Patterns of Migraine in Postmenopausal Women: A Systematic Review

Raffaele Ornello,1 Valeria Caponnetto,1 Ilaria Frattale,2 Simona Sacco1 1Department of Applied Clinical Sciences and Biotechnology, University of L’Aquila, L’Aquila, Italy; 2Child Neurology and Psychiatry Unit, Systems Medicine Department, Tor Vergata University, Rome, ItalyCorre...

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Autores principales:	Ornello R, Caponnetto V, Frattale I, Sacco S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	migraine menopause systematic review hormone replacement treatment Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/ef075d56019946dda1c5601f6cd82da4
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spelling	oai:doaj.org-article:ef075d56019946dda1c5601f6cd82da42021-12-02T16:31:09ZPatterns of Migraine in Postmenopausal Women: A Systematic Review1178-2021https://doaj.org/article/ef075d56019946dda1c5601f6cd82da42021-03-01T00:00:00Zhttps://www.dovepress.com/patterns-of-migraine-in-postmenopausal-women-a-systematic-review-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Raffaele Ornello,1 Valeria Caponnetto,1 Ilaria Frattale,2 Simona Sacco1 1Department of Applied Clinical Sciences and Biotechnology, University of L’Aquila, L’Aquila, Italy; 2Child Neurology and Psychiatry Unit, Systems Medicine Department, Tor Vergata University, Rome, ItalyCorrespondence: Raffaele OrnelloDepartment of Applied Clinical Sciences and Biotechnology, University of L’Aquila, L’Aquila, ItalyTel +393288756932Fax +390862433561Email raffaele.ornello@gmail.comIntroduction: Migraine prevalence is higher in fertile than in postmenopausal women. However, few literature data are available on the prevalence and characteristics of migraine after the menopause and on the effect of hormones in postmenopausal women with migraine.Methods: We performed a systematic literature review of studies available on Scopus and Web of Science from the beginning off indexing until October 18th, 2020. We included both randomized trials and observational studies.Results: We included 12 papers, six of which assessed the prevalence and characteristics of migraine in postmenopausal women, while the other six assessed the effect of hormones on migraine after the menopause. One of the studies was a randomized trial, while the remaining 11 were observational studies. Ten studies were clinic-based, while the remaining two were population-based. Studies assessing the prevalence and characteristics of migraine after the menopause reported inconsistent findings; in studies performed in headache clinics, likely affected by selection bias towards the most severe cases, a relevant proportion of women reported migraine worsening after the menopause. Studies assessing the effect of hormones on migraine after the menopause showed that postmenopausal hormone replacement therapy was invariably associated with migraine worsening, if containing estrogen.Conclusion: Our systematic review showed that migraine could be a relevant health problem in postmenopausal women, mostly in headache clinics. However, the available studies allow a limited assessment of the prevalence and characteristics of postmenopausal migraine. Further large studies are needed to better determine the burden of migraine after the menopause according to migraine characteristics and the impact of hormonal treatments.Keywords: migraine, menopause, systematic review, hormone replacement treatmentOrnello RCaponnetto VFrattale ISacco SDove Medical Pressarticlemigrainemenopausesystematic reviewhormone replacement treatmentNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 859-871 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	migraine menopause systematic review hormone replacement treatment Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	migraine menopause systematic review hormone replacement treatment Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Ornello R Caponnetto V Frattale I Sacco S Patterns of Migraine in Postmenopausal Women: A Systematic Review
description	Raffaele Ornello,1 Valeria Caponnetto,1 Ilaria Frattale,2 Simona Sacco1 1Department of Applied Clinical Sciences and Biotechnology, University of L’Aquila, L’Aquila, Italy; 2Child Neurology and Psychiatry Unit, Systems Medicine Department, Tor Vergata University, Rome, ItalyCorrespondence: Raffaele OrnelloDepartment of Applied Clinical Sciences and Biotechnology, University of L’Aquila, L’Aquila, ItalyTel +393288756932Fax +390862433561Email raffaele.ornello@gmail.comIntroduction: Migraine prevalence is higher in fertile than in postmenopausal women. However, few literature data are available on the prevalence and characteristics of migraine after the menopause and on the effect of hormones in postmenopausal women with migraine.Methods: We performed a systematic literature review of studies available on Scopus and Web of Science from the beginning off indexing until October 18th, 2020. We included both randomized trials and observational studies.Results: We included 12 papers, six of which assessed the prevalence and characteristics of migraine in postmenopausal women, while the other six assessed the effect of hormones on migraine after the menopause. One of the studies was a randomized trial, while the remaining 11 were observational studies. Ten studies were clinic-based, while the remaining two were population-based. Studies assessing the prevalence and characteristics of migraine after the menopause reported inconsistent findings; in studies performed in headache clinics, likely affected by selection bias towards the most severe cases, a relevant proportion of women reported migraine worsening after the menopause. Studies assessing the effect of hormones on migraine after the menopause showed that postmenopausal hormone replacement therapy was invariably associated with migraine worsening, if containing estrogen.Conclusion: Our systematic review showed that migraine could be a relevant health problem in postmenopausal women, mostly in headache clinics. However, the available studies allow a limited assessment of the prevalence and characteristics of postmenopausal migraine. Further large studies are needed to better determine the burden of migraine after the menopause according to migraine characteristics and the impact of hormonal treatments.Keywords: migraine, menopause, systematic review, hormone replacement treatment
format	article
author	Ornello R Caponnetto V Frattale I Sacco S
author_facet	Ornello R Caponnetto V Frattale I Sacco S
author_sort	Ornello R
title	Patterns of Migraine in Postmenopausal Women: A Systematic Review
title_short	Patterns of Migraine in Postmenopausal Women: A Systematic Review
title_full	Patterns of Migraine in Postmenopausal Women: A Systematic Review
title_fullStr	Patterns of Migraine in Postmenopausal Women: A Systematic Review
title_full_unstemmed	Patterns of Migraine in Postmenopausal Women: A Systematic Review
title_sort	patterns of migraine in postmenopausal women: a systematic review
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/ef075d56019946dda1c5601f6cd82da4
work_keys_str_mv	AT ornellor patternsofmigraineinpostmenopausalwomenasystematicreview AT caponnettov patternsofmigraineinpostmenopausalwomenasystematicreview AT frattalei patternsofmigraineinpostmenopausalwomenasystematicreview AT saccos patternsofmigraineinpostmenopausalwomenasystematicreview
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Patterns of Migraine in Postmenopausal Women: A Systematic Review

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