Identification of prognostic biomarkers related to the tumor microenvironment in thyroid carcinoma

Abstract Thyroid Carcinoma (THCA) is the most common endocrine tumor that is mainly treated using surgery and radiotherapy. In addition, immunotherapy is a recently developed treatment option that has played an essential role in the management of several types of tumors. However, few reports exist o...

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Autores principales:	Jun-wei Du, Guo-quan Li, Yang-sen Li, Xin-guang Qiu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ef0a8cd04d844a71986dcab06bdf3c58
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spelling	oai:doaj.org-article:ef0a8cd04d844a71986dcab06bdf3c582021-12-02T16:27:44ZIdentification of prognostic biomarkers related to the tumor microenvironment in thyroid carcinoma10.1038/s41598-021-90538-32045-2322https://doaj.org/article/ef0a8cd04d844a71986dcab06bdf3c582021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90538-3https://doaj.org/toc/2045-2322Abstract Thyroid Carcinoma (THCA) is the most common endocrine tumor that is mainly treated using surgery and radiotherapy. In addition, immunotherapy is a recently developed treatment option that has played an essential role in the management of several types of tumors. However, few reports exist on the use of immunotherapy to treat THCA. The study downloaded the miRNA, mRNA and lncRNA data for THCA patients from the TCGA database ( https://portal.gdc.cancer.gov/ ). Thereafter, the tumor samples were divided into cold and hot tumors, based on the immune score of the tumor microenvironment. Moreover, the differentially expressed lncRNAs and miRNAs were obtained. Finally, the study jointly constructed a ceRNA network through differential analysis of the mRNA data for cold and hot tumors. The study first assessed the level of immune infiltration in the THCA tumor microenvironment then divided the samples into cold and hot tumors, based on the immune score. Additionally, a total of 568 up-regulated and 412 down-regulated DEGs were screened by analyzing the differences between hot and cold tumors. Thereafter, the study examined the differentially expressed genes for lncRNA and miRNA. The results revealed 629 differentially expressed genes related to lncRNA and 114 associated with miRNA. Finally, a ceRNA network of the differentially expressed genes was constructed. The results showed a five-miRNA hubnet, i.e., hsa-mir-204, hsa-mir-128, hsa-mir-214, hsa-mir-150 and hsa-mir-338. The present study identified the immune-related mRNA, lncRNA and miRNA in THCA then constructed a ceRNA network. These results are therefore important as they provide more insights on the immune mechanisms in THCA. The findings also provides additional information for possible THCA immunotherapy.Jun-wei DuGuo-quan LiYang-sen LiXin-guang QiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jun-wei Du Guo-quan Li Yang-sen Li Xin-guang Qiu Identification of prognostic biomarkers related to the tumor microenvironment in thyroid carcinoma
description	Abstract Thyroid Carcinoma (THCA) is the most common endocrine tumor that is mainly treated using surgery and radiotherapy. In addition, immunotherapy is a recently developed treatment option that has played an essential role in the management of several types of tumors. However, few reports exist on the use of immunotherapy to treat THCA. The study downloaded the miRNA, mRNA and lncRNA data for THCA patients from the TCGA database ( https://portal.gdc.cancer.gov/ ). Thereafter, the tumor samples were divided into cold and hot tumors, based on the immune score of the tumor microenvironment. Moreover, the differentially expressed lncRNAs and miRNAs were obtained. Finally, the study jointly constructed a ceRNA network through differential analysis of the mRNA data for cold and hot tumors. The study first assessed the level of immune infiltration in the THCA tumor microenvironment then divided the samples into cold and hot tumors, based on the immune score. Additionally, a total of 568 up-regulated and 412 down-regulated DEGs were screened by analyzing the differences between hot and cold tumors. Thereafter, the study examined the differentially expressed genes for lncRNA and miRNA. The results revealed 629 differentially expressed genes related to lncRNA and 114 associated with miRNA. Finally, a ceRNA network of the differentially expressed genes was constructed. The results showed a five-miRNA hubnet, i.e., hsa-mir-204, hsa-mir-128, hsa-mir-214, hsa-mir-150 and hsa-mir-338. The present study identified the immune-related mRNA, lncRNA and miRNA in THCA then constructed a ceRNA network. These results are therefore important as they provide more insights on the immune mechanisms in THCA. The findings also provides additional information for possible THCA immunotherapy.
format	article
author	Jun-wei Du Guo-quan Li Yang-sen Li Xin-guang Qiu
author_facet	Jun-wei Du Guo-quan Li Yang-sen Li Xin-guang Qiu
author_sort	Jun-wei Du
title	Identification of prognostic biomarkers related to the tumor microenvironment in thyroid carcinoma
title_short	Identification of prognostic biomarkers related to the tumor microenvironment in thyroid carcinoma
title_full	Identification of prognostic biomarkers related to the tumor microenvironment in thyroid carcinoma
title_fullStr	Identification of prognostic biomarkers related to the tumor microenvironment in thyroid carcinoma
title_full_unstemmed	Identification of prognostic biomarkers related to the tumor microenvironment in thyroid carcinoma
title_sort	identification of prognostic biomarkers related to the tumor microenvironment in thyroid carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ef0a8cd04d844a71986dcab06bdf3c58
work_keys_str_mv	AT junweidu identificationofprognosticbiomarkersrelatedtothetumormicroenvironmentinthyroidcarcinoma AT guoquanli identificationofprognosticbiomarkersrelatedtothetumormicroenvironmentinthyroidcarcinoma AT yangsenli identificationofprognosticbiomarkersrelatedtothetumormicroenvironmentinthyroidcarcinoma AT xinguangqiu identificationofprognosticbiomarkersrelatedtothetumormicroenvironmentinthyroidcarcinoma
_version_	1718384027129348096

Identification of prognostic biomarkers related to the tumor microenvironment in thyroid carcinoma

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