Significance of the disc damage likelihood scale objectively measured by a non-mydriatic fundus camera in preperimetric glaucoma

Significance of the disc damage likelihood scale objectively measured by a non-mydriatic fundus camera in preperimetric glaucoma

Milena Pahlitzsch,1 Necip Torun,1 Carl Erb,2 Jeanette Bruenner,1 Anna Karina B Maier,1 Johannes Gonnermann,1 Eckart Bertelmann,1 Matthias K J Klamann1 1Department of Ophthalmology, University Medicine Charité, Campus Virchow Clinic, Berlin, 2Augenklinik am Wittenbergplatz, Berlin, German...

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Autores principales: Pahlitzsch M, Torun N, Erb C, Bruenner J, Maier AK, Gonnermann J, Bertelmann E, Klamann MKJ
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2015
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Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/eee4660c108d4cc9aaad8d3729155244
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spelling oai:doaj.org-article:eee4660c108d4cc9aaad8d37291552442021-12-02T03:40:17ZSignificance of the disc damage likelihood scale objectively measured by a non-mydriatic fundus camera in preperimetric glaucoma1177-5483https://doaj.org/article/eee4660c108d4cc9aaad8d37291552442015-11-01T00:00:00Zhttps://www.dovepress.com/significance-of-the-disc-damage-likelihood-scale-objectively-measured--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Milena Pahlitzsch,1 Necip Torun,1 Carl Erb,2 Jeanette Bruenner,1 Anna Karina B Maier,1 Johannes Gonnermann,1 Eckart Bertelmann,1 Matthias K J Klamann1 1Department of Ophthalmology, University Medicine Charité, Campus Virchow Clinic, Berlin, 2Augenklinik am Wittenbergplatz, Berlin, Germany Purpose: To assess the correlation between the disc damage likelihood scale (DDLS) objectively measured by a non-mydriatic fundus camera, Heidelberg Retina Tomograph 3, and optic coherence tomography in preperimetric glaucoma. Methods: One-hundred-twenty-five patients with preperimetric primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (n=30) were included (mean age 58.9±15.9 years). All three devices graded the optic disc topography: Diagnosis 1 was defined as “outside normal limits”, while Diagnosis 2 as “borderline or outside normal limits”. Results: For Diagnosis 1, a significant correlation was shown between DDLS and Moorfields regression analysis (P=0.022), and for Diagnosis 2 with glaucoma probability score analysis (P=0.024), in POAG. In pseudoexfoliation glaucoma, DDLS did not correlate significantly with Heidelberg Retina Tomograph 3 and optic coherence tomography. Regarding the area under the curve the highest predictive power was demonstrated by the objective DDLS (0.513–0.824) compared to Burk (0.239–0.343) and Mikelberg (0.093–0.270) coefficients. Conclusions: The DDLS showed a significant correlation to the Moorfields regression analysis in preperimetric POAG. The objective DDLS showed the highest predictive power and thus is an additive tool in diagnosing preperimetric glaucoma. Keywords: DDLS, preperimetric glaucoma, optic coherence tomography, stereophotography, Heidelberg Retina TomographPahlitzsch MTorun NErb CBruenner JMaier AKGonnermann JBertelmann EKlamann MKJDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss default, Pp 2147-2158 (2015)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Pahlitzsch M
Torun N
Erb C
Bruenner J
Maier AK
Gonnermann J
Bertelmann E
Klamann MKJ
Significance of the disc damage likelihood scale objectively measured by a non-mydriatic fundus camera in preperimetric glaucoma
description Milena Pahlitzsch,1 Necip Torun,1 Carl Erb,2 Jeanette Bruenner,1 Anna Karina B Maier,1 Johannes Gonnermann,1 Eckart Bertelmann,1 Matthias K J Klamann1 1Department of Ophthalmology, University Medicine Charité, Campus Virchow Clinic, Berlin, 2Augenklinik am Wittenbergplatz, Berlin, Germany Purpose: To assess the correlation between the disc damage likelihood scale (DDLS) objectively measured by a non-mydriatic fundus camera, Heidelberg Retina Tomograph 3, and optic coherence tomography in preperimetric glaucoma. Methods: One-hundred-twenty-five patients with preperimetric primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (n=30) were included (mean age 58.9±15.9 years). All three devices graded the optic disc topography: Diagnosis 1 was defined as “outside normal limits”, while Diagnosis 2 as “borderline or outside normal limits”. Results: For Diagnosis 1, a significant correlation was shown between DDLS and Moorfields regression analysis (P=0.022), and for Diagnosis 2 with glaucoma probability score analysis (P=0.024), in POAG. In pseudoexfoliation glaucoma, DDLS did not correlate significantly with Heidelberg Retina Tomograph 3 and optic coherence tomography. Regarding the area under the curve the highest predictive power was demonstrated by the objective DDLS (0.513–0.824) compared to Burk (0.239–0.343) and Mikelberg (0.093–0.270) coefficients. Conclusions: The DDLS showed a significant correlation to the Moorfields regression analysis in preperimetric POAG. The objective DDLS showed the highest predictive power and thus is an additive tool in diagnosing preperimetric glaucoma. Keywords: DDLS, preperimetric glaucoma, optic coherence tomography, stereophotography, Heidelberg Retina Tomograph
format article
author Pahlitzsch M
Torun N
Erb C
Bruenner J
Maier AK
Gonnermann J
Bertelmann E
Klamann MKJ
author_facet Pahlitzsch M
Torun N
Erb C
Bruenner J
Maier AK
Gonnermann J
Bertelmann E
Klamann MKJ
author_sort Pahlitzsch M
title Significance of the disc damage likelihood scale objectively measured by a non-mydriatic fundus camera in preperimetric glaucoma
title_short Significance of the disc damage likelihood scale objectively measured by a non-mydriatic fundus camera in preperimetric glaucoma
title_full Significance of the disc damage likelihood scale objectively measured by a non-mydriatic fundus camera in preperimetric glaucoma
title_fullStr Significance of the disc damage likelihood scale objectively measured by a non-mydriatic fundus camera in preperimetric glaucoma
title_full_unstemmed Significance of the disc damage likelihood scale objectively measured by a non-mydriatic fundus camera in preperimetric glaucoma
title_sort significance of the disc damage likelihood scale objectively measured by a non-mydriatic fundus camera in preperimetric glaucoma
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/eee4660c108d4cc9aaad8d3729155244
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