Janus particles: recent advances in the biomedical applications

Tu C Le,1 Jiali Zhai,2 Wei-Hsun Chiu,3 Phong A Tran,3,4 Nhiem Tran21School of Engineering, RMIT University, Melbourne, VIC 3001, Australia; 2School of Science, RMIT University, Melbourne, VIC 3001, Australia; 3School of Chemistry, Physics and Mechanical Engineering, Science and Engineering Faculty,...

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Autores principales:	Le TC, Zhai J, Chiu WH, Tran PA, Tran N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Janus particles therapeutics theranostics imaging sensing Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/eee7be04cbce4ebe9dd7a37954075947
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spelling	oai:doaj.org-article:eee7be04cbce4ebe9dd7a379540759472021-12-02T09:25:25ZJanus particles: recent advances in the biomedical applications1178-2013https://doaj.org/article/eee7be04cbce4ebe9dd7a379540759472019-08-01T00:00:00Zhttps://www.dovepress.com/janus-particles-recent-advances-in-the-biomedical-applications-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Tu C Le,1 Jiali Zhai,2 Wei-Hsun Chiu,3 Phong A Tran,3,4 Nhiem Tran21School of Engineering, RMIT University, Melbourne, VIC 3001, Australia; 2School of Science, RMIT University, Melbourne, VIC 3001, Australia; 3School of Chemistry, Physics and Mechanical Engineering, Science and Engineering Faculty, Queensland University of Technology, Brisbane, QLD 4000, Australia; 4Interface Science and Materials Engineering group, School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD 4000, AustraliaCorrespondence: Nhiem TranSchool of Science, RMIT University, 124 La Trobe Street, Melbourne VIC 3000, AustraliaTel +61 3 9925 2131Email Nhiem.tran@rmit.edu.auAbstract: Janus particles, which are named after the two-faced Roman god Janus, have two distinct sides with different surface features, structures, and compositions. This asymmetric structure enables the combination of different or even incompatible physical, chemical, and mechanical properties within a single particle. Much effort has been focused on the preparation of Janus particles with high homogeneity, tunable size and shape, combined functionalities, and scalability. With their unique features, Janus particles have attracted attention in a wide range of applications such as in optics, catalysis, and biomedicine. As a biomedical device, Janus particles offer opportunities to incorporate therapeutics, imaging, or sensing modalities in independent compartments of a single particle in a spatially controlled manner. This may result in synergistic actions of combined therapies and multi-level targeting not possible in isotropic systems. In this review, we summarize the latest advances in employing Janus particles as therapeutic delivery carriers, in vivo imaging probes, and biosensors. Challenges and future opportunities for these particles will also be discussed.Keywords: Janus particles, therapeutics, theranostics, imaging, sensingLe TCZhai JChiu WHTran PATran NDove Medical PressarticleJanus particlestherapeuticstheranosticsimagingsensingMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 6749-6777 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Janus particles therapeutics theranostics imaging sensing Medicine (General) R5-920
spellingShingle	Janus particles therapeutics theranostics imaging sensing Medicine (General) R5-920 Le TC Zhai J Chiu WH Tran PA Tran N Janus particles: recent advances in the biomedical applications
description	Tu C Le,1 Jiali Zhai,2 Wei-Hsun Chiu,3 Phong A Tran,3,4 Nhiem Tran21School of Engineering, RMIT University, Melbourne, VIC 3001, Australia; 2School of Science, RMIT University, Melbourne, VIC 3001, Australia; 3School of Chemistry, Physics and Mechanical Engineering, Science and Engineering Faculty, Queensland University of Technology, Brisbane, QLD 4000, Australia; 4Interface Science and Materials Engineering group, School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD 4000, AustraliaCorrespondence: Nhiem TranSchool of Science, RMIT University, 124 La Trobe Street, Melbourne VIC 3000, AustraliaTel +61 3 9925 2131Email Nhiem.tran@rmit.edu.auAbstract: Janus particles, which are named after the two-faced Roman god Janus, have two distinct sides with different surface features, structures, and compositions. This asymmetric structure enables the combination of different or even incompatible physical, chemical, and mechanical properties within a single particle. Much effort has been focused on the preparation of Janus particles with high homogeneity, tunable size and shape, combined functionalities, and scalability. With their unique features, Janus particles have attracted attention in a wide range of applications such as in optics, catalysis, and biomedicine. As a biomedical device, Janus particles offer opportunities to incorporate therapeutics, imaging, or sensing modalities in independent compartments of a single particle in a spatially controlled manner. This may result in synergistic actions of combined therapies and multi-level targeting not possible in isotropic systems. In this review, we summarize the latest advances in employing Janus particles as therapeutic delivery carriers, in vivo imaging probes, and biosensors. Challenges and future opportunities for these particles will also be discussed.Keywords: Janus particles, therapeutics, theranostics, imaging, sensing
format	article
author	Le TC Zhai J Chiu WH Tran PA Tran N
author_facet	Le TC Zhai J Chiu WH Tran PA Tran N
author_sort	Le TC
title	Janus particles: recent advances in the biomedical applications
title_short	Janus particles: recent advances in the biomedical applications
title_full	Janus particles: recent advances in the biomedical applications
title_fullStr	Janus particles: recent advances in the biomedical applications
title_full_unstemmed	Janus particles: recent advances in the biomedical applications
title_sort	janus particles: recent advances in the biomedical applications
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/eee7be04cbce4ebe9dd7a37954075947
work_keys_str_mv	AT letc janusparticlesrecentadvancesinthebiomedicalapplications AT zhaij janusparticlesrecentadvancesinthebiomedicalapplications AT chiuwh janusparticlesrecentadvancesinthebiomedicalapplications AT tranpa janusparticlesrecentadvancesinthebiomedicalapplications AT trann janusparticlesrecentadvancesinthebiomedicalapplications
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Janus particles: recent advances in the biomedical applications

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