The PINK1-Parkin mitophagy signalling pathway is not functional in peripheral blood mononuclear cells.

The PINK1-Parkin mitophagy signalling pathway is not functional in peripheral blood mononuclear cells.

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Mutations in the PINK1 and PRKN genes are the most common cause of early-onset familial Parkinson disease. These genes code for the PINK1 and Parkin proteins, respectively, which are involved in the degradation of dysfunctional mitochondria through mitophagy. An early step in PINK1 -Parkin mediated...

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Bibliographic Details
Main Authors: Aaron V Bradshaw, Philip Campbell, Anthony H V Schapira, Huw R Morris, Jan-Willem Taanman
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2021
Subjects:
Medicine
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Science
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Online Access:https://doaj.org/article/eeff75a814d547dbb23eb3bac39dd8ce
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