Short-Course of Methylprednisolone Improves Respiratory Functional Parameters After 120 Days in Hospitalized COVID-19 Patients (Metcovid Trial): A Randomized Clinical Trial

Background: The use of corticosteroids may help control the cytokine storm occurring in acute respiratory failure due to the severe form of COVID-19. We evaluated the postacute effect of corticosteroids used during the acute phase, such as impairment in pulmonary function parameters, on day 120 (D12...

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Autores principales:	Camila Miriam Suemi Sato Barros, Raissa Soares Freire, Elisângela Frota, Anna Gabriela Rezende Santos, Maria Eduarda Leão Farias, Maria Gabriela Almeida Rodrigues, Bernardo Maia Silva, Christiane Maria Prado Jeronimo, Rebeca Linhares Abreu Netto, Mayla Gabriela Silva Borba, Djane Baía-da-Silva, José Diego Brito-Sousa, Mariana Simão Xavier, Marcia Almeida Araújo-Alexandre, Vanderson Souza Sampaio, Gisely Cardoso Melo, Guilherme Tinoco Arêas, Ludhmila Abrahão Hajjar, Wuelton Marcelo Monteiro, Felipe Gomes Naveca, Fábio Trindade Maranhão Costa, Fernando Fonseca Almeida Val, Marcus Vinícius Guimarães Lacerda, The Metcovid team, Adria de Lemos Vasconcelos, Adriana Ferreira Praia Marins, Alexandre de Oliveira Trindade, Aline Sales Mendes Záu, Amanda Carvalho de Oliveira, Ana Carolina Azevedo Furtado, Ana Paula Coelho Rocha, Anderson da Silva Souza, Andiana de Souza Dias, Aníbal Belém, Antonny Michael da Silva Sousa, Beatriz França da Silva, Beatriz Leitão Franco, Bleno Leonam Gonçalves da Costa, Carla C. Judice, Carlos Eduardo Padron de Morais, Danielle Severino Sena da Silva, Debora Camila Gomes Duarte, Ejandre Garcia Negreiros da Silva, Elias da Silva Lemos, Elizandra Freitas do Nascimento, Elson Silva de Almeida, Elyana Almeida Marques, Emanuel Medeiros Marinho de Almeida, Emanuelle Lira da Silva, Ester Galvão dos Santos, Ezequiel da Silva Oliveira, Fábio Manabu Martins Shimizu, Fabíola Ramalho Ferreira de Souza, Felipe da Silva do Vale, Fernanda dos Santos de Almeida Lima, Fernando Hugo Jesus da Fonseca, Flávia Alencar Fontenelle, Francielen de Azevedo Furtado, Gabrielle Da Silva Pereira, Geísa Aleixo Bezerra, Guilherme Kemeron Maciel Salazar, Handerson da Silva Pereira, Hilda Ferreira de Melo, Ingrid Nascimento Oliveira, Ivanildo Vieira Pereira Filho, Jaily e Silva Rosa, Jacimara Vasques Gomes, Jonas Mota Lemos, Josué Nélio Brutus, Karina Pinheiro Pessoa, Laleyska Deucylane Costa Rodrigues, Larissa Esthefani Barros Cirino, Lauro Fragata Mourão Filho, Leandro Moura, Lorenna Pereira de Souza, Lucas Barbosa Oliveira, Marcela Menezes dos Santos, Marcus Vinicius Ramos da Silva, Mauro Pereira Rodrigues, Mayara Tavares de Menezes, Micaela Maciel dos Santos Mota, Nadya Fonseca Corrêa, Najara Bittencourt, Nagila Morais Rocha, Natália Guedes de Melo Silva, Priscilla de Oliveira Saraiva, Quézia de Sousa Monteiro, Rafael Theodoro dos Santos, Rebecca Augusta de Araújo Pinto, Rodrigo Saboia de Lima Reinan Brotas Ferreira, Rosângela Francisca Tanantas de Melo, Sabrina Teixeira Saenz, Salete Sara Alvarez Fernandes, Sheila Vítor-Silva, Thalie Cavalcante Santos, Tânia Maria Rodrigues de Oliveira, Tatyana A. Tavella, Thais Tavares Câmara, Thiago Serrão Pinto, Tilza Waleska Rocha dos Santos, Valdinete Alves do Nascimento, Wanessa Pessoa Sousa Barbosa, Wellinthon Ferreira de Melo, Wlademir Braga Salgad Sobrinho
