Ultrasmall PEI-Decorated Bi2Se3 Nanodots as a Multifunctional Theranostic Nanoplatform for in vivo CT Imaging-Guided Cancer Photothermal Therapy

Bi-based nanomaterials, such as Bi2Se3, play an important part in biomedicine, such as photothermal therapy (PTT) and computed tomography (CT) imaging. Polyethylenimine (PEI)-modified ultrasmall Bi2Se3 nanodots were prepared using an ultrafast synthetic method at room temperature (25°C). Bi2Se3 nano...

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Autores principales:	Peng Zhang, Lei Wang, Xiuying Chen, Xiang Li, Qinghai Yuan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	photothermal therapy Bi2Se3 nanodots ultrafast synthesis CT imaging cancer therapy Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/ef0afb4978d044b7977e8e8c7ad80802
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spelling	oai:doaj.org-article:ef0afb4978d044b7977e8e8c7ad808022021-12-02T11:30:21ZUltrasmall PEI-Decorated Bi2Se3 Nanodots as a Multifunctional Theranostic Nanoplatform for in vivo CT Imaging-Guided Cancer Photothermal Therapy1663-981210.3389/fphar.2021.795012https://doaj.org/article/ef0afb4978d044b7977e8e8c7ad808022021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.795012/fullhttps://doaj.org/toc/1663-9812Bi-based nanomaterials, such as Bi2Se3, play an important part in biomedicine, such as photothermal therapy (PTT) and computed tomography (CT) imaging. Polyethylenimine (PEI)-modified ultrasmall Bi2Se3 nanodots were prepared using an ultrafast synthetic method at room temperature (25°C). Bi2Se3 nanodots exhibited superior CT imaging performance, and could be used as effective photothermal reagents owing to their broad absorption in the ultraviolet–visible–near infrared region. Under irradiation at 808 nm, PEI-Bi2Se3 nanodots exhibited excellent photothermal-conversion efficiency of up to 41.3%. Good biocompatibility and significant tumor-ablation capabilities were demonstrated in vitro and in vivo. These results revealed that PEI-Bi2Se3 nanodots are safe and a good nanotheranostic platform for CT imaging-guided PTT of cancer.Peng ZhangLei WangXiuying ChenXiang LiQinghai YuanFrontiers Media S.A.articlephotothermal therapyBi2Se3 nanodotsultrafast synthesisCT imagingcancer therapyTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	photothermal therapy Bi2Se3 nanodots ultrafast synthesis CT imaging cancer therapy Therapeutics. Pharmacology RM1-950
spellingShingle	photothermal therapy Bi2Se3 nanodots ultrafast synthesis CT imaging cancer therapy Therapeutics. Pharmacology RM1-950 Peng Zhang Lei Wang Xiuying Chen Xiang Li Qinghai Yuan Ultrasmall PEI-Decorated Bi2Se3 Nanodots as a Multifunctional Theranostic Nanoplatform for in vivo CT Imaging-Guided Cancer Photothermal Therapy
description	Bi-based nanomaterials, such as Bi2Se3, play an important part in biomedicine, such as photothermal therapy (PTT) and computed tomography (CT) imaging. Polyethylenimine (PEI)-modified ultrasmall Bi2Se3 nanodots were prepared using an ultrafast synthetic method at room temperature (25°C). Bi2Se3 nanodots exhibited superior CT imaging performance, and could be used as effective photothermal reagents owing to their broad absorption in the ultraviolet–visible–near infrared region. Under irradiation at 808 nm, PEI-Bi2Se3 nanodots exhibited excellent photothermal-conversion efficiency of up to 41.3%. Good biocompatibility and significant tumor-ablation capabilities were demonstrated in vitro and in vivo. These results revealed that PEI-Bi2Se3 nanodots are safe and a good nanotheranostic platform for CT imaging-guided PTT of cancer.
format	article
author	Peng Zhang Lei Wang Xiuying Chen Xiang Li Qinghai Yuan
author_facet	Peng Zhang Lei Wang Xiuying Chen Xiang Li Qinghai Yuan
author_sort	Peng Zhang
title	Ultrasmall PEI-Decorated Bi2Se3 Nanodots as a Multifunctional Theranostic Nanoplatform for in vivo CT Imaging-Guided Cancer Photothermal Therapy
title_short	Ultrasmall PEI-Decorated Bi2Se3 Nanodots as a Multifunctional Theranostic Nanoplatform for in vivo CT Imaging-Guided Cancer Photothermal Therapy
title_full	Ultrasmall PEI-Decorated Bi2Se3 Nanodots as a Multifunctional Theranostic Nanoplatform for in vivo CT Imaging-Guided Cancer Photothermal Therapy
title_fullStr	Ultrasmall PEI-Decorated Bi2Se3 Nanodots as a Multifunctional Theranostic Nanoplatform for in vivo CT Imaging-Guided Cancer Photothermal Therapy
title_full_unstemmed	Ultrasmall PEI-Decorated Bi2Se3 Nanodots as a Multifunctional Theranostic Nanoplatform for in vivo CT Imaging-Guided Cancer Photothermal Therapy
title_sort	ultrasmall pei-decorated bi2se3 nanodots as a multifunctional theranostic nanoplatform for in vivo ct imaging-guided cancer photothermal therapy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ef0afb4978d044b7977e8e8c7ad80802
work_keys_str_mv	AT pengzhang ultrasmallpeidecoratedbi2se3nanodotsasamultifunctionaltheranosticnanoplatformforinvivoctimagingguidedcancerphotothermaltherapy AT leiwang ultrasmallpeidecoratedbi2se3nanodotsasamultifunctionaltheranosticnanoplatformforinvivoctimagingguidedcancerphotothermaltherapy AT xiuyingchen ultrasmallpeidecoratedbi2se3nanodotsasamultifunctionaltheranosticnanoplatformforinvivoctimagingguidedcancerphotothermaltherapy AT xiangli ultrasmallpeidecoratedbi2se3nanodotsasamultifunctionaltheranosticnanoplatformforinvivoctimagingguidedcancerphotothermaltherapy AT qinghaiyuan ultrasmallpeidecoratedbi2se3nanodotsasamultifunctionaltheranosticnanoplatformforinvivoctimagingguidedcancerphotothermaltherapy
_version_	1718395913994502144

Ultrasmall PEI-Decorated Bi2Se3 Nanodots as a Multifunctional Theranostic Nanoplatform for in vivo CT Imaging-Guided Cancer Photothermal Therapy

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