Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis

The structure of human tumor suppressor p53 in complex with the antiapoptotic protein BCL-xL reveals the basis of the p53–BCL-xL interaction and provides insight into the mechanisms of p53-mediated mitochondrial apoptosis.

Guardado en:

Detalles Bibliográficos
Autores principales:	Hudie Wei, Lingzhi Qu, Shuyan Dai, Yun Li, Haolan Wang, Yilu Feng, Xiaojuan Chen, Longying Jiang, Ming Guo, Jun Li, Zhuchu Chen, Lin Chen, Ye Zhang, Yongheng Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eee86fb8caf449e7a93cc5a90e776ac6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:eee86fb8caf449e7a93cc5a90e776ac6
record_format	dspace
spelling	oai:doaj.org-article:eee86fb8caf449e7a93cc5a90e776ac62021-12-02T15:51:06ZStructural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis10.1038/s41467-021-22655-62041-1723https://doaj.org/article/eee86fb8caf449e7a93cc5a90e776ac62021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22655-6https://doaj.org/toc/2041-1723The structure of human tumor suppressor p53 in complex with the antiapoptotic protein BCL-xL reveals the basis of the p53–BCL-xL interaction and provides insight into the mechanisms of p53-mediated mitochondrial apoptosis.Hudie WeiLingzhi QuShuyan DaiYun LiHaolan WangYilu FengXiaojuan ChenLongying JiangMing GuoJun LiZhuchu ChenLin ChenYe ZhangYongheng ChenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hudie Wei Lingzhi Qu Shuyan Dai Yun Li Haolan Wang Yilu Feng Xiaojuan Chen Longying Jiang Ming Guo Jun Li Zhuchu Chen Lin Chen Ye Zhang Yongheng Chen Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis
description	The structure of human tumor suppressor p53 in complex with the antiapoptotic protein BCL-xL reveals the basis of the p53–BCL-xL interaction and provides insight into the mechanisms of p53-mediated mitochondrial apoptosis.
format	article
author	Hudie Wei Lingzhi Qu Shuyan Dai Yun Li Haolan Wang Yilu Feng Xiaojuan Chen Longying Jiang Ming Guo Jun Li Zhuchu Chen Lin Chen Ye Zhang Yongheng Chen
author_facet	Hudie Wei Lingzhi Qu Shuyan Dai Yun Li Haolan Wang Yilu Feng Xiaojuan Chen Longying Jiang Ming Guo Jun Li Zhuchu Chen Lin Chen Ye Zhang Yongheng Chen
author_sort	Hudie Wei
title	Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis
title_short	Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis
title_full	Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis
title_fullStr	Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis
title_full_unstemmed	Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis
title_sort	structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/eee86fb8caf449e7a93cc5a90e776ac6
work_keys_str_mv	AT hudiewei structuralinsightintothemolecularmechanismofp53mediatedmitochondrialapoptosis AT lingzhiqu structuralinsightintothemolecularmechanismofp53mediatedmitochondrialapoptosis AT shuyandai structuralinsightintothemolecularmechanismofp53mediatedmitochondrialapoptosis AT yunli structuralinsightintothemolecularmechanismofp53mediatedmitochondrialapoptosis AT haolanwang structuralinsightintothemolecularmechanismofp53mediatedmitochondrialapoptosis AT yilufeng structuralinsightintothemolecularmechanismofp53mediatedmitochondrialapoptosis AT xiaojuanchen structuralinsightintothemolecularmechanismofp53mediatedmitochondrialapoptosis AT longyingjiang structuralinsightintothemolecularmechanismofp53mediatedmitochondrialapoptosis AT mingguo structuralinsightintothemolecularmechanismofp53mediatedmitochondrialapoptosis AT junli structuralinsightintothemolecularmechanismofp53mediatedmitochondrialapoptosis AT zhuchuchen structuralinsightintothemolecularmechanismofp53mediatedmitochondrialapoptosis AT linchen structuralinsightintothemolecularmechanismofp53mediatedmitochondrialapoptosis AT yezhang structuralinsightintothemolecularmechanismofp53mediatedmitochondrialapoptosis AT yonghengchen structuralinsightintothemolecularmechanismofp53mediatedmitochondrialapoptosis
_version_	1718385666734161920

Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis

Ejemplares similares