Human breast tumor-infiltrating CD8+ T cells retain polyfunctionality despite PD-1 expression

Expression of the checkpoint molecule programmed cell death protein 1 (PD-1) is considered a marker of T cells exhaustion. Here the authors show that CD8T cells isolated from breast cancer patients are perfectly functional despite PD-1 expression while those isolated from melanoma patients are not.

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Colt A. Egelston, Christian Avalos, Travis Y. Tu, Diana L. Simons, Grecia Jimenez, Jae Y. Jung, Laleh Melstrom, Kim Margolin, John H. Yim, Laura Kruper, Joanne Mortimer, Peter P. Lee
Format: article
Langue:EN
Publié: Nature Portfolio 2018
Sujets:
Q
Accès en ligne:https://doaj.org/article/ef04fd0226fd442ea943ccda7d8a10a5
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!