UAF1 deubiquitinase complexes facilitate NLRP3 inflammasome activation by promoting NLRP3 expression

NLRP3 inflammasome activation is regulated by various signaling pathways to ensure inflammation does not go unchecked. Here the authors show how deubiquitination avoids this regulation to activate the NLRP3 inflammasome through the function of UAF1/USP deubiquitinase complexes.

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Auteurs principaux:	Hui Song, Chunyuan Zhao, Zhongxia Yu, Qizhao Li, Rongzhen Yan, Ying Qin, Mutian Jia, Wei Zhao
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/eef5b96d0c054b80adaa460a083c9c3c
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spelling	oai:doaj.org-article:eef5b96d0c054b80adaa460a083c9c3c2021-12-02T15:39:17ZUAF1 deubiquitinase complexes facilitate NLRP3 inflammasome activation by promoting NLRP3 expression10.1038/s41467-020-19939-82041-1723https://doaj.org/article/eef5b96d0c054b80adaa460a083c9c3c2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19939-8https://doaj.org/toc/2041-1723NLRP3 inflammasome activation is regulated by various signaling pathways to ensure inflammation does not go unchecked. Here the authors show how deubiquitination avoids this regulation to activate the NLRP3 inflammasome through the function of UAF1/USP deubiquitinase complexes.Hui SongChunyuan ZhaoZhongxia YuQizhao LiRongzhen YanYing QinMutian JiaWei ZhaoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hui Song Chunyuan Zhao Zhongxia Yu Qizhao Li Rongzhen Yan Ying Qin Mutian Jia Wei Zhao UAF1 deubiquitinase complexes facilitate NLRP3 inflammasome activation by promoting NLRP3 expression
description	NLRP3 inflammasome activation is regulated by various signaling pathways to ensure inflammation does not go unchecked. Here the authors show how deubiquitination avoids this regulation to activate the NLRP3 inflammasome through the function of UAF1/USP deubiquitinase complexes.
format	article
author	Hui Song Chunyuan Zhao Zhongxia Yu Qizhao Li Rongzhen Yan Ying Qin Mutian Jia Wei Zhao
author_facet	Hui Song Chunyuan Zhao Zhongxia Yu Qizhao Li Rongzhen Yan Ying Qin Mutian Jia Wei Zhao
author_sort	Hui Song
title	UAF1 deubiquitinase complexes facilitate NLRP3 inflammasome activation by promoting NLRP3 expression
title_short	UAF1 deubiquitinase complexes facilitate NLRP3 inflammasome activation by promoting NLRP3 expression
title_full	UAF1 deubiquitinase complexes facilitate NLRP3 inflammasome activation by promoting NLRP3 expression
title_fullStr	UAF1 deubiquitinase complexes facilitate NLRP3 inflammasome activation by promoting NLRP3 expression
title_full_unstemmed	UAF1 deubiquitinase complexes facilitate NLRP3 inflammasome activation by promoting NLRP3 expression
title_sort	uaf1 deubiquitinase complexes facilitate nlrp3 inflammasome activation by promoting nlrp3 expression
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/eef5b96d0c054b80adaa460a083c9c3c
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UAF1 deubiquitinase complexes facilitate NLRP3 inflammasome activation by promoting NLRP3 expression

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