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	SARS-CoV-2 COVID-19 pulmonary function test long-covid corticosteroid inflammation Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/eefc9d7a28cf4f8e89be2a8b74039465
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:eefc9d7a28cf4f8e89be2a8b74039465
record_format	dspace
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 COVID-19 pulmonary function test long-covid corticosteroid inflammation Medicine (General) R5-920
spellingShingle	SARS-CoV-2 COVID-19 pulmonary function test long-covid corticosteroid inflammation Medicine (General) R5-920 Camila Miriam Suemi Sato Barros Camila Miriam Suemi Sato Barros Raissa Soares Freire Raissa Soares Freire Elisângela Frota Elisângela Frota Anna Gabriela Rezende Santos Anna Gabriela Rezende Santos Maria Eduarda Leão Farias Maria Gabriela Almeida Rodrigues Maria Gabriela Almeida Rodrigues Bernardo Maia Silva Bernardo Maia Silva Christiane Maria Prado Jeronimo Christiane Maria Prado Jeronimo Rebeca Linhares Abreu Netto Rebeca Linhares Abreu Netto Mayla Gabriela Silva Borba Mayla Gabriela Silva Borba Djane Baía-da-Silva Djane Baía-da-Silva José Diego Brito-Sousa José Diego Brito-Sousa Mariana Simão Xavier Marcia Almeida Araújo-Alexandre Vanderson Souza Sampaio Vanderson Souza Sampaio Vanderson Souza Sampaio Gisely Cardoso Melo Gisely Cardoso Melo Guilherme Tinoco Arêas Ludhmila Abrahão Hajjar Wuelton Marcelo Monteiro Wuelton Marcelo Monteiro Felipe Gomes Naveca Fábio Trindade Maranhão Costa Fernando Fonseca Almeida Val Fernando Fonseca Almeida Val Fernando Fonseca Almeida Val Marcus Vinícius Guimarães Lacerda Marcus Vinícius Guimarães Lacerda Marcus Vinícius Guimarães Lacerda The Metcovid team Adria de Lemos Vasconcelos Adriana Ferreira Praia Marins Alexandre de Oliveira Trindade Aline Sales Mendes Záu Amanda Carvalho de Oliveira Ana Carolina Azevedo Furtado Ana Paula Coelho Rocha Anderson da Silva Souza Andiana de Souza Dias Aníbal Belém Antonny Michael da Silva Sousa Beatriz França da Silva Beatriz Leitão Franco Bleno Leonam Gonçalves da Costa Carla C. Judice Carlos Eduardo Padron de Morais Danielle Severino Sena da Silva Debora Camila Gomes Duarte Ejandre Garcia Negreiros da Silva Elias da Silva Lemos Elizandra Freitas do Nascimento Elson Silva de Almeida Elyana Almeida Marques Emanuel Medeiros Marinho de Almeida Emanuelle Lira da Silva Ester Galvão dos Santos Ezequiel da Silva Oliveira Fábio Manabu Martins Shimizu Fabíola Ramalho Ferreira de Souza Felipe da Silva do Vale Fernanda dos Santos de Almeida Lima Fernando Hugo Jesus da Fonseca Flávia Alencar Fontenelle Francielen de Azevedo Furtado Gabrielle Da Silva Pereira Geísa Aleixo Bezerra Guilherme Kemeron Maciel Salazar Handerson da Silva Pereira Hilda Ferreira de Melo Ingrid Nascimento Oliveira Ivanildo Vieira Pereira Filho Jaily e Silva Rosa Jacimara Vasques Gomes Jonas Mota Lemos Josué Nélio Brutus Karina Pinheiro Pessoa Laleyska Deucylane Costa Rodrigues Larissa Esthefani Barros Cirino Lauro Fragata Mourão