Self-organized intestinal epithelial monolayers in crypt and villus-like domains show effective barrier function

Abstract Intestinal organoids have emerged as a powerful in vitro tool for studying intestinal biology due to their resemblance to in vivo tissue at the structural and functional levels. However, their sphere-like geometry prevents access to the apical side of the epithelium, making them unsuitable...

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Bibliographic Details
Main Authors: Gizem Altay, Enara Larrañaga, Sébastien Tosi, Francisco M. Barriga, Eduard Batlle, Vanesa Fernández-Majada, Elena Martínez
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
R
Q
Online Access:https://doaj.org/article/eefe1a4a21a2472280147542e31a1d4d
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