Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency

The mechanisms driving lung inflammation and remodelling in chronic obstructive pulmonary disease (COPD) are incompletely understood. Here the authors show that lack of secretory IgA promotes bacterial invasion in small airways, resulting in leukocyte recruitment and a COPD-like phenotype.

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Autores principales:	Bradley W. Richmond, Robert M. Brucker, Wei Han, Rui-Hong Du, Yongqin Zhang, Dong-Sheng Cheng, Linda Gleaves, Rasul Abdolrasulnia, Dina Polosukhina, Peter E. Clark, Seth R. Bordenstein, Timothy S. Blackwell, Vasiliy V. Polosukhin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eeec5588ef414eeb90b7ce8b57b17590
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spelling	oai:doaj.org-article:eeec5588ef414eeb90b7ce8b57b175902021-12-02T15:35:46ZAirway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency10.1038/ncomms112402041-1723https://doaj.org/article/eeec5588ef414eeb90b7ce8b57b175902016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11240https://doaj.org/toc/2041-1723The mechanisms driving lung inflammation and remodelling in chronic obstructive pulmonary disease (COPD) are incompletely understood. Here the authors show that lack of secretory IgA promotes bacterial invasion in small airways, resulting in leukocyte recruitment and a COPD-like phenotype.Bradley W. RichmondRobert M. BruckerWei HanRui-Hong DuYongqin ZhangDong-Sheng ChengLinda GleavesRasul AbdolrasulniaDina PolosukhinaPeter E. ClarkSeth R. BordensteinTimothy S. BlackwellVasiliy V. PolosukhinNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bradley W. Richmond Robert M. Brucker Wei Han Rui-Hong Du Yongqin Zhang Dong-Sheng Cheng Linda Gleaves Rasul Abdolrasulnia Dina Polosukhina Peter E. Clark Seth R. Bordenstein Timothy S. Blackwell Vasiliy V. Polosukhin Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency
description	The mechanisms driving lung inflammation and remodelling in chronic obstructive pulmonary disease (COPD) are incompletely understood. Here the authors show that lack of secretory IgA promotes bacterial invasion in small airways, resulting in leukocyte recruitment and a COPD-like phenotype.
format	article
author	Bradley W. Richmond Robert M. Brucker Wei Han Rui-Hong Du Yongqin Zhang Dong-Sheng Cheng Linda Gleaves Rasul Abdolrasulnia Dina Polosukhina Peter E. Clark Seth R. Bordenstein Timothy S. Blackwell Vasiliy V. Polosukhin
author_facet	Bradley W. Richmond Robert M. Brucker Wei Han Rui-Hong Du Yongqin Zhang Dong-Sheng Cheng Linda Gleaves Rasul Abdolrasulnia Dina Polosukhina Peter E. Clark Seth R. Bordenstein Timothy S. Blackwell Vasiliy V. Polosukhin
author_sort	Bradley W. Richmond
title	Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency
title_short	Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency
title_full	Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency
title_fullStr	Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency
title_full_unstemmed	Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency
title_sort	airway bacteria drive a progressive copd-like phenotype in mice with polymeric immunoglobulin receptor deficiency
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/eeec5588ef414eeb90b7ce8b57b17590
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Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency

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