Filho Leandro Moura Lorenna Pereira de Souza Lucas Barbosa Oliveira Marcela Menezes dos Santos Marcus Vinicius Ramos da Silva Mauro Pereira Rodrigues Mayara Tavares de Menezes Micaela Maciel dos Santos Mota Nadya Fonseca Corrêa Najara Bittencourt Nagila Morais Rocha Natália Guedes de Melo Silva Priscilla de Oliveira Saraiva Quézia de Sousa Monteiro Rafael Theodoro dos Santos Rebecca Augusta de Araújo Pinto Rodrigo Saboia de Lima Reinan Brotas Ferreira Rosângela Francisca Tanantas de Melo Sabrina Teixeira Saenz Salete Sara Alvarez Fernandes Sheila Vítor-Silva Thalie Cavalcante Santos Tânia Maria Rodrigues de Oliveira Tatyana A. Tavella Thais Tavares Câmara Thiago Serrão Pinto Tilza Waleska Rocha dos Santos Valdinete Alves do Nascimento Wanessa Pessoa Sousa Barbosa Wellinthon Ferreira de Melo Wlademir Braga Salgad Sobrinho Short-Course of Methylprednisolone Improves Respiratory Functional Parameters After 120 Days in Hospitalized COVID-19 Patients (Metcovid Trial): A Randomized Clinical Trial
description	Background: The use of corticosteroids may help control the cytokine storm occurring in acute respiratory failure due to the severe form of COVID-19. We evaluated the postacute effect of corticosteroids used during the acute phase, such as impairment in pulmonary function parameters, on day 120 (D120)-follow-up, in participants who survived over 28 days.Methods: This is a parallel, double-blind, randomized, placebo-controlled phase IIb clinical trial carried out between April 18 and October 9, 2020, conducted in hospitalized patients with clinical–radiological suspicion of COVID-19, aged 18 years or older, with SpO2 ≤ 94% on room air or requiring supplementary oxygen, or under invasive mechanical ventilation (IMV) in a referral center in Manaus, Western Brazilian Amazon. Intravenous methylprednisolone (MP) (0.5 mg/kg) was given two times daily for 5 days to these patients. The primary outcome used for this study was pulmonary function testing at day 120 follow-up visit.Results: Out of the total of surviving patients at day 28 (n = 246) from the Metcovid study, a total of 118 underwent satisfactory pulmonary function testing (62 in the placebo arm and 56 in the MP arm). The supportive treatment was similar between the placebo and MP groups (seven [11%] vs. four [7%]; P = 0.45). At hospital admission, IL-6 levels were higher in the MP group (P < 0.01). Also, the need for ICU (P = 0.06), need for IMV (P = 0.07), and creatine kinase (P = 0.05) on admission also tended to be higher in this group. In the univariate analysis, forced expiratory volume on 1st second of exhalation (FEV1) and forced vital capacity (FVC) at D120 follow-up were significantly higher in patients in the MP arm, being this last parameter also significantly higher in the multivariate analysis independently of IMV and IL-6 levels on admission.Conclusion: The use of steroids for at least 5 days in severe COVID-19 was associated with a higher FVC, which suggests that hospitalized COVID-19 patients might benefit from the use of MP in its use in the long-term, with less pulmonary restrictive functions, attributed to fibrosis.Trial Registration:ClinicalTrials.gov, Identifier: NCT04343729.
