Human breast tumor-infiltrating CD8+ T cells retain polyfunctionality despite PD-1 expression

Expression of the checkpoint molecule programmed cell death protein 1 (PD-1) is considered a marker of T cells exhaustion. Here the authors show that CD8T cells isolated from breast cancer patients are perfectly functional despite PD-1 expression while those isolated from melanoma patients are not.

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Autores principales:	Colt A. Egelston, Christian Avalos, Travis Y. Tu, Diana L. Simons, Grecia Jimenez, Jae Y. Jung, Laleh Melstrom, Kim Margolin, John H. Yim, Laura Kruper, Joanne Mortimer, Peter P. Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ef04fd0226fd442ea943ccda7d8a10a5
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spelling	oai:doaj.org-article:ef04fd0226fd442ea943ccda7d8a10a52021-12-02T16:56:37ZHuman breast tumor-infiltrating CD8+ T cells retain polyfunctionality despite PD-1 expression10.1038/s41467-018-06653-92041-1723https://doaj.org/article/ef04fd0226fd442ea943ccda7d8a10a52018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06653-9https://doaj.org/toc/2041-1723Expression of the checkpoint molecule programmed cell death protein 1 (PD-1) is considered a marker of T cells exhaustion. Here the authors show that CD8T cells isolated from breast cancer patients are perfectly functional despite PD-1 expression while those isolated from melanoma patients are not.Colt A. EgelstonChristian AvalosTravis Y. TuDiana L. SimonsGrecia JimenezJae Y. JungLaleh MelstromKim MargolinJohn H. YimLaura KruperJoanne MortimerPeter P. LeeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Colt A. Egelston Christian Avalos Travis Y. Tu Diana L. Simons Grecia Jimenez Jae Y. Jung Laleh Melstrom Kim Margolin John H. Yim Laura Kruper Joanne Mortimer Peter P. Lee Human breast tumor-infiltrating CD8+ T cells retain polyfunctionality despite PD-1 expression
description	Expression of the checkpoint molecule programmed cell death protein 1 (PD-1) is considered a marker of T cells exhaustion. Here the authors show that CD8T cells isolated from breast cancer patients are perfectly functional despite PD-1 expression while those isolated from melanoma patients are not.
format	article
author	Colt A. Egelston Christian Avalos Travis Y. Tu Diana L. Simons Grecia Jimenez Jae Y. Jung Laleh Melstrom Kim Margolin John H. Yim Laura Kruper Joanne Mortimer Peter P. Lee
author_facet	Colt A. Egelston Christian Avalos Travis Y. Tu Diana L. Simons Grecia Jimenez Jae Y. Jung Laleh Melstrom Kim Margolin John H. Yim Laura Kruper Joanne Mortimer Peter P. Lee
author_sort	Colt A. Egelston
title	Human breast tumor-infiltrating CD8+ T cells retain polyfunctionality despite PD-1 expression
title_short	Human breast tumor-infiltrating CD8+ T cells retain polyfunctionality despite PD-1 expression
title_full	Human breast tumor-infiltrating CD8+ T cells retain polyfunctionality despite PD-1 expression
title_fullStr	Human breast tumor-infiltrating CD8+ T cells retain polyfunctionality despite PD-1 expression
title_full_unstemmed	Human breast tumor-infiltrating CD8+ T cells retain polyfunctionality despite PD-1 expression
title_sort	human breast tumor-infiltrating cd8+ t cells retain polyfunctionality despite pd-1 expression
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ef04fd0226fd442ea943ccda7d8a10a5
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Human breast tumor-infiltrating CD8+ T cells retain polyfunctionality despite PD-1 expression

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