyun therapeuticmodulationofphagocytosisinglioblastomacanactivatebothinnateandadaptiveantitumourimmunity AT aaronjjohnson therapeuticmodulationofphagocytosisinglioblastomacanactivatebothinnateandadaptiveantitumourimmunity AT duaneamitchell therapeuticmodulationofphagocytosisinglioblastomacanactivatebothinnateandadaptiveantitumourimmunity AT wenjiang therapeuticmodulationofphagocytosisinglioblastomacanactivatebothinnateandadaptiveantitumourimmunity AT bettyyskim therapeuticmodulationofphagocytosisinglioblastomacanactivatebothinnateandadaptiveantitumourimmunity
_version_	1718382833835180032

Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity

Ejemplares similares