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author	Camila Miriam Suemi Sato Barros Camila Miriam Suemi Sato Barros Raissa Soares Freire Raissa Soares Freire Elisângela Frota Elisângela Frota Anna Gabriela Rezende Santos Anna Gabriela Rezende Santos Maria Eduarda Leão Farias Maria Gabriela Almeida Rodrigues Maria Gabriela Almeida Rodrigues Bernardo Maia Silva Bernardo Maia Silva Christiane Maria Prado Jeronimo Christiane Maria Prado Jeronimo Rebeca Linhares Abreu Netto Rebeca Linhares Abreu Netto Mayla Gabriela Silva Borba Mayla Gabriela Silva Borba Djane Baía-da-Silva Djane Baía-da-Silva José Diego Brito-Sousa José Diego Brito-Sousa Mariana Simão Xavier Marcia Almeida Araújo-Alexandre Vanderson Souza Sampaio Vanderson Souza Sampaio Vanderson Souza Sampaio Gisely Cardoso Melo Gisely Cardoso Melo Guilherme Tinoco Arêas Ludhmila Abrahão Hajjar Wuelton Marcelo Monteiro Wuelton Marcelo Monteiro Felipe Gomes Naveca Fábio Trindade Maranhão Costa Fernando Fonseca Almeida Val Fernando Fonseca Almeida Val Fernando Fonseca Almeida Val Marcus Vinícius Guimarães Lacerda Marcus Vinícius Guimarães Lacerda Marcus Vinícius Guimarães Lacerda The Metcovid team Adria de Lemos Vasconcelos Adriana Ferreira Praia Marins Alexandre de Oliveira Trindade Aline Sales Mendes Záu Amanda Carvalho de Oliveira Ana Carolina Azevedo Furtado Ana Paula Coelho Rocha Anderson da Silva Souza Andiana de Souza Dias Aníbal Belém Antonny Michael da Silva Sousa Beatriz França da Silva Beatriz Leitão Franco Bleno Leonam Gonçalves da Costa Carla C. Judice Carlos Eduardo Padron de Morais Danielle Severino Sena da Silva Debora Camila Gomes Duarte Ejandre Garcia Negreiros da Silva Elias da Silva Lemos Elizandra Freitas do Nascimento Elson Silva de Almeida Elyana Almeida Marques Emanuel Medeiros Marinho de Almeida Emanuelle Lira da Silva Ester Galvão dos Santos Ezequiel da Silva Oliveira Fábio Manabu Martins Shimizu Fabíola Ramalho Ferreira de Souza Felipe da Silva do Vale Fernanda dos Santos de Almeida Lima Fernando Hugo Jesus da Fonseca Flávia Alencar Fontenelle Francielen de Azevedo Furtado Gabrielle Da Silva Pereira Geísa Aleixo Bezerra Guilherme Kemeron Maciel Salazar Handerson da Silva Pereira Hilda Ferreira de Melo Ingrid Nascimento Oliveira Ivanildo Vieira Pereira Filho Jaily e Silva Rosa Jacimara Vasques Gomes Jonas Mota Lemos Josué Nélio Brutus Karina Pinheiro Pessoa Laleyska Deucylane Costa Rodrigues Larissa Esthefani Barros Cirino Lauro Fragata Mourão Filho Leandro Moura Lorenna Pereira de Souza Lucas Barbosa Oliveira Marcela Menezes dos Santos Marcus Vinicius Ramos da Silva Mauro Pereira Rodrigues Mayara Tavares de Menezes Micaela Maciel dos Santos Mota Nadya Fonseca Corrêa Najara Bittencourt Nagila Morais Rocha Natália Guedes de Melo Silva Priscilla de Oliveira Saraiva Quézia de Sousa Monteiro Rafael Theodoro dos Santos Rebecca Augusta de Araújo Pinto Rodrigo Saboia de Lima Reinan Brotas Ferreira Rosângela Francisca Tanantas de Melo Sabrina Teixeira Saenz Salete Sara Alvarez Fernandes Sheila Vítor-Silva Thalie Cavalcante Santos Tânia Maria Rodrigues de Oliveira Tatyana A. Tavella Thais Tavares Câmara Thiago Serrão Pinto Tilza Waleska Rocha dos Santos Valdinete Alves do Nascimento Wanessa Pessoa Sousa Barbosa Wellinthon Ferreira de Melo Wlademir Braga Salgad Sobrinho
