GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis

GPRC5A is a retinoic acid inducible gene that is preferentially expressed in lung tissue. Here the authors report that GPRC5A suppresses the translation of EGFR by interfering with the eIF4F complex assembly, thereby limiting lung tumorigenesis, particularly radiation-induced lung tumorigenesis.

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Detalles Bibliográficos
Autores principales:	Jian Wang, Alton B. Farris, Kaiming Xu, Ping Wang, Xiangming Zhang, Duc M. Duong, Hong Yi, Hui-Kuo Shu, Shi-Yong Sun, Ya Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eefed085ba1e4e39ac211c89a889211e
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spelling	oai:doaj.org-article:eefed085ba1e4e39ac211c89a889211e2021-12-02T16:57:05ZGPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis10.1038/ncomms117952041-1723https://doaj.org/article/eefed085ba1e4e39ac211c89a889211e2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11795https://doaj.org/toc/2041-1723GPRC5A is a retinoic acid inducible gene that is preferentially expressed in lung tissue. Here the authors report that GPRC5A suppresses the translation of EGFR by interfering with the eIF4F complex assembly, thereby limiting lung tumorigenesis, particularly radiation-induced lung tumorigenesis.Jian WangAlton B. FarrisKaiming XuPing WangXiangming ZhangDuc M. DuongHong YiHui-Kuo ShuShi-Yong SunYa WangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jian Wang Alton B. Farris Kaiming Xu Ping Wang Xiangming Zhang Duc M. Duong Hong Yi Hui-Kuo Shu Shi-Yong Sun Ya Wang GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis
description	GPRC5A is a retinoic acid inducible gene that is preferentially expressed in lung tissue. Here the authors report that GPRC5A suppresses the translation of EGFR by interfering with the eIF4F complex assembly, thereby limiting lung tumorigenesis, particularly radiation-induced lung tumorigenesis.
format	article
author	Jian Wang Alton B. Farris Kaiming Xu Ping Wang Xiangming Zhang Duc M. Duong Hong Yi Hui-Kuo Shu Shi-Yong Sun Ya Wang
author_facet	Jian Wang Alton B. Farris Kaiming Xu Ping Wang Xiangming Zhang Duc M. Duong Hong Yi Hui-Kuo Shu Shi-Yong Sun Ya Wang
author_sort	Jian Wang
title	GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis
title_short	GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis
title_full	GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis
title_fullStr	GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis
title_full_unstemmed	GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis
title_sort	gprc5a suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/eefed085ba1e4e39ac211c89a889211e
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GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis

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