Entropy of a bacterial stress response is a generalizable predictor for fitness and antibiotic sensitivity

Bacterial transcriptomic data have been used to predict antibiotic susceptibility in a species- or antibiotic-specific manner. Here, the authors show that global transcriptional disorder is a common stress response in bacteria with low fitness, and present a general approach that can predict bacteri...

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Autores principales:	Zeyu Zhu, Defne Surujon, Juan C. Ortiz-Marquez, Wenwen Huo, Ralph R. Isberg, José Bento, Tim van Opijnen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ef0fe239e15245d990fc0ccfb009ce26
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spelling	oai:doaj.org-article:ef0fe239e15245d990fc0ccfb009ce262021-12-02T19:09:54ZEntropy of a bacterial stress response is a generalizable predictor for fitness and antibiotic sensitivity10.1038/s41467-020-18134-z2041-1723https://doaj.org/article/ef0fe239e15245d990fc0ccfb009ce262020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18134-zhttps://doaj.org/toc/2041-1723Bacterial transcriptomic data have been used to predict antibiotic susceptibility in a species- or antibiotic-specific manner. Here, the authors show that global transcriptional disorder is a common stress response in bacteria with low fitness, and present a general approach that can predict bacterial fitness independently of species or type of stress.Zeyu ZhuDefne SurujonJuan C. Ortiz-MarquezWenwen HuoRalph R. IsbergJosé BentoTim van OpijnenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zeyu Zhu Defne Surujon Juan C. Ortiz-Marquez Wenwen Huo Ralph R. Isberg José Bento Tim van Opijnen Entropy of a bacterial stress response is a generalizable predictor for fitness and antibiotic sensitivity
description	Bacterial transcriptomic data have been used to predict antibiotic susceptibility in a species- or antibiotic-specific manner. Here, the authors show that global transcriptional disorder is a common stress response in bacteria with low fitness, and present a general approach that can predict bacterial fitness independently of species or type of stress.
format	article
author	Zeyu Zhu Defne Surujon Juan C. Ortiz-Marquez Wenwen Huo Ralph R. Isberg José Bento Tim van Opijnen
author_facet	Zeyu Zhu Defne Surujon Juan C. Ortiz-Marquez Wenwen Huo Ralph R. Isberg José Bento Tim van Opijnen
author_sort	Zeyu Zhu
title	Entropy of a bacterial stress response is a generalizable predictor for fitness and antibiotic sensitivity
title_short	Entropy of a bacterial stress response is a generalizable predictor for fitness and antibiotic sensitivity
title_full	Entropy of a bacterial stress response is a generalizable predictor for fitness and antibiotic sensitivity
title_fullStr	Entropy of a bacterial stress response is a generalizable predictor for fitness and antibiotic sensitivity
title_full_unstemmed	Entropy of a bacterial stress response is a generalizable predictor for fitness and antibiotic sensitivity
title_sort	entropy of a bacterial stress response is a generalizable predictor for fitness and antibiotic sensitivity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ef0fe239e15245d990fc0ccfb009ce26
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Entropy of a bacterial stress response is a generalizable predictor for fitness and antibiotic sensitivity

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