Optoplasmonic characterisation of reversible disulfide interactions at single thiol sites in the attomolar regime

Visualising single-molecule reactions, to understand their mechanisms, is a challenging task. Here, the authors investigate disulfide exchange reactions with thiolates immobilised on a gold nanoparticle through a label-free optoplasmonic sensor, and detect individual disulfide interactions in soluti...

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Autores principales: Serge Vincent, Sivaraman Subramanian, Frank Vollmer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/eeedabbbdb884722a111c2aae36adeca
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Sumario:Visualising single-molecule reactions, to understand their mechanisms, is a challenging task. Here, the authors investigate disulfide exchange reactions with thiolates immobilised on a gold nanoparticle through a label-free optoplasmonic sensor, and detect individual disulfide interactions in solution