The possible role of molecular mimicry in SARS-CoV-2-mediated autoimmunity: an immunobiochemical basis

Coronavirus Disease 2019 (COVID-19), caused by the novel Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), persists as a threat to global health and continues to be a rapidly evolving condition. Although COVID19 is negatively correlated with the existing comorbidities in terms of the cl...

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Autores principales:	Dženan Kovačić, Jovana Jotanović, Jasmina Laković
Formato:	article
Lenguaje:	EN
Publicado:	Poznan University of Medical Sciences 2021
Materias:	autoimmunity and COVID19 molecular mimicry and COVID19 SARS-CoV-2 autoimmunity molecular mimicry Medicine R
Acceso en línea:	https://doaj.org/article/ef0e73cb198e4f488d507c7d6f051150
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spelling	oai:doaj.org-article:ef0e73cb198e4f488d507c7d6f0511502021-11-11T08:05:30ZThe possible role of molecular mimicry in SARS-CoV-2-mediated autoimmunity: an immunobiochemical basis10.20883/medical.e5602353-97982353-9801https://doaj.org/article/ef0e73cb198e4f488d507c7d6f0511502021-10-01T00:00:00Zhttps://jms.ump.edu.pl/index.php/JMS/article/view/560https://doaj.org/toc/2353-9798https://doaj.org/toc/2353-9801 Coronavirus Disease 2019 (COVID-19), caused by the novel Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), persists as a threat to global health and continues to be a rapidly evolving condition. Although COVID19 is negatively correlated with the existing comorbidities in terms of the clinical outcome, the ability of SARS-CoV-2 to mediate the novel, or to exacerbate the existing autoimmune conditions, has generated considerable interest, due to its potential implications both with regard to patients suffering from autoimmune conditions, as well as to the long-term consequences of the disease. However, although molecular mimicry has been postulated as a potential causative factor in post-COVID19 autoimmunity and multi-organ damage, a substantial body of research needs to emerge in order to achieve a more definitive conclusion. We investigated the possibility of SARS-CoV-2 peptide sequences behaving as molecular mimics with a potential to trigger an autoimmune response. Thus, on the basis of analysis in silico, we were able to develop a plausible case for the molecular mimicry as a potential aetiological mechanism of SARS-CoV-2-mediated autoimmunity, both in a multi-organ damage context or outside of the viral phase of infection. Interestingly, this is the first time that the peptide sequence of MACROD1 has been implicated in the COVID-19 autoimmunity. Additionally, we also confirm that PARP9 and PARP14 may be involved in the process. Dženan KovačićJovana JotanovićJasmina LakovićPoznan University of Medical Sciencesarticleautoimmunity and COVID19molecular mimicry and COVID19SARS-CoV-2 autoimmunitymolecular mimicryMedicineRENJournal of Medical Science, Vol 90, Iss 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	autoimmunity and COVID19 molecular mimicry and COVID19 SARS-CoV-2 autoimmunity molecular mimicry Medicine R
spellingShingle	autoimmunity and COVID19 molecular mimicry and COVID19 SARS-CoV-2 autoimmunity molecular mimicry Medicine R Dženan Kovačić Jovana Jotanović Jasmina Laković The possible role of molecular mimicry in SARS-CoV-2-mediated autoimmunity: an immunobiochemical basis
description	Coronavirus Disease 2019 (COVID-19), caused by the novel Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), persists as a threat to global health and continues to be a rapidly evolving condition. Although COVID19 is negatively correlated with the existing comorbidities in terms of the clinical outcome, the ability of SARS-CoV-2 to mediate the novel, or to exacerbate the existing autoimmune conditions, has generated considerable interest, due to its potential implications both with regard to patients suffering from autoimmune conditions, as well as to the long-term consequences of the disease. However, although molecular mimicry has been postulated as a potential causative factor in post-COVID19 autoimmunity and multi-organ damage, a substantial body of research needs to emerge in order to achieve a more definitive conclusion. We investigated the possibility of SARS-CoV-2 peptide sequences behaving as molecular mimics with a potential to trigger an autoimmune response. Thus, on the basis of analysis in silico, we were able to develop a plausible case for the molecular mimicry as a potential aetiological mechanism of SARS-CoV-2-mediated autoimmunity, both in a multi-organ damage context or outside of the viral phase of infection. Interestingly, this is the first time that the peptide sequence of MACROD1 has been implicated in the COVID-19 autoimmunity. Additionally, we also confirm that PARP9 and PARP14 may be involved in the process.
format	article
author	Dženan Kovačić Jovana Jotanović Jasmina Laković
author_facet	Dženan Kovačić Jovana Jotanović Jasmina Laković
author_sort	Dženan Kovačić
title	The possible role of molecular mimicry in SARS-CoV-2-mediated autoimmunity: an immunobiochemical basis
title_short	The possible role of molecular mimicry in SARS-CoV-2-mediated autoimmunity: an immunobiochemical basis
title_full	The possible role of molecular mimicry in SARS-CoV-2-mediated autoimmunity: an immunobiochemical basis
title_fullStr	The possible role of molecular mimicry in SARS-CoV-2-mediated autoimmunity: an immunobiochemical basis
title_full_unstemmed	The possible role of molecular mimicry in SARS-CoV-2-mediated autoimmunity: an immunobiochemical basis
title_sort	possible role of molecular mimicry in sars-cov-2-mediated autoimmunity: an immunobiochemical basis
publisher	Poznan University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/ef0e73cb198e4f488d507c7d6f051150
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The possible role of molecular mimicry in SARS-CoV-2-mediated autoimmunity: an immunobiochemical basis

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