Is It Possible? A Different Approach to Creating a Universal Influenza Vaccine

ABSTRACT The best way to combat influenza virus infection is to prevent it. However, the continual evolution of circulating influenza virus strains and the constant threat of newly emerging viruses forces the public health community to annually update seasonal influenza vaccines while stockpiling po...

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Autor principal:	Stacey Schultz-Cherry
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2015
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/eef29d37832c444ea35fa798bb880868
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spelling	oai:doaj.org-article:eef29d37832c444ea35fa798bb8808682021-11-15T15:41:31ZIs It Possible? A Different Approach to Creating a Universal Influenza Vaccine10.1128/mBio.01580-152150-7511https://doaj.org/article/eef29d37832c444ea35fa798bb8808682015-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01580-15https://doaj.org/toc/2150-7511ABSTRACT The best way to combat influenza virus infection is to prevent it. However, the continual evolution of circulating influenza virus strains and the constant threat of newly emerging viruses forces the public health community to annually update seasonal influenza vaccines while stockpiling potential pandemic virus vaccines. Thus, there is an urgent need to develop a “universal” influenza vaccine that affords protection against all strains. In their recent article, L. M. Schwartzman et al. (mBio 6:e01044-15, 2015, doi:10.1128/mBio.01044-15) demonstrated that intranasal immunization of mice with a cocktail of viral-like particles (VLPs) expressing distinct influenza virus hemagglutinin (HA) proteins can broadly protect against infection not only with the same viral strains but also with unrelated strains. These findings suggest a promising strategy for developing a broadly protective “universal” influenza vaccine.Stacey Schultz-CherryAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 6, Iss 5 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Stacey Schultz-Cherry Is It Possible? A Different Approach to Creating a Universal Influenza Vaccine
description	ABSTRACT The best way to combat influenza virus infection is to prevent it. However, the continual evolution of circulating influenza virus strains and the constant threat of newly emerging viruses forces the public health community to annually update seasonal influenza vaccines while stockpiling potential pandemic virus vaccines. Thus, there is an urgent need to develop a “universal” influenza vaccine that affords protection against all strains. In their recent article, L. M. Schwartzman et al. (mBio 6:e01044-15, 2015, doi:10.1128/mBio.01044-15) demonstrated that intranasal immunization of mice with a cocktail of viral-like particles (VLPs) expressing distinct influenza virus hemagglutinin (HA) proteins can broadly protect against infection not only with the same viral strains but also with unrelated strains. These findings suggest a promising strategy for developing a broadly protective “universal” influenza vaccine.
format	article
author	Stacey Schultz-Cherry
author_facet	Stacey Schultz-Cherry
author_sort	Stacey Schultz-Cherry
title	Is It Possible? A Different Approach to Creating a Universal Influenza Vaccine
title_short	Is It Possible? A Different Approach to Creating a Universal Influenza Vaccine
title_full	Is It Possible? A Different Approach to Creating a Universal Influenza Vaccine
title_fullStr	Is It Possible? A Different Approach to Creating a Universal Influenza Vaccine
title_full_unstemmed	Is It Possible? A Different Approach to Creating a Universal Influenza Vaccine
title_sort	is it possible? a different approach to creating a universal influenza vaccine
publisher	American Society for Microbiology
publishDate	2015
url	https://doaj.org/article/eef29d37832c444ea35fa798bb880868
work_keys_str_mv	AT staceyschultzcherry isitpossibleadifferentapproachtocreatingauniversalinfluenzavaccine
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Is It Possible? A Different Approach to Creating a Universal Influenza Vaccine

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