author_facet	Camila Miriam Suemi Sato Barros Camila Miriam Suemi Sato Barros Raissa Soares Freire Raissa Soares Freire Elisângela Frota Elisângela Frota Anna Gabriela Rezende Santos Anna Gabriela Rezende Santos Maria Eduarda Leão Farias Maria Gabriela Almeida Rodrigues Maria Gabriela Almeida Rodrigues Bernardo Maia Silva Bernardo Maia Silva Christiane Maria Prado Jeronimo Christiane Maria Prado Jeronimo Rebeca Linhares Abreu Netto Rebeca Linhares Abreu Netto Mayla Gabriela Silva Borba Mayla Gabriela Silva Borba Djane Baía-da-Silva Djane Baía-da-Silva José Diego Brito-Sousa José Diego Brito-Sousa Mariana Simão Xavier Marcia Almeida Araújo-Alexandre Vanderson Souza Sampaio Vanderson Souza Sampaio Vanderson Souza Sampaio Gisely Cardoso Melo Gisely Cardoso Melo Guilherme Tinoco Arêas Ludhmila Abrahão Hajjar Wuelton Marcelo Monteiro Wuelton Marcelo Monteiro Felipe Gomes Naveca Fábio Trindade Maranhão Costa Fernando Fonseca Almeida Val Fernando Fonseca Almeida Val Fernando Fonseca Almeida Val Marcus Vinícius Guimarães Lacerda Marcus Vinícius Guimarães Lacerda Marcus Vinícius Guimarães Lacerda The Metcovid team Adria de Lemos Vasconcelos Adriana Ferreira Praia Marins Alexandre de Oliveira Trindade Aline Sales Mendes Záu Amanda Carvalho de Oliveira Ana Carolina Azevedo Furtado Ana Paula Coelho Rocha Anderson da Silva Souza Andiana de Souza Dias Aníbal Belém Antonny Michael da Silva Sousa Beatriz França da Silva Beatriz Leitão Franco Bleno Leonam Gonçalves da Costa Carla C. Judice Carlos Eduardo Padron de Morais Danielle Severino Sena da Silva Debora Camila Gomes Duarte Ejandre Garcia Negreiros da Silva Elias da Silva Lemos Elizandra Freitas do Nascimento Elson Silva de Almeida Elyana Almeida Marques Emanuel Medeiros Marinho de Almeida Emanuelle Lira da Silva Ester Galvão dos Santos Ezequiel da Silva Oliveira Fábio Manabu Martins Shimizu Fabíola Ramalho Ferreira de Souza Felipe da Silva do Vale Fernanda dos Santos de Almeida Lima Fernando Hugo Jesus da Fonseca Flávia Alencar Fontenelle Francielen de Azevedo Furtado Gabrielle Da Silva Pereira Geísa Aleixo Bezerra Guilherme Kemeron Maciel Salazar Handerson da Silva Pereira Hilda Ferreira de Melo Ingrid Nascimento Oliveira Ivanildo Vieira Pereira Filho Jaily e Silva Rosa Jacimara Vasques Gomes Jonas Mota Lemos Josué Nélio Brutus Karina Pinheiro Pessoa Laleyska Deucylane Costa Rodrigues Larissa Esthefani Barros Cirino Lauro Fragata Mourão Filho Leandro Moura Lorenna Pereira de Souza Lucas Barbosa Oliveira Marcela Menezes dos Santos Marcus Vinicius Ramos da Silva Mauro Pereira Rodrigues Mayara Tavares de Menezes Micaela Maciel dos Santos Mota Nadya Fonseca Corrêa Najara Bittencourt Nagila Morais Rocha Natália Guedes de Melo Silva Priscilla de Oliveira Saraiva Quézia de Sousa Monteiro Rafael Theodoro dos Santos Rebecca Augusta de Araújo Pinto Rodrigo Saboia de Lima Reinan Brotas Ferreira Rosângela Francisca Tanantas de Melo Sabrina Teixeira Saenz Salete Sara Alvarez Fernandes Sheila Vítor-Silva Thalie Cavalcante Santos Tânia Maria Rodrigues de Oliveira Tatyana A. Tavella Thais Tavares Câmara Thiago Serrão Pinto Tilza Waleska Rocha dos Santos Valdinete Alves do Nascimento Wanessa Pessoa Sousa Barbosa Wellinthon Ferreira de Melo Wlademir Braga Salgad Sobrinho
author_sort	Camila Miriam Suemi Sato Barros
title	Short-Course of Methylprednisolone Improves Respiratory Functional Parameters After 120 Days in Hospitalized COVID-19 Patients (Metcovid Trial): A Randomized Clinical Trial
title_short	Short-Course of Methylprednisolone Improves Respiratory Functional Parameters After 120 Days in Hospitalized COVID-19 Patients (Metcovid Trial): A Randomized Clinical Trial
