The first case of acute myeloid leukaemia/myeloid sarcoma with cytokeratin expression on blasts diagnosed on urine specimen

Here we describe a rare case of renal myeloid sarcoma, first discovered incidentally on routine urine analysis, which is one of the first of it’s kind to be reported. We describe the vanishingly rare phenomenon of renal myeloid sarcoma presenting without haematological manifestation while also highl...

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Autores principales:	Claire Comerford, Sarah Ni Mhaolcatha, Brian Hayes, Vitaliy Mykytiv
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Acute myeloid leukaemia Myeloid sarcoma Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/ef1254df48044cbf8422afe510b38d0b
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spelling	oai:doaj.org-article:ef1254df48044cbf8422afe510b38d0b2021-12-02T04:59:59ZThe first case of acute myeloid leukaemia/myeloid sarcoma with cytokeratin expression on blasts diagnosed on urine specimen1658-387610.1016/j.hemonc.2020.02.007https://doaj.org/article/ef1254df48044cbf8422afe510b38d0b2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1658387620300406https://doaj.org/toc/1658-3876Here we describe a rare case of renal myeloid sarcoma, first discovered incidentally on routine urine analysis, which is one of the first of it’s kind to be reported. We describe the vanishingly rare phenomenon of renal myeloid sarcoma presenting without haematological manifestation while also highlighting the often inevitable transformative nature of the disease. We also describe the unusual immunohistochemistry findings, in particular the cytokeratin expression, that is not usually typical of such cases. We briefly discuss use of PET-CT for the disease response monitoring. We summarize treatment that has included palbociclib, use of which was previously reported only in small series of patients with AML with KMT2A mutation.Claire ComerfordSarah Ni MhaolcathaBrian HayesVitaliy MykytivElsevierarticleAcute myeloid leukaemiaMyeloid sarcomaDiseases of the blood and blood-forming organsRC633-647.5Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENHematology/Oncology and Stem Cell Therapy, Vol 14, Iss 4, Pp 343-347 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Acute myeloid leukaemia Myeloid sarcoma Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Acute myeloid leukaemia Myeloid sarcoma Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Claire Comerford Sarah Ni Mhaolcatha Brian Hayes Vitaliy Mykytiv The first case of acute myeloid leukaemia/myeloid sarcoma with cytokeratin expression on blasts diagnosed on urine specimen
description	Here we describe a rare case of renal myeloid sarcoma, first discovered incidentally on routine urine analysis, which is one of the first of it’s kind to be reported. We describe the vanishingly rare phenomenon of renal myeloid sarcoma presenting without haematological manifestation while also highlighting the often inevitable transformative nature of the disease. We also describe the unusual immunohistochemistry findings, in particular the cytokeratin expression, that is not usually typical of such cases. We briefly discuss use of PET-CT for the disease response monitoring. We summarize treatment that has included palbociclib, use of which was previously reported only in small series of patients with AML with KMT2A mutation.
format	article
author	Claire Comerford Sarah Ni Mhaolcatha Brian Hayes Vitaliy Mykytiv
author_facet	Claire Comerford Sarah Ni Mhaolcatha Brian Hayes Vitaliy Mykytiv
author_sort	Claire Comerford
title	The first case of acute myeloid leukaemia/myeloid sarcoma with cytokeratin expression on blasts diagnosed on urine specimen
title_short	The first case of acute myeloid leukaemia/myeloid sarcoma with cytokeratin expression on blasts diagnosed on urine specimen
title_full	The first case of acute myeloid leukaemia/myeloid sarcoma with cytokeratin expression on blasts diagnosed on urine specimen
title_fullStr	The first case of acute myeloid leukaemia/myeloid sarcoma with cytokeratin expression on blasts diagnosed on urine specimen
title_full_unstemmed	The first case of acute myeloid leukaemia/myeloid sarcoma with cytokeratin expression on blasts diagnosed on urine specimen
title_sort	first case of acute myeloid leukaemia/myeloid sarcoma with cytokeratin expression on blasts diagnosed on urine specimen
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/ef1254df48044cbf8422afe510b38d0b
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The first case of acute myeloid leukaemia/myeloid sarcoma with cytokeratin expression on blasts diagnosed on urine specimen

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