title_full	Short-Course of Methylprednisolone Improves Respiratory Functional Parameters After 120 Days in Hospitalized COVID-19 Patients (Metcovid Trial): A Randomized Clinical Trial
title_fullStr	Short-Course of Methylprednisolone Improves Respiratory Functional Parameters After 120 Days in Hospitalized COVID-19 Patients (Metcovid Trial): A Randomized Clinical Trial
title_full_unstemmed	Short-Course of Methylprednisolone Improves Respiratory Functional Parameters After 120 Days in Hospitalized COVID-19 Patients (Metcovid Trial): A Randomized Clinical Trial
title_sort	short-course of methylprednisolone improves respiratory functional parameters after 120 days in hospitalized covid-19 patients (metcovid trial): a randomized clinical trial
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/eefc9d7a28cf4f8e89be2a8b74039465
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spelling	oai:doaj.org-article:eefc9d7a28cf4f8e89be2a8b740394652021-12-01T16:41:10ZShort-Course of Methylprednisolone Improves Respiratory Functional Parameters After 120 Days in Hospitalized COVID-19 Patients (Metcovid Trial): A Randomized Clinical Trial2296-858X10.3389/fmed.2021.758405https://doaj.org/article/eefc9d7a28cf4f8e89be2a8b740394652021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.758405/fullhttps://doaj.org/toc/2296-858XBackground: The use of corticosteroids may help control the cytokine storm occurring in acute respiratory failure due to the severe form of COVID-19. We evaluated the postacute effect of corticosteroids used during the acute phase, such as impairment in pulmonary function parameters, on day 120 (D120)-follow-up, in participants who survived over 28 days.Methods: This is a parallel, double-blind, randomized, placebo-controlled phase IIb clinical trial carried out between April 18 and October 9, 2020, conducted in hospitalized patients with clinical–radiological suspicion of COVID-19, aged 18 years or older, with SpO2 ≤ 94% on room air or requiring supplementary oxygen, or under invasive mechanical ventilation (IMV) in a referral center in Manaus, Western Brazilian Amazon. Intravenous methylprednisolone (MP) (0.5 mg/kg) was given two times daily for 5 days to these patients. The primary outcome used for this study was pulmonary function testing at day 120 follow-up visit.Results: Out of the total of surviving patients at day 28 (n = 246) from the Metcovid study, a total of 118 underwent satisfactory pulmonary function testing (62 in the placebo arm and 56 in the MP arm). The supportive treatment was similar between the placebo and MP groups (seven [11%] vs. four [7%]; P = 0.45). At hospital admission, IL-6 levels were higher in the MP group (P < 0.01). Also, the need for ICU (P = 0.06), need for IMV (P = 0.07), and creatine kinase (P = 0.05) on admission also tended to be higher in this group. In the univariate analysis, forced expiratory volume on 1st second of exhalation (FEV1) and forced vital capacity (FVC) at D120 follow-up were significantly higher in patients in the MP arm, being this last parameter also significantly higher in the multivariate analysis independently of IMV and IL-6 levels on admission.Conclusion: The use of steroids for at least 5 days in severe COVID-19 was associated with a higher FVC, which suggests that hospitalized COVID-19 patients might benefit from the use of MP in its use in the long-term, with less pulmonary restrictive functions, attributed to fibrosis.Trial Registration:ClinicalTrials.gov, Identifier: NCT04343729.Camila Miriam Suemi Sato BarrosCamila Miriam Suemi Sato BarrosRaissa Soares FreireRaissa Soares FreireElisângela FrotaElisângela FrotaAnna Gabriela Rezende SantosAnna Gabriela Rezende SantosMaria Eduarda Leão FariasMaria Gabriela Almeida RodriguesMaria Gabriela Almeida RodriguesBernardo Maia SilvaBernardo Maia SilvaChristiane Maria Prado JeronimoChristiane Maria Prado JeronimoRebeca Linhares Abreu NettoRebeca Linhares Abreu NettoMayla Gabriela Silva BorbaMayla Gabriela Silva BorbaDjane Baía-da-SilvaDjane Baía-da-SilvaJosé Diego Brito-SousaJosé Diego Brito-SousaMariana Simão XavierMarcia Almeida Araújo-AlexandreVanderson Souza SampaioVanderson Souza SampaioVanderson Souza SampaioGisely Cardoso MeloGisely Cardoso MeloGuilherme Tinoco ArêasLudhmila Abrahão HajjarWuelton Marcelo MonteiroWuelton Marcelo MonteiroFelipe Gomes NavecaFábio Trindade Maranhão CostaFernando Fonseca Almeida ValFernando Fonseca Almeida ValFernando Fonseca Almeida ValMarcus Vinícius Guimarães LacerdaMarcus Vinícius Guimarães LacerdaMarcus Vinícius Guimarães LacerdaThe Metcovid teamAdria de Lemos VasconcelosAdriana Ferreira Praia MarinsAlexandre de Oliveira TrindadeAline Sales Mendes ZáuAmanda Carvalho de OliveiraAna Carolina Azevedo FurtadoAna Paula Coelho RochaAnderson da Silva SouzaAndiana de Souza DiasAníbal BelémAntonny Michael da Silva SousaBeatriz França da SilvaBeatriz Leitão FrancoBleno Leonam Gonçalves da CostaCarla C. JudiceCarlos Eduardo Padron de MoraisDanielle Severino Sena da SilvaDebora Camila Gomes DuarteEjandre Garcia Negreiros da SilvaElias da Silva LemosElizandra Freitas do NascimentoElson Silva de AlmeidaElyana Almeida MarquesEmanuel Medeiros Marinho de AlmeidaEmanuelle Lira da SilvaEster Galvão dos SantosEzequiel da Silva OliveiraFábio Manabu Martins ShimizuFabíola Ramalho Ferreira de SouzaFelipe da Silva do ValeFernanda dos Santos de Almeida LimaFernando Hugo Jesus da FonsecaFlávia Alencar FontenelleFrancielen de Azevedo FurtadoGabrielle Da Silva PereiraGeísa Aleixo BezerraGuilherme Kemeron Maciel SalazarHanderson da Silva PereiraHilda Ferreira de MeloIngrid Nascimento OliveiraIvanildo Vieira Pereira FilhoJaily e Silva RosaJacimara Vasques GomesJonas Mota LemosJosué Nélio BrutusKarina Pinheiro PessoaLaleyska Deucylane Costa RodriguesLarissa Esthefani Barros CirinoLauro Fragata Mourão FilhoLeandro MouraLorenna Pereira de SouzaLucas Barbosa OliveiraMarcela Menezes dos SantosMarcus Vinicius Ramos da SilvaMauro Pereira RodriguesMayara Tavares de MenezesMicaela Maciel dos Santos MotaNadya Fonseca CorrêaNajara BittencourtNagila Morais RochaNatália Guedes de Melo SilvaPriscilla de Oliveira SaraivaQuézia de Sousa MonteiroRafael Theodoro dos SantosRebecca Augusta de Araújo PintoRodrigo Saboia de Lima Reinan Brotas FerreiraRosângela Francisca Tanantas de MeloSabrina Teixeira SaenzSalete Sara Alvarez FernandesSheila Vítor-SilvaThalie Cavalcante SantosTânia Maria Rodrigues de OliveiraTatyana A. TavellaThais Tavares CâmaraThiago Serrão PintoTilza Waleska Rocha dos SantosValdinete Alves do NascimentoWanessa Pessoa Sousa BarbosaWellinthon Ferreira de MeloWlademir Braga Salgad SobrinhoFrontiers Media S.A.articleSARS-CoV-2COVID-19pulmonary function testlong-covidcorticosteroidinflammationMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)

Short-Course of Methylprednisolone Improves Respiratory Functional Parameters After 120 Days in Hospitalized COVID-19 Patients (Metcovid Trial): A Randomized Clinical